Showing papers in "Experimental Eye Research in 2022"

TL;DR: In this paper , the authors provide a summary of several currently used in vitro RPE models, historical aspects of their development, RPE phenotypes that are attainable in these models, their ability to model different aspects of AMD pathophysiology, and pros/cons for their use in the RPE and AMD fields.

TL;DR: In this paper , the effect of αB Crystallin chaperone peptide (mini Cry) in controlling senescence in human retinal pigment epithelium (RPE) was investigated.

TL;DR: In this paper , the authors investigated how melanopsin-expressing retinal ganglion cells (mRGCs) influence normal and myopic refractive development using two mutant mouse models: Opn4−/− mice that lack functional melanopigments and intrinsic mRGC responses but still receive other photoreceptor-mediated input to these cells.

TL;DR: In this paper , the authors present evidence that visual cues appear to influence axial elongation through a retina-to-sclera, or retinoscleral, signaling cascade, capable of transmitting information from the innermost layer of the eye to the outermost layer.

TL;DR: A review of the mechanisms present on the ocular surface which impede drug delivery and methods of improving their bioavailability through viscosity and permeation enhancement can be found in this article .

TL;DR: In this paper , the authors examined the effect of topical and/or oral angiotensin converting enzyme II inhibitor and TGF-beta signaling blocker losartan on corneal stromal fibrosis that developed in rabbit corneas after Descemetorhexis removal.

TL;DR: In this paper , the authors present the state of the art on an emerging concept, the microbiota-retina axis, and the potential role of its disturbance in the development of retinopathies.

TL;DR: In this paper , the authors examined the characteristics of neuropeptides, their synthesis and their signaling through G-protein coupled receptors, and how they change in ocular and systemic diseases, including dry eye disease, ocular allergy, keratoconus, LASIK-induced dry eye, pterygium, neurotrophic keratitis, corneal graft rejection, microbial krinitis, headaches and diabetes.

TL;DR: In this article , an instant polarized light microscopy (IPOL) was used to detect stretch-induced collagen uncrimping and other elements of the tissue nonlinear mechanical behavior.

TL;DR: In this article , the effect of circFAT1 on pyroptosis and autophagy of high glucose (HG)-induced retinal pigment epithelial (RPE) cells and its molecualr mechanism was investigated.

TL;DR: In this paper , the authors examined the kinetics of microglia infiltration towards the outer retina of rhodopsin knockout mice (Rho-/-) by immunofluorescence, and undertake transcriptional and spatial localization analysis of markers for evidence of both homeostatic function and appearance of DAM.

TL;DR: A comprehensive updated review of the most relevant biomarkers of ocular surface diseases (OSDs) with an emphasis on quantitative analyses and correlations with clinical parameter data is presented in this article .

TL;DR: Exosomes are a subset of extracellular vesicles which accommodate a cargo of bioactive biomolecules that generally includes proteins, nucleic acids, lipids, sugars, and related conjugates depicting the cellular environment and are known to mediate a wide array of biological functions, like cellular communication, cellular differentiation, immunomodulation, neovascularization, and cellular waste management as mentioned in this paper .

TL;DR: In this paper , the authors provide a summary of several currently used in vitro RPE models, historical aspects of their development, RPE phenotypes that are attainable in these models, their ability to model different aspects of AMD pathophysiology, and pros/cons for their use in the RPE and AMD fields, as well as due to the burgeoning use of iPSC derived RPE cells, the critical need for developing standards for differentiating and rigorously characterizing RPE cell appearance, morphology, and function.

TL;DR: The pathophysiology of dry eye disease (DED) is complex, and therapy may be a challenge as discussed by the authors , and novel anti-inflammatory treatments may enrich our therapeutic armamentarium in the future.

TL;DR: The role of mouse double minute 2 (MDM2)-p53 axis plays a pivotal role in modulating cell cycle control and apoptosis in ocular diseases as discussed by the authors , and anti-MD2 therapy has shown potential as a novel approach to treating these diseases.

TL;DR: In this paper , the role of decorin in the regulation of stromal fibrillogenesis and corneal transparency was investigated in vivo employing a loss-of-function genetic approach using decorin null (dcn−/−) and wild type ( dcn+/-) mice and a standard alkali-injury model.

TL;DR: In this article , an overview on tear rheological behavior by analyzing the peer-reviewed literature on this topic is provided, highlighting experimental criticalities and the need of a standard convention for rheology techniques to compare data across different studies, of analyses on tears of single individuals even within the limits of the low volume available, and of a further development of in-vivo techniques.

TL;DR: In this article , the authors examined the interactions between the ocular surface and its local draining lymphoid compartment, by encompassing the corneal epithelium and myeloid cells, conjunctival goblet cells, and regulatory T cells.

TL;DR: In this article , the role and mechanism of microglia-derived tumor necrosis factor (TNF)-α in the activation of retinal Müller cells have not been fully elucidated.

TL;DR: The role of RNA-binding proteins (RBPs) in post-transcriptional gene expression control in the aging lens and in the context of age-related cataract was discussed in this article .

TL;DR: In this article , the effects of BL exposure on the behavior of RPE cells and their potential mitigation by BL-filtering intraocular lenses (IOL) were investigated, with the absence or presence of either a clear ultraviolet (UV)-filtering IOL (CIOL) or a yellow UV-and BL-filtration IOL(YIOL).

TL;DR: In this article , the melanocortin-neuropeptide alpha-melanocyte stimulating hormone (α-MSH) was used to treat experimental autoimmune uveitis.

TL;DR: In this paper, the role and mechanism of microglia-derived tumor necrosis factor (TNF)-α in the activation of retinal Muller cells have not been fully elucidated.

TL;DR: In this paper , the effect of AMD-associated genetic variants in the complement system has been investigated, and it was shown that protein QTL (pQTL) studies in plasma or serum samples may aid in understanding the effect and progression of AMD.

TL;DR: A comprehensive review of the various microRNAs (miRNAs) shown to be involved in glaucoma and intraocular pressure regulation is provided in this paper , where a comprehensive discussion of the therapeutic potential of miRNAs, the cellular pathways that link these miRNUs together, and the most promising miRNA for future glauca research are discussed.

TL;DR: This paper evaluated the effect of bovine colostrum (BC) in the regeneration of corneal epithelial cells on an ocular alkali burn model and found that topical application of BC facilitates re-epithelialization and wound healing by suppressing the inflammatory process.

TL;DR: In this paper , the effects of transient blue light exposures of various illuminances on ocular growth rates and ocular rhythms in chicks were investigated, showing that exposure to blue light at lower illuminance (less than 1000 lux) at transition times of lights-on and lights-off is associated with increased growth in chicks, suggesting that such exposures may be deleterious to emmetropization in children.

TL;DR: In this article , methacrylated gelatin (GelMA)-methacrylation of hyaluronic acid (HAMA) double network (GHDN) hydrogels were used to construct a feasible corneal substitute.

TL;DR: In this paper , the effect of Glabridin (GLD) in Aspergillus fumigatus keratitis and its associated mechanisms was investigated. And the results showed that the treatment of GLD showed significantly decreased severity of corneal inflammation, reduced number of A. fumgatus colonies in cornea, and suppressed neutrophil infiltration.