Showing papers in "International Journal of Pharmaceutics in 1983"

TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.

TL;DR: Tissue distribution, blood clearance and excretion of biodegradable cyanoacrylic nanoparticles, and the enzymatic contribution to the degradation of the nanoparticles in vivo are described.

TL;DR: In this paper, the significance of the solid-state properties of pharmaceutical powders is considered in terms of the selection of drug species and additives in formulations, and the processes involved in the manufacture of solid dosage forms.

TL;DR: In this article, a review of enthalpy-entropy compensation analysis for pharmaceutical and biochemical data is presented, where the authors describe the advantages and disadvantages of the method by using examples taken from the recent literature.

TL;DR: The physicochemical parameters of polyacrylic nanoparticles, such as the size distribution, specific surface area, density, X-ray diffraction pattern, wettability and surface charge were measured.

TL;DR: In this article, the authors studied the stability of 13 benzodiazepines with 3 cyclodextrins (α-, β-, γ-CyDs) in aqueous solution and in the solid phase.

TL;DR: In this article, the dissolution, crystal growth in aqueous milieu and pharmacokinetics of carbamazepine, as the dihydrate and anhydrate, have been studied.

TL;DR: The frequency of the different metabolization occurring in this population could be subsequently determined s approximately 6% and 13% for Groups 2 and 3, respectively.

TL;DR: For a large number of acid, base and neutral liquids and solids (including drugs) general relationships between both octan-1-ol/water distribution coefficients and isocratic reversed-phase liquid chromatography capacity factors and solute aqueous activity coefficients have been shown as mentioned in this paper.

TL;DR: It appeared that the estradiol flux from propylene glycol vehicles was unaffected by occlusion and smaller changes in the applied propylene sugar amount, and the facilitating effect could be ascribed to a change in the nature of the skin barrier.

TL;DR: The results suggest that liposomal encapsulation of the drug may be a superior drug delivery system for ocular therapy.

TL;DR: It was shown that monoclonal antibody was well adsorbed onto the surface of the nanoparticles and that it retained its capacity to bind specifically to target tumour cells in vitro for at least 4 days at 4 °C.

TL;DR: While the corneal and conjunctival absorption of a drug can be modified by its entrapment in liposome, its disposition in the intraocular tissues is unlikely to be controlled entirely by liposomes, since few, if any, of the Liposomes that may be absorbed are expected to maintain their integrity while permeating the cornea.

TL;DR: The use of parenteral fat emulsions for development of an extemporaneous preparation of an intravenous formulation of a poorly water-soluble and unstable investigational anticancer agent (NSC no. 278214) is presented in this article.

TL;DR: In this article, the adsorption of a number of non-ionic water-soluble cellulose polymers onto polystyrene lattices and ibuprofen has been investigated.

TL;DR: Doxorubicin loading capacity was determined for negative and positive liposomes prepared according to the “film” method with doxorUBicin added to the phospholipids before film formation, and a purely electrostatic mechanism of interaction between the drug and the bilayer unlikely.

TL;DR: It is demonstrated that in rabbits, variations in esterase activity with age and iris pigmentation did not alter the fraction of DPE absorbed by the eye and its adnexa at 10 min post-instillation of 0.1% DPE solutions.

TL;DR: In this paper, the influence of the polymerization conditions, such as the pH and the surfactant concentration, and of the monomer side-chain length on the molecular weight of the resulting nanoparticles was investigated.

TL;DR: In this paper, a thermodynamic evaluation of bonding in compressed tablets has been achieved providing a quantitative measure of solid paniculate interaction shown to correlate with tablet strength and the energy of formation.

TL;DR: The results indicate that when insulin was administered with a polyacrylic acid aqueous gel base containing LCFA, the absorption of insulin was promoted and the hypoglycemic effects were similar between the 3 kinds of LCFA.

TL;DR: In this paper, the effects of ionic species, inert proteins and amino acids on the extent of adsorption onto glass surfaces were also studied, and the effect of different additives, such as the phosphate ion at 0.1 M concentration and the acetate ion at0.16 M concentration, both at pH 5, were the most effective in preventing adorption on glass, plastic, tubing, syringes and filters.

TL;DR: In vitro dialysis experiments indicate that the thermodynamic activity of the drug can be increased by its incorporation within nanoparticles, and this increased activity may affect the distribution of theDrug into body tissues.

TL;DR: The constant rate of drug release from the coated beads suggests that the release of the drug was largely controlled by the permeability of nitrofurantoin through the coating.

TL;DR: In this article, the authors extend the UNIFAC group contribution method of solid-liquid equilibria to binary solvent mixtures, and compare its predictions to experimental solubilities for naphthalene in 16 different solvents.

TL;DR: It is emphasized that receptor phase metabolism due to leached enzymes may be of significance when assessing concurrent transport and metabolism of drugs or prodrugs in permeation studies using human skin.

TL;DR: Aluminium hydroxide particles have been radiolabelled with indium-113m, and incorporated into antacid preparations, and show considerable inter-subject variability in the rate of gastric-emptying of the preparations.

TL;DR: In this article, the kinetics of doxorubicin were studied in 0.01-0.5 M hydrochloric acid solutions (pH 0.4-2.1).

TL;DR: In this article, the sorption of two weak acids (warfarin and thiopentone) and two weak bases (chlorpromazine and diltiazem) into PVC containers, can be described by a constant partition model.

TL;DR: In this article, the chemical stability of methotrexate (I) in aqueous solution protected from light was studied utilizing an HPLC procedure, and the authors investigated the kinetics of degradation of degradation took place in buffer solutions at 85°C over the pH-range of 0-12.