Showing papers in "Atherosclerosis in 1978"

TL;DR: There was no evidence that former cigarette smokers, with the exception of those who switched to cigars or pipes or had quit less than one year, had lower HDL levels, and cigar or pipe smokers who had never smoked cigarettes had alcohol- and skinfold-adjusted HDL cholesterol comparable to the non-smoker.

TL;DR: It is proposed that HDL 2b and HDL 2a levels may be the critical HDL components determining the reported inverse correlation of HDL cholesterol with coronary heart disease.

TL;DR: It is suggested that the first stage of experimental atherosclerosis may be causally related to the strong suppression of PGI 2 generation by arteries, whereas the metabolism of AA in platelets remains unchanged.

TL;DR: The results suggest that the activity of LPL in adipose tissue and the rate of catabolism of triglyceride-rich lipoproteins might be one of the factors that determine the concentration of HDL in plasma and at least partly account for the known sex difference in plasma HDL level.

TL;DR: In this article, the effect of essential oil of garlic on platelet aggregation was studied in vitro with an aggreganometer and the results showed that adding essential oil to garlic extract inhibited in-vitro aggregation induced by ADP, epinephrine or collagen; the effect was dose-related.

TL;DR: The association of copper with cardiovascular disease and a possible involvement of copper in the metabolism of cholesterol prompted the study on hypercholesterolemia mediated by copper deficiency, and the results are discussed in terms of a possible role for copper in cholesterol metabolism, and in the pathogenesis of atherosclerosis.

TL;DR: The data indicate that diabetes may be associated with shifts in distribution of LDL and HDL, as well as with increases in VLDL.

TL;DR: In the fasting state the lipoprotein-lipase activity of skeletal muscle was inversely related to the ratio between the concentrations of insulin and glucagon.

TL;DR: A high negative correlation existing both in females and males between values of index body weight (IBW) and plasma levels of HDL cholesterol and apo A1 is stressed.

TL;DR: A decrease in cholesterolemia and plasma phospholipid levels, normalization in the distribution of plasma lipoproteins, and reduction in the extent of aortic and coronary atherosclerosis were observed in monkeys fed the semipurified diet containing alfalfa, although the intake of cholesterol remained as high as in the usual American diet.

TL;DR: The response of the plasma cholesterol levels to plasmapheresis was subjected to kinetic analysis based on a current model of the regulation of lipoprotein metabolism to establish a new approximate "steady state" with a serum cholesterol concentration of 176--199 mg/100 ml.

TL;DR: The observations suggest a more rapid synthesis and clearance of cholesterol to the plasma pool, with this cholesterol being unavailable for excretion as biliary steroids, in copper-deficient rats.

TL;DR: The sieving of chylomicrons, remnants and other lipoproteins by the sinusoidal endothelium of the liver may play an important role in lipid transport, affecting the balance of various lipoprotein moieties which in turn may affect the relationship of dietary lipids to various hyperlipidaemias and atherosclerosis.

TL;DR: Evidence is given that these drugs can affect both, the rate of synthesis and the substrate affinity of hydroxymethylglutaryl CoA reductase and that they diminish the activity of this enzyme in rat liver microsomes.

TL;DR: The transfer represented an equilibration of molecules, but no net mass transfer of cholesterol esters could be demonstrated from HDL to LDL, and this transfer was reversible, time-dependent and a function of the concentration of the d greater than 1.25 fraction, but independent of lecithin : cholesterol acyltransferase reaction.

TL;DR: A high proportion of positivity was recorded in myocardial infarction and in arteriosclerosis obliterans and the possible pathogenic role of the circulating immune complexes is discussed.

TL;DR: It is concluded that the in vivo degradation rate of HDL-apoproteins is not influenced by the removal of 2/3 of the liver and that the decrease in serum HDL concentration is due to an impaired rate of hepatic synthesis.

TL;DR: The results suggest that HS would be a more effective hypocholesterolemic agent than S, and the ratio of sterol in very low density lipoprotein to that in high density cholesterol was less for HS or S than for endogenous cholesterol; this was particularly marked with HS.

TL;DR: It is suggested that the protective effect of prophylactic treatment with clofibrate against isoproterenol-induced myocardial infarction in rats may be due to its ability to change corticosterone levels in the circulation.

TL;DR: Cholesterol was increased in mild, and even further in advanced, atheroslcerosis, and the concentrations of chondroitin sulphates and glycoprotein-bound hexosamines were not significantly affected by atherosclerosis.

TL;DR: Results indicate that platelets may be activated in apparently normal people consuming a SF diet and that this activation may be decreased by replacement of dietary SF with PUF.

TL;DR: It is suggested that the hypercholesterolaemia may affect the regeneration of arterial endothelial cells in young male New Zealand White rabbits.

TL;DR: In rats, estrogen-induced hypolipidemia is associated with a nearly complete absence of the lipid and protein moieties normally found in d less than 1.21 fraction of serum.

TL;DR: Glycosaminoglycan-lipoprotein complexes were isolated from rabbit aortas exhibiting nearly confluent cholesterol-induced foam cell lesions by extraction with 0.15 M NaCl.

TL;DR: Results show that the active constituent(s) in garlic responsible for its anti-atherogenic action is present in the oily fraction of garlic.

TL;DR: Bezafibrate is a well-tolerated drug with a good VLDL TG lowering effect and is particularly effective in increasing HDL cholesterol concentrations.

TL;DR: Three new diphosphonic acids, i.e. compounds containing a P-C-P bond, have been investigated for their ability to inhibit the vitamin D-induced calcification of aortas and kidneys in rats and markedly decreased the amount of calcium deposited in aorta and kidneys.

TL;DR: Observations suggest that platelet sequestration in the myocardial vasculature may be related to the presence of disease in the coronary arteries.

TL;DR: The clinical and necropsy findings indicated that PHB was an effective antiatherosclerotic agent which reduced the extent and severity of the disease and protected against obstructive atherosclerosis disease of the coronary and peripheral arteries.