Showing papers in "Experimental and Molecular Pathology in 1972"

TL;DR: It was concluded that the paraquat-induced pulmonary fibrosis in humans could be duplicated in monkeys and rats.

TL;DR: The tunica intima of aortas of female rats ranging in age from 0 to 36 months were examined in the electron microscope, revealing an endothelium containing large amounts of ergastoplasm and golgi in both very young and very old rats.

TL;DR: A small dose of carbon tetrachloride, equal to 1 20 of an ld 95, administered intragastrically to rats, confers a remarkable protection against subsequently administered and ordinarily lethal doses of the same liver poison.

TL;DR: While lead acetate induces endotoxin hyperreactivity by impairing the phagocytic as well as the endotoxin-detoxifying properties of macrophages, hepatic parenchymal cell dysfunction may also be a contributing factor.

TL;DR: The major alterations in lipid concentrations consisted of increases in total aorta cholesterol with a marked increase in cholesteryl esters which, in some pooled samples, exceeded the concentration of unesterified cholesterol.

TL;DR: In the branches of the cerebral arteries of hypertensive rats, medial damage preceded intimal fibrinoid degeneration and formation of dense granular, vesicular, and tubular cell debris in the necrotic areas was observed.

TL;DR: Individual variation was seen and proved to be related to gland size, the higher the glands from chronic bronchitis, bronchiectasis, and cystic fibrosisThe relation between gland/wall ratio and secretory tubule and cell size has been estabilished.

TL;DR: There was no evidence of storage of HMR, in contrast to C16 which produced extensive reticuloendothelial retention of material that was still present in Kupffer cells 6 months after administration of C16 was stopped.

TL;DR: The evidence suggests that ACTH controls the process of growth and division of the mitochondria in rat adrenal cortex, which is associated with fusion of existing mitochondria to form giant mitochondria.

TL;DR: In this article, human liver fragments obtained by needle biopsy or surgically were cultured in plastic flasks, using Eagle's medium, human serum, and 95% O 2 -5% CO 2 gas mixture.

TL;DR: Variation in response of infant and older monkeys is attributed to the difference in the hepatic microsomal enzyme activity and the metabolites produced from the biotransformation of monocrotaline.

TL;DR: It is suggested that the Atlantc salmon with its exposure to varying environmental conditions may be a useful model to study the epidemiology of coronary artery disease.

TL;DR: Development and restitution of squamous metaplasia in the glandular portion of the calf prostate was studied with the electron microscope at 4 days and 12 weeks following a single intramuscular injection of either of the synthetic estrogenic compounds diethylstilbestrol or hexestrol.

TL;DR: Injuries induced by galactosamine, found in the animals receiving galactoamine alone and with choline chloride, were autophagic vacuoles, fatty infiltration, liposomes, hypertrophy of the smooth endoplasmic reticulum, reduction of the rough endoplASM, and glycogen depletion.

TL;DR: An electron microscopic study of Coxsackievirus B3-infected newborn mice revealed pathological changes in both the endocrine and exocrine portions of the pancreas.

TL;DR: The findings indicate that feeding a choline-deficient diet to rats can result in alterations of structural lipoproteins, such as those of the microsomal membranes of hepatocytes, as well as of solublelipoprotein such as the VLDL of plasma, which results in a fatty liver.

TL;DR: The carnivorous birds exhibited a high incidence of arterial disease with extensive lipid deposition, in marked contrast to the lipid-poor lesions characteristic of the carnivorous mammals, who were previously thought to have species-resistance to atherosclerosis in spite of elevated serum cholesterol levels.

TL;DR: Results suggest that inherent factors in White Carneau aorta cells are responsible for lipid accumulation under conditions of physiological stress.

TL;DR: Ruthenium red reactivity at these sites was significantly increased in pathological conditions and the periodic bands d − a 4 were the site of interconnection with the network of the connected tissue matrix.

TL;DR: In this paper, the authors evaluated the liver pool size and elimination rate of two poisons: ethylene dibromide (EDB) and carbon tetrachloride (CTC).

TL;DR: Acute lead administration, at a level which does not induce overt lead intoxication or mortality, clearly induces significant pathology in both hepatic cell types, accent a new dimension of the biological effects of lead, namely its ability to induce significant liver parenchymal and macrophage cell alterations.

TL;DR: Comparison of effects of short- and long-term feeding of cholesterol-supplemented diet indicates that some lipid changes in aortic intimamedia cannot be fully explained by simple filtration from plasma.

TL;DR: The complex of pathogenetic factors for hemorrhagic encephalopathy of the rat indicates that this entity offers an excellent experimental model for study of the general problem of the pathophysiology of disturbances of blood coagulation in virus infections.

TL;DR: Control, insulin-deficient, hypertensive, and hypothyroid squirrel monkeys were fed a diet containing 1 mg of cholesterol per calorie for 3 years, and measurements were made of cholesterol absorption and serum cholesterol turnover.

TL;DR: The evidence supports the hypothesis that the loss of mitochondrial phospholipid by hydrolysis may be the cause of the ethanol-induced fragility phenomenon and that albumin may prevent fragility by binding released fatty acids.

TL;DR: The earliest histochemical change seen in those animals which would develop necrotic lesions was a loss of activity of cytochrome oxidase and phosphorylase, and the early increase of succinic dehydrogenase activity reported following isoproterenol treatment was not seen.

TL;DR: Prolonged feeding of a low protein diet to young male rats aged about 5 weeks to reproduce the syndrome of protein-calorie malnutrition found in deprived children revealed prominent changes in the submandibular salivary gland.

TL;DR: Phosphorus-poisoned rats showed an increase in the level of hepatic triglycerides, while pretreatment of these intoxicated animals with propyl gallate or glutathione lowered these values to normal levels, and N,N′ -diphenyl- p -phenylenediamine failed to affect the damage produced by phosphorus.

TL;DR: Any swine serum has been shown to have a nondialyzable component which causes DNA breakdown, a substance, largely dialyzable, which stimulates DNA synthesis, and possibly an inhibitor of DNA synthesis.

TL;DR: The presence of fibrous plaque was seen mainly in the thoracic aorta featuring small amount of fatty material in the superficial part and calcified foci at the base of the plaque.