Showing papers in "Clinica Chimica Acta in 2021"

TL;DR: In this article, the authors measured SARS-CoV-2 Antibodies (Ab) using chemiluminescent assays against the spike (S) protein and the Receptor Binding Domain (RBD) of the virus, respectively.

TL;DR: MicroRNAs are a class of endogenous noncoding single-stranded RNA molecules with approximately 20-24 nucleotides and are associated with a broad range of biological processes.

TL;DR: A brief review of the dopamine synthetic pathway, binding to the dopamine receptors, and subsequent action is presented in this paper, where four different pathways and functions of the dopaminergic system are presented in this review.

TL;DR: In this article, the authors compared salivary and naso-pharyngeal swab (NPS) SARS-CoV-2 antigen detection by a rapid chemiluminescent assay (CLEIA) and two different point-of-care (POC) immunochromatographic assays, with results of molecular testing.

TL;DR: The circRNA-miRNA-mRNA axis may be a marker for the early diagnosis and prognosis of breast cancer and a potential breast cancer treatment target, providing unlimited possibilities for the development of biomarkers and therapeutic strategies as discussed by the authors.

TL;DR: In this article, the authors developed and validated the PrecivityAD test for clinical Alzheimer's disease (AD) diagnosis, which is an accessible, less invasive, cost-effective method to facilitate clinical trial enrollment and aid in clinical AD diagnosis.

TL;DR: High-performance liquid chromatography with quadrupole time-of-flight mass spectrometry revealed that 29 GPs were identified and relatively quantified as differential metabolites for discriminating asthma patients and healthy subjects, consisting of six major subclasses of GPs.

TL;DR: In this article, the vital role of mitochondrial iron in pathologic states including neurodegenerative disorders and sideroblastic anemia was highlighted. But, the authors did not discuss mechanisms of iron metabolism including transport, processing, heme synthesis, iron-sulfur cluster biogenesis and storage.

TL;DR: In this paper, the authors summarized the major literature with regard to the application of ddPCR in detecting the pathogenic microorganisms of infectious diseases, including bacteria, fungi, and virus.

TL;DR: Wang et al. as discussed by the authors investigated the dynamic changes in lipid profiles and their correlations with disease severity and clinical outcome in patients with severe COVID-19 patients with confirmed outcomes (discharged or deceased), admitted to the West Court of Union Hospital in Wuhan, China, between 29 January and 8 April 2020.

TL;DR: This review aims to briefly introduce the potential application of exhaled breath analysis for the diagnosis and screening of various diseases, thereby providing a new avenue for the detection of non-invasive diseases.

TL;DR: Recent evidence about the pro- atherosclerotic effects of resistin is gathered and it is highlighted as a candidate therapeutic or diagnostic target for cardiovascular disease.

TL;DR: In this paper, the authors compared two serological assays from Roche Diagnostics in individuals with and without COVID-19 vaccination, namely the Elecsys Anti-SARS-CoV-2 assay (detecting antibodies against the nucleocapsid protein of SARS CoV2) and the Elemsys Anti SARS-coV2 S assay, and found that 62.9% of all determinations were negative with both Roche assays and 31.5% were positive with both assays.

TL;DR: In this article, the authors present the position of this IFCC Committee on Bone Metabolism on the latest developments concerning the measurement and standardization of vitamin D metabolites and its binding protein, as well as clinical indications for their measurement and interpretation.

TL;DR: In this article, the Working Group on Continuous Glucose Monitoring aims at establishing a traceability chain for minimally invasive continuous glucose monitoring (CGM) systems, as well as procedures and metrics for the assessment of their analytical performance.

TL;DR: In this article, the frequency of ACE I/I homozygotes was significantly increased in COVID-19 patients compared with that in controls (26.2% vs. 21.2%; P = 0.002; OR [95% CI] = 1.78 [1.22-2.60]).

TL;DR: A reproducible and highly concentrated WS, specific for IgG against SARS-CoV-2 Spike-glycoprotein was produced, which is particularly suited for the harmonization of commercially available assays and the consequent evaluation of post-vaccinated individuals.

TL;DR: It is found that patients diagnosed with chronic pain, as in RA, and those refractory to contemporary management are most likely to seek traditional medicine.

TL;DR: In this article, the ability of SARS-CoV-2 mRNA vaccines to induce at least a 4 months-lasting IgG response, even outside the rules of clinical trials, was investigated.

TL;DR: In this article, the authors proposed a method to identify SARS-CoV-2 nucleic acid in the first week of infection, which is associated with high viral loads.

TL;DR: The IFCC Committee on Bone Metabolism has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma to help develop universally acceptable practice guidelines for the management of osteoporosis.

TL;DR: In this paper, the authors evaluated global VOCs and their discrimination capacity in chronic obstructive pulmonary disease (COPD), lung cancer, breast cancer and healthy subjects by chemoresistive sensors and chemometric analysis.

TL;DR: In this paper, the concentrations of serum KL-6 and fibronectin at hospital admission were tested using the method of latex agglutination assay and immunoturbidimetic assay, respectively.

TL;DR: In this paper, the role and mechanism of action of ABCA1 in efferocytosis and its potential as a novel therapeutic target in atherosclerosis were reviewed, focusing on new insights into the ABCA 1-effeurectosis axis.

TL;DR: The role of miRNAs in the pathogenesis of multiple sclerosis (MS) was discussed in this article, where the authors highlighted the potential of microRNAs as biomarkers of MS and potential therapeutic agents.

TL;DR: Histocompatibility leukocyte antigen complex P5, initially reported in 1993, is an important lncRNA located between the MICA and MICB genes in MHC I region and represents a promising biomarker and therapeutic target in cancer.

TL;DR: In this paper, a literature survey of analytical and calculation-based methods for low-density lipoprotein (LDL) determination in plasma, present their principles, strengths and weaknesses, and examine the challenges arising from method comparison.

TL;DR: In this paper, a review of potentiometric urea biosensors reported in the literature and touched upon their certain structure characteristics and performance parameters including detection limit, working concentration range, response time and lifetime.

TL;DR: A structured overview is offered that focusses on the core proteins of the circadian clock and their interactions with inflammatory players, and provides a potential mechanism for the pathological rhythms observed under inflammatory conditions.

TL;DR: HE4, alone or associated with CA125, appears to be an important tool in the management of endometrial cancer, initially for diagnosis, but for assessing prognosis and survival.