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Showing papers in "Clinica Chimica Acta in 1963"


Journal ArticleDOI
TL;DR: The preparation of a standard curve, the reproducibility of results and arguments for expressing in clinical practice the fibrinogen content in terms of whole blood rather than plasma are discussed.

265 citations


Journal ArticleDOI
TL;DR: If phenazone is substituted for perchloric acid or arsenic pentoxide in the diacetylmonoxime reaction for urea determination, a colored product is formed, apparently from a double condensation of Phenazone with diacetymoxime and urea, and Beer's law is followed.

134 citations


Journal ArticleDOI
TL;DR: It is shown that lactic dehydrogenase activity in homogenates is much higher if the isoenzymes are separated prior to assay, and Enzyme determinations inhomogenates may give results which correspond to less than half the true enzyme activities.

75 citations


Journal ArticleDOI
TL;DR: The results obtained indicate that amylase exists in serum as an unbound moiety, and that the amylases from human serum, saliva, pancreatic juice, urine and extract of pig pancreas all have an electrophoretic mobility similar to γ-globulin.

70 citations


Journal ArticleDOI
TL;DR: The plasma glycerol was found to be increased in 2 of the patients with glycogenosis as compared with normal subjects and a healthy brother, and increased tissue lipolysis is considered to be a possible, although not at all the only possible, explanation.

66 citations


Journal ArticleDOI
TL;DR: In this paper, a method for the determination of ammonium in blood and tissue extracts is described, where no complicated apparatus is needed for this timesaving procedure and micro-diffusion as a source of errors can be avoided.

62 citations


Journal ArticleDOI
TL;DR: The proteinuria accompanying non-specific renal tubular dysfunction has been shown to differ from that associated with glomerular dysfunction both by sedimentation velocity and electrophoretic criteria.

59 citations


Journal ArticleDOI
TL;DR: The method used presents a routine technique which may be useful in differential diagnosis between bone and liver disease and three main bands of enzyme activity are found, two of which are related to the river whereas the third one is proved to be of bone origin.

57 citations


Journal ArticleDOI
TL;DR: Children, two years or more of age, have the same arylesterase activity as normal adults, and there is a steady increase in this activity during the first six months after birth, when the activity is significantly lower than in two-year old children.

51 citations


Journal ArticleDOI
TL;DR: The data presented are difficult to reconcile with the hypothesis that the excretion of abnormal quantities of tryptophan metabolites, suggested as endogenous carcinogens, might have caused the induction of cancer only when excreted by bladder tumour patients.

47 citations



Journal ArticleDOI
TL;DR: No correlation was found between urine flow and the excretion of calcium or magnesium during water diuresis but there was a significant correlation between urine Flow and theexcretion of sodium and potassium.

Journal ArticleDOI
TL;DR: The LDH isozyme distribution is virtually unchanged when LDH passes from the blood into the CSF, and changes in serum LDH patterns are not accompanied by changes in CSF LDH isozymes.


Journal ArticleDOI
TL;DR: The method is quicker and more sensitive than column and paper chromatography and the results are in good agreement with these other methods.

Journal ArticleDOI
TL;DR: Evidence is presented to support the view that normal plasma contains free serotonin, quantitatively determined in samples from normal subjects and hospital patients using a spectre photofluorimetric method.

Journal ArticleDOI
TL;DR: Determinations of ionised calcium in normal and pathological sera by the direct method are in good agreement with the results obtained by Rose's method, and the ratio of ionic to total calcium was found to be independent of total calcium concentration.

Journal ArticleDOI
TL;DR: Serum proteins of the human, cat, rabbit, monkey and rat were separated by starch gel electrophoresis and in addition to protein, cholinesterase, esterase and proteolytic activities were determined.

Journal ArticleDOI
TL;DR: One of the Cerebrospinal fluid proteins studied was studied in more detail and proved to have an electrophoretic mobility essentially dependent upon the conditions of storage of the C.S.F. samples.

Journal ArticleDOI
TL;DR: The method permits kinetic measurements and is also applicable to the assay of trypsin in pancreatic juice, and is easy, rapid and two hundred fold more sensitive than any other reported method.

Journal ArticleDOI
TL;DR: In 35 of a group of 59 patients suffering from depressions of varying origin, the glucose tolerance test was disturbed by the period of hyperglycaemia being prolonged (increased HI), and a statistically significant correlation was found between the occurrence of serious manifestations of psychological tension and the occurrences of disturbances in glucose tolerance.


Journal ArticleDOI
TL;DR: The results support the conception that the main reason for the high faecal stearic-oleic acid ratio compared with that in the diet is due to the preferential absorption of oleic acid.

Journal ArticleDOI
TL;DR: Serum of normal persons and especially of pregnant women splits l -leucine-β-naphthylamide (LN) better than L-leucinamide (LA) and a correlation between the splitting of LN and the LAP activity cannot be established without limitation.

Journal ArticleDOI
TL;DR: Immunoelectrophoresis with anti-gastric juice antiserum (preferably the autoradio-graphie procedure) can be used as a laboratory test to demonstrate the presence or absence of intrinsic factor in gastric juice specimens.

Journal ArticleDOI
TL;DR: Storage of concentrated human CSF at −10° for about one week leads to a shift in the electrophoretic mobility of part of the γ -tr protein towards the anode, which results in a double arc appearance in immunoelectrophoresis.


Journal ArticleDOI
TL;DR: Quantitative analysis of the phospholipid content of pooled CSF and specimens of CSF from some neurological disorders has been investigated by thin layer chromatography and optimum conditions for maximum development of molybdenum blue found to be within closer limits of time and normality than previously reported.

Journal ArticleDOI
TL;DR: In this article, a method for automatic analysis of aldohexoses and, more particularly, of glucose in body fluids is proposed, which is done with the Technicon autoanalyzer and o -toluidine in acetic acid reagent.

Journal ArticleDOI
TL;DR: Leucocyte extracts from 11 normals, from a patient with lymphatic leukemia and from 5 patients with myeloid leukemia were investigated for their content of acid mucopolysaccharides; in 9 of the normal and in 3 cases of myeloids leukemia findings were identical.