T
Thomas Wurdinger
Researcher at VU University Medical Center
Publications - 184
Citations - 16228
Thomas Wurdinger is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Cancer & Glioma. The author has an hindex of 49, co-authored 170 publications receiving 13289 citations. Previous affiliations of Thomas Wurdinger include VU University Amsterdam & University of Amsterdam.
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Journal ArticleDOI
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Matthias Nahrendorf,Filip K. Swirski,Elena Aikawa,Lars Stangenberg,Thomas Wurdinger,Jose-Luiz Figueiredo,Peter Libby,Peter Libby,Ralph Weissleder,Mikael J. Pittet +9 more
TL;DR: This work identifies two distinct phases of monocyte participation after MI and proposes a model that reconciles the divergent properties of these cells in healing and identifies new therapeutic targets that can influence healing and ventricular remodeling after MI.
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Functional delivery of viral miRNAs via exosomes
D. Michiel Pegtel,Katherine Cosmopoulos,David A. Thorley-Lawson,Monique A. J. van Eijndhoven,Erik S. Hopmans,Jelle J. Lindenberg,Tanja D. de Gruijl,Thomas Wurdinger,Jaap M. Middeldorp +8 more
TL;DR: These findings are consistent with miRNA-mediated gene silencing as a potential mechanism of intercellular communication between cells of the immune system that may be exploited by the persistent human γ-herpesvirus EBV.
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MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
Galina Gabriely,Thomas Wurdinger,Santosh Kesari,Christine Esau,Julja Burchard,Peter S. Linsley,Anna M. Krichevsky +6 more
TL;DR: It is demonstrated that miR-21 regulates multiple genes associated with glioma cell apoptosis, migration, and invasiveness, including the RECK and TIMP3 genes, which are suppressors of malignancy and inhibitors of matrix metalloproteinases (MMPs).
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In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior
Anoek Zomer,Carrie Maynard,Frederik J. Verweij,Alwin Kamermans,Ronny Schäfer,Evelyne Beerling,Raymond M. Schiffelers,Elzo de Wit,Jordi Berenguer,Saskia I.J. Ellenbroek,Thomas Wurdinger,Thomas Wurdinger,D.M. Pegtel,Jacco van Rheenen +13 more
TL;DR: It is shown that EVs released by malignant tumor cells are taken up by less malignant tumors cells located within the same and within distant tumors and that these EVs carry mRNAs involved in migration and metastasis.
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Overcoming the blood-brain tumor barrier for effective glioblastoma treatment
O. van Tellingen,B. Yetkin-Arik,M.C. de Gooijer,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger,H.E. de Vries +7 more
TL;DR: Methods to overcome the blood-brain tumor barrier barrier (BBTB) are provided, including osmotic blood- brain barrier disruption (BBBD), bradykinin receptor-mediated BBTB opening, inhibition of multidrug efflux transporters, receptor- mediated transport systems and physiological circumvention of the BBTB.