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Showing papers in "American Journal of Hypertension in 1994"


Journal ArticleDOI
TL;DR: Among life-style habits such as diet, sedentary activity, and cigarette smoking, only the latter has been consistently used in CAD prediction because of its independent effect, and prediction equations continue to emphasize the traditional biological factors and not behaviors.

424 citations


Journal ArticleDOI
TL;DR: The increased amount of UAE in nondipper hypertensive patients suggests the presence of greater renal damage than in dippers, and whether levels of urinary albumin excretion correlate with average diurnal, nocturnal, or 24-h blood pressure better than with office blood pressure.

376 citations


Journal ArticleDOI
TL;DR: Although the increment in systolic pressure associated with exaggerated exercise response was small, this small increment sustained over time could lead to a substantially increased incidence of hypertension and hypertension-related target organ damage.

212 citations


Journal ArticleDOI
TL;DR: The frequency of the ACE deletion allele was greater in African-Americans with hypertension than in those with normal blood pressure, raising the possibility that in some patient subgroups, sequence variation in or near the ACE gene may contribute to the risk for hypertension.

136 citations


Journal ArticleDOI
TL;DR: The results of this study suggest that lower extremity aerobic exercise has an antihypertensive effect on resting systolic and diastolic blood pressure in adults, however, a need exists for more meticulously controlled investigations on this topic.

134 citations


Journal ArticleDOI
TL;DR: Observations suggest that some inconsistencies in the literature regarding the effects of salt restriction on insulin may be explained by baseline anthropometric and metabolic differences in the subjects studied.

129 citations


Journal ArticleDOI
TL;DR: It is indicated that the receptors for adrenomedullin exist in the brain, and that the receptor site may be anatomically far from the surface of the brain and the ventricular system because the onset of the pressor response was delayed.

122 citations


Journal ArticleDOI
TL;DR: The marked decline in blood pressure during daytime sleep suggests that sleep itself, rather than an endogenous circadian rhythm, is responsible for the blood pressure dip observed during both daytime sleep and nighttime sleep.

112 citations


Journal ArticleDOI
TL;DR: It is concluded that ischemic stroke is associated with marked acute and long-duration increases of ET-1 and ANP and there was no correlation between the ANP plasma values and the neurologic status, the site or mechanism of the stroke, or the plasmaET-1 levels.

105 citations


Journal ArticleDOI
TL;DR: An updated meta-analysis of published studies in diabetics with microalbuminuria or clinical proteinuria treated with conventional agents, angiotensin-converting enzyme (ACE) inhibitors, or calcium antagonists (Ca2+ antagonists) presents an updated finding that despite similar blood pressure (BP) reductions, UProt tended to decrease more on ACE inhibitors than on conventional therapy or Ca2+.

104 citations


Journal ArticleDOI
TL;DR: There was a sustained reduction of both systolic and diastolic pressure throughout the day and night, but the greatest reduction occurred in the morning hours, suggesting the timing of the peak effect may depend on the prevailing level of alpha-adrenergic tone, as well as on the pharmacokinetics of the drug.

Journal ArticleDOI
TL;DR: The results indicated that increased PRA could play an important role in the development of hypertension in subjects with central obesity.

Journal ArticleDOI
TL;DR: The data suggest that the smaller diurnal change in blacks may be related in part to their higher blood pressure levels, but that there is an additional, independent effect of race.

Journal ArticleDOI
TL;DR: Stretch activation of large-conductance, Ca(2+)-activated K+ channels in mesenteric artery smooth muscle cells seems to be due to a direct effect of stretch on the channel itself or on some closely associated, membrane-bound entity.

Journal ArticleDOI
TL;DR: The arteriolar wall thickness and left ventricular mass as well as the vascular response to norepinephrine and acetylcholine in spontaneously hypertensive rats (SHR), before and after the development of hypertension, as compared to age-matched normotensive Wistar-Kyoto rats (WKY).

Journal ArticleDOI
TL;DR: Among hypertensive patients with elevated excretion rates of urinary albumin, even at the subclinical level, an increased cardiovascular risk exists compared to normoalbuminuric patients with a similar blood pressure.

Journal ArticleDOI
TL;DR: High-resolution ultrasonic echotracking device was used to measure internal diameter and intima-media thickness of the radial artery in 60 hypertensive patients and in 40 age-matched control subjects, finding significant univariate relations existed between radial artery mass and blood pressure and radial arterymass and age.

Journal ArticleDOI
TL;DR: Cough was spontaneously reported to occur in 8.5% with lisinopril compared to 3.1% with nifedipine, and nonsmokers reported an increase in cough more often than did smokers.

Journal ArticleDOI
TL;DR: It is suggested that in this model increased renin, and presumably AII, does not mediate significant proliferative or phenotypic changes in the kidney in the absence of hypertension at 11 weeks.

Journal ArticleDOI
TL;DR: The view that arterial tree is a target organ for mineralocorticoids and may be of importance in the pathogenetic mechanism of MC-induced hypertension is supported.

Journal ArticleDOI
TL;DR: It is concluded that increased variability in circadian blood pressure per se, as well as hypertension, could induce aortic atherosclerosis in the hypercholesterolemic and endothelium-denuded rats.

Journal ArticleDOI
TL;DR: Coadministration of HCTZ and nifedipine further decreased the mean arterial pressure to 103 +/- 2 mm Hg after 12 months of treatment and plasma levels of creatinine, potassium, uric acid, cholesterol, and norepinephrine remained unchanged.

Journal ArticleDOI
TL;DR: Correlations between insulin resistance, hyperinsulinemia, and hypertension do not appear to be explainable by the concept that insulin resistance occurs secondary to hypertension, and obesity may be a key factor in explaining these relationships.

Journal ArticleDOI
TL;DR: A reduction in mean QKD interval is found with age and hypertension, reflecting the recognized higher pulse wave velocity in patients with stiffer arteries, suggests this recently developed device enables evaluation of the influence of blood pressure on arterial rigidity.

Journal ArticleDOI
TL;DR: It is indicated that concomitant increases in total peripheral resistance appear to account for the greater blood pressure reactivity in African-American girls.

Journal ArticleDOI
TL;DR: The primary objective of this study was to compare the antihypertensive efficacy and safety of intravenously administered nicardipine with that of intravenous nitroprusside (SNP) in patients with severe hypertension.

Journal ArticleDOI
TL;DR: In this paper, the effects of a single daily dose of doxazosin (an alpha-adrenergic blocker) given at night were evaluated in 112 patients with mild hypertension.

Journal ArticleDOI
TL;DR: The data suggest that a stronger association between blood pressure levels and urinary albumin excretion exists in young blacks than in whites, which supports the notion that blacks may be more susceptible to renal damage from relatively low levels of blood pressure increases.

Journal ArticleDOI
TL;DR: This study indicates that the postulated sodium, potassium ATPase inhibitor that circulates in plasma is not ouabain, but it is likely to be structurally similar to ou abain, as it appears to cross-react with some antibodies against ouABain.

Journal ArticleDOI
TL;DR: The high prevalence of associated lesions in the carotid and peripheral circulation in patients with renovascular disease secondary to atherosclerosis should prompt investigation of these major arteries when renal artery disease is detected.