Showing papers in "Chemico-Biological Interactions in 1969"

TL;DR: The binding values of AAF to ribosomal RNA probably are a reflection of sulphotransferase activities in vivo livers to the carcinogenic action of N -hydroxy-AAF and AAF.

TL;DR: The results support the hypothesis that in contrast to phenobarbital, 3,4-benzpyrene yields a modified cytochrome (P-448) in the liver microsomes with an increased affinity for 3, 4-benZpyrene as well as a decreased affinity for aminopyrine.

TL;DR: Red blood cell “ghosts” (plasma membranes) differed from other tissues in that its Na+-K+ ATPase activity was insensitive to the insecticides, except for a slight effect from Kelthane.

TL;DR: An extended series of substituted 1-phenylaziridines has been prepared and the activity as inhibitors of the transplanted Walker carcinoma 256 has been examined as discussed by the authors, where the presence of an effective alkylating centre in the molecule is essential for tumour-growth inhibitory activity.

TL;DR: The interaction of N-hydroxy-FAA with the soluble proteins in vitro gave highly labeled adducts which lacked the acetyl group of the hydroxamic acid, which contributed also to adduct formation in vivo.

TL;DR: Two soluble liver proteins in the rat have a high affinity of binding for metabolites of azodye carcinogens and their binding is to methionyl residues, since methionine is an essential amino acid, in the basicAzodye-binding protein azODYe metabolites bind to cysteinyl residues and in the small molecular weight azodyE-bindingprotein, binding isto methiony residues.

TL;DR: The data presented are consistent with the hypothesis that the glucuionide of N -Hydroxy-2-acetylaminofluorene accounts for most of the binding of the carcinogen N -hydroxy-3 H-acetyl- N -2-fluorenylhydroxylamine to rat-liver DNA in vivo.

TL;DR: It is suggested that MMS-induced damage can be repaired but in order for cell recovery to accompany this repair, the synthesis of new DNA must be delayed until after the repair process is complete.

TL;DR: Replicating and non-replicating DNA were isolated in an isopycnic density gradient from cultured fetal mouse skin cells after incubation with 5-bromodeoxyuridine and 7,12-Dimethylbenz(a)anthracene binding was reproducibly greater to the non- replicating DNA.

TL;DR: The possibility that an observable alteration in DNA may play a role in carcinogenesis is indicated and a possible mechanism for the progressive nature of the cellular changes during cancer induction is suggested.

TL;DR: Only with respect to nuclear DNA was there a relationship between depressed binding of isotope from n -hydroxy- n -2-fluorenylacetamide after prefeeding select agents and the inhibitory effect of these agents on tumor induction in the liver of rats.

TL;DR: It is discussed that the increased susceptibility of ESNS-treated bladders to chemical carcinogens is due to damage to the luminal barrier membrane, which thus permits access of the carcinogens to the tissue at a time when the mitotic index is raised.

TL;DR: In aqueous solution, single-stranded DNA was more susceptible to the photosensitizing action of 4-nitroquinoline 1-oxide than the double- Stranded DNA, indicating that intercalation of the quinoline compound between the base pairs in DNA is not necessary for the photosensing action to DNA.

TL;DR: The early appearance of nucleoli in embryos, after treatment with cycloheximide, might result from a failure to elaborate a factor which in normal embryos would inhibit ribosomal RNA synthesis.

TL;DR: It is concluded that inactivation of the acceptor site is the basis for the inhibition of tRNA function by HN2.

TL;DR: In this paper, the authors studied the influence of the nature and extent of the chemical modifications on the inhibition of the multiplication of an Arbovirus (virus Sindbis) on fibroblasts of chicken embryos.

TL;DR: The failure to eliminate the enzyme from the mitochondria and the absence of effect when supernatant was added to mitochondria oxidizing ethanol strongly indicate that the ethanol oxidation studied is a true mitochondrial process and is not caused by contamination from thesupernatant.

TL;DR: The results, together with those previously reported, indicate that the native polar dye can be classified into two groups: one, P 2b is methionine-derived and the other, p 2a, is tyrosine- derived and both can be converted to sub-components of P 3.