Showing papers in "Asian Journal of Pharmaceutical Sciences in 2018"

TL;DR: A review of relationships between structure, activity, and pharmacokinetics of bioactive flavonoids is presented in this article, which attempts to bring some order into relationship between structure and activity.

TL;DR: CD/CS-SCU-NPs were prepared by ionic cross-linking method and Orthogonal design was used to optimize the formulation.

TL;DR: In this article, the authors review the progress and challenges of RNAi therapy, and discuss the potential of exosomes' applications in small RNA delivery with focus on the most recent advances in exosome-based smallRNA delivery for disease therapy.

TL;DR: The utility of various vesicular nanocarrier systems to treat skin fungal infections is discussed about about bioavailability enhancement of bioactives, high skin permeation power, no side effects at application site, dosing frequency reduction, and sustained drug release.

TL;DR: It can be seen that nano-cocrystal is an appropriate novel strategy for improving dissolution rate and bioavailability of poor soluble natural products such as BE.

TL;DR: In this article, an ionic cross-linking method and film casting technique were used to prepare nanoparticles and muco-adhesive blend films, respectively, to improve the permeability of drugs that undergo first-pass metabolism.

TL;DR: In vitro PR accumulation in full-thickness newborn pig skin demonstrated that the application of elastic carrier formulations gave significantly higher accumulation than liposomes, and gave anti-tyrosinase activity up to 80%.

TL;DR: The skin adherence, translucence, and ventilation properties of the prepared PNPs indicated that they are appropriate for topical application, and the conductivity of the polymer solution increased with increasing PVA and clindamycin concentrations, and increasing the PVA concentration enhanced the solution viscosity.

TL;DR: Graphical Abstract Unlabelled image Combination of Budesonide and Colchicine Dry powder inhaler Liposomes proved to be effective for Idiopathic Pulmonary fibrosis.

TL;DR: The PR8-TMC-ALG formulation could be considered as an efficient intranasal antigen delivery system for nasal vaccines.

TL;DR: It was suggested that the fabrication of stable coconut oil nanoemulsions with small particle size could be easily achieved by using 5% (w/w) PHC as a surfactant.

TL;DR: Results demonstrate that the developed nanoparticles of quaternized cyclodextrin-grafted chitosan associated with HA in different molar ratios of QCD-g-CS and HA are promising for future applications in cosmetics.

TL;DR: The results extended the understanding about the application of cyclodextrin complexation and provided guidance for the design of ODF especially for drugs with disgusting taste.

TL;DR: ATC-P188 solid dispersions would be prospective means for enhancing higher oral bioavailability of ATC and the pharmacokinetics after oral administration of Lipitor and solid dispersion were investigated.

TL;DR: Caffeic acid /β-cyclodextrin (molar ratio = 1/1), the aromatic ring of the caffeic acid molecule appears to be included from the wider to the narrower rim of the ring of βCD.

TL;DR: NMR study disclosed that the interaction between PCO40 with both VCO and SMO should be a possible stabilization mechanism and revealed the good feasibility of SMO-VCO nanoemulsions as novel carriers for treating of oral cancer.

TL;DR: The addition of cyclopentasiloxane can improve the physical, thermal properties and stability of SMS–sesame oil oleogel, provide greater sensory profile and better product aesthetics, and can be a novel carrier for topical drug delivery.

TL;DR: Wang et al. as discussed by the authors used deep neural network with the improved dataset selection algorithm to predict oral disintegrating tablets (ODTs) on small data, and achieved an accuracy of 85.60%, 80.00% and 75.00%.

TL;DR: Carboxymethylated gum from T. indica and C. fistula seeds is an excellent, naturally sourced gum with high physicochemical and functional qualities, and can potentially be used in pharmaceutical applications as a disintegrant, diluent, and drug release-controlling agent.

TL;DR: Wang et al. as discussed by the authors encapsulated TMP into poly (lactic-co-glycolic acid) (PLGA) microspheres to enhance the TMP retention in the joint, reducing injection frequencies and decreasing dosage.

TL;DR: Poly (lactic-co-glycolic acid) (PLGA)-based microspheres formulation of Bisdemethoxycurcum (BDMC) was prepared by emulsion-solvent evaporation method and the pharmacokinetics and tissue distribution in rats were conducted to evaluate BDMC-PLGA-MS preliminarily.

TL;DR: In this article, a mathematical model that describes progesterone controlled release from poly-3-hydroxybutyric acid (PHB) membranes was proposed and a statistical analysis was conducted to compare the fitting of the model with six different models and the Akaike information criterion (AIC) was used to find the equation with best fit.

TL;DR: In this paper, a DEM model is used to predict agglomeration as a function of impeller speed and liquid addition rate in a high shear wet granulator, which can be applied under dynamic process conditions with high predictive capacity to improve process insight.

TL;DR: It can be concluded that appropriately surface-modified MSNs can be considered as prospective vectors for therapeutic siRNA delivery by modifying the pore walls of MSNs with surface-hyperbranching polymerized poly(ethyleneimine) (hbPEI).

TL;DR: It was found that the Carbopol Ultrez 21-based hydroalcoholic gel containing an aqueous extract of coconut kernels exhibited antioxidant activities in the two assays and showed a sufficient consistency, a pleasing color, and a non-oily perception during the period of observation.

TL;DR: Both solution and precipitate characteristic properties will be useful for using β-CyD in further investigation as matrix material dissolved in the injectable vehicles as the in situ forming gel for periodontitis treatment.

TL;DR: CS–CBM matrix tablets are promising system to tune and control the release of highly water-soluble drugs with good system robustness and simple preparation process.

TL;DR: It is addressed in this work that F127-modified SNEs have potentials to improve oral drug absorption by significantly reducing gastrointestinal enzymatic degradation and simultaneously enhancing mucus penetration.

TL;DR: The DTX-MM-hydrogels prepared in this study have considerable potential as a drug delivery system, with higher tumor inhibition effects and are less toxic to normal tissues.

TL;DR: The present study corroborated the idea that the PEPT1-mediated prodrug approach has enormous promise for improving the oral absorption of poorly absorbed drug and suggested Peramivir-(CH2)2-l-Val with good oral profiles and rapid bioactivation might be a promising prodrug for the further clinic development.