Showing papers in "Clinics in Dermatology in 2018"

TL;DR: The metabolic syndrome-otherwise called syndrome X, insulin resistance syndrome, Reaven syndrome, and "the deadly quartet"-is the name given to the aggregate of clinical conditions comprising central and abdominal obesity, systemic hypertension, insulin Resistance, and atherogenic dyslipidemia.

TL;DR: Systemic conventional treatments should be used with caution in psoriatic patients with MetS, because they could adversely affect the coexisting metabolic disorders, especially in the case of their chronic use.

TL;DR: Children and adults with atopic dermatitis are particularly vulnerable to exogenous insults from the outside environment, including climate, ultraviolet exposure, pollution, irritants and pruritogens, and microbes.

TL;DR: Increased mTORC1 activity has been detected in lesional skin and sebaceous glands of acne patients compared with acne-free controls, and is a characteristic feature of insulin resistance, obesity, type 2 diabetes mellitus, cancer, and neurodegenerative diseases.

TL;DR: Advances in diagnosis and treatment of morphea are summarized, allowing clinicians to better serve patients with this condition.

TL;DR: This work has reviewed the literature on balneotherapy in the treatment of skin diseases, as well as describing their use in three different treatment sites, each with unique climates and chemical properties of the mineral water used in balne therapy.

TL;DR: Clinicians' gestalt global assessment of severity, Patient-Oriented Eczema Measure, and intensity of itch may be feasible for clinical practice.

TL;DR: The treatment of DM is a difficult task due to its rarity, its multiple phenotypes, and the fact that the disease may affect multiple organs and is commonly treatment-refractory.

TL;DR: It is concluded that plants play an important role as ethnomedicine in daily life and especially in the health care of the people living in the study area.

TL;DR: With the rising popularity of holistic and natural consumerism, prebiotics, probiotics, symbiotic, and other therapies are under study to find alternative treatments to skin disorders through manipulation or supplementation of the microbiome.

TL;DR: This preliminary study on ethnobotanical dermatology practices indicates that Eastern European traditional medical knowledge represents an important heritage that is currently underexploited.

TL;DR: The link between MetS and hidradenitis suppurativa and its components has been consistently identified in controlled studies and its practical implications are discussed, mainly highlighting the importance of prevention and routine screening for early diagnosis to prevent cardiovascular-related morbidity.

TL;DR: The cutaneous comorbidities of atopic dermatitis and their relationship via their occurrence in conjunction with atopic Dermatitis are discussed.

TL;DR: Recommendations are provided for the assessment and treatment of trichotillomania and excoriation disorder (hair pulling disorder, or HPD), two body-focused repetitive behavior (BFRB) disorders, based on their severity, comorbidities, and behavioral style.

TL;DR: Although there is evidence to support specific treatments for Raynaud's phenomenon, digital ulcers, and cutaneous sclerosis, there are limited rigorous studies evaluating the treatment of other cutaneous signs and clinical manifestations.

TL;DR: Evidence indicates that AN is a useful clinical marker to identify patients susceptible to insulin resistance, the MetS, and type 2 diabetes, andTherapeutic options are limited, and results are unsatisfactory, but Retinoids seem to be the most effective topical treatment, and insulin sensitizers are promising, but controlled studies are lacking.

TL;DR: These guidelines join a series of similar efforts published recently across the world, reflecting universal interest in distilling the tremendous volume of basic scientific and clinical data previously generated.

TL;DR: The current understanding and research behind traditional therapies prevalent in the Indian subcontinent are reviewed, including mind-body and energy-based healing, botanical medicine, and herbal remedies.

TL;DR: The metabolic syndrome (MetS) or insulin resistance syndrome is a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease, associated with ectopic lipid deposit and mitochondrial dysfunction in skeletal muscle and the liver.

TL;DR: There is evidence to suggest that initial combination therapy with SCS and methotrexate (MTX) may be most beneficial, and patients who fail to improve withSCS alone require the addition of a second immunosuppressive drug.

TL;DR: The paper will report some general data to support the use of chitin and lignin as natural biomaterials for tissue engineering in regenerative medicine.

TL;DR: This work has reviewed studies concerning the relationship between alopecia and MetS and its individual components, particularly in men, where a disproportionately large number of these studies supports this association.

TL;DR: Preliminary evidence, biological activity studies, and small pilot clinical trials conducted outside of North America suggest that someplementary and alternative medicine approaches may have value in acne treatment.

TL;DR: Validated PRO and QOL measures should be incorporated in all clinical trials of AD and in clinical practice where feasible, and their properties, strengths, weaknesses, and feasibility for assessing AD in randomized controlled trials and clinical practice are addressed.

TL;DR: Initial studies on the efficacy of psychotherapeutic approaches to different problems, such as scratching, comorbidity, or stress-associated itch, show that these might be very useful additions to the multidisciplinary treatment of pruritus.

TL;DR: Newer evidence suggests the possibility that treatment of the skin with commensal bacterial species could also reduce S. aureus growth and increase diversity.

TL;DR: A number of botanicals that are used across Africa and the phytochemical actives that are responsible for skincare are examined to protect, enhance, and preserve the skin in its healthiest state to maintain its barrier function, thus protecting the human body.

TL;DR: The cutaneous manifestations of obesity and the associated metabolic syndrome (MetS) may present with a wide variety of cutaneous findings, including acanthosis nigricans, acrochordon, cellulitis, psoriasis, hidradenitis suppurativa, acne, and hirsutism, and being aware of such clinical signs and the underlying systemic disorders may facilitate earlier diagnoses.

TL;DR: The traditional armamentarium of therapies used for RP, as well as newer medical and surgical options, are summarized with particular regard to the clinical evidence for their efficacy.

TL;DR: Women, young patients, and those with significant AA or previous psychiatric disorders are at greater risk, requiring careful monitoring and proper awareness and consciousness about the close relationship between AA and psychologic factors are essential.