Showing papers in "International Journal of Polymeric Materials in 2020"
TL;DR: In this article, binary and ternary blends of chitosan, gelatin, and polyvinyl alcohol can lead to hydrogels that are unsuitable for biomedical applications.
Abstract: Hydrogels produced from a single polymer show several disadvantages to biomedical applications. Binary and ternary blends of chitosan, gelatin, and polyvinyl alcohol can lead to hydrogels w...
140 citations
TL;DR: Different studies on alginate based scaffolds in the form of physically, chemically and biologically crosslinked hydrogel, sponge, fiber, micro/nano particles and 3 D printed for articular cartilage tissue engineering are discussed and reviewed.
Abstract: Many people, especially old and middle-aged, suffer from pain and disabilities caused by cartilage degradation. There are many surgical methods for cartilage treatment, however, none of the...
128 citations
TL;DR: The main objective of the present review is to emphasize its potential and present its properties along with applications in the pharmaceutical and biomedical area with a special focus on nanomedicine in cancer.
Abstract: Poly-e-caprolactone (PCL) has been the subject of extensive research in the past few years. It is widely explored in drug delivery, where the development of nanomedicines for cancer, one of the maj...
89 citations
TL;DR: In this paper, a zein/Graphene oxide composite nanofibers were fabricated and tetracycline hydrochloride (TCH) was incorporated in dressings by loading on GO nanosheets.
Abstract: In this work, zein/Graphene oxide (GO) composite nanofibers were fabricated. Furthermore, tetracycline hydrochloride (TCH) was incorporated in dressings by loading on GO nanosheets. The morphology,...
57 citations
TL;DR: The PCL-gelatin/MWNTs nanocomposite scaffold can be appropriate for cartilage tissue engineering applications and demonstrates more bioactivity and slower degradation rate than the scaffolds containing MWNTs.
Abstract: Designing scaffolds with appropriate mechanical properties is a challenge in tissue engineering. In this study the poly e-caprolactone (PCL)/gelatin with 1 wt.% of multi-walled carbon nanot...
55 citations
TL;DR: Chitosan being a natural biopolymer exhibit various properties that are useful for wound healing as discussed by the authors. But natural polymers are more effective in wound healing as compare to synthetic polymers.
Abstract: Various kinds of materials are used for wound healing. But natural polymers are more effective in wound healing as compare to synthetic polymers. Chitosan being a natural biopolymer exhibit various...
55 citations
TL;DR: The latest advances in electrospinning as a nanofiber fabrication technique for biomimetic scaffolds are reviewed, focusing on scaffolds with gradients in element and structure, 3 D nan ofiber scaffolds, and hydrogel scaffolds incorporated with nanofibers.
Abstract: Fibrous microstructure has drawn extensive attention in tissue engineering due to its common presence in connective and muscle tissues. This paper reviews the latest advances in electrospinning as ...
54 citations
TL;DR: In this article, the industrial and environmental challenges have attracted considerable interest in different conducting polymer based bio nanocomposite for different applications, and these composites are comprised of ouroborobes.
Abstract: The industrial and environmental challenges have attracted considerable interest in different conducting polymer based bio nanocomposite for different applications. These composites are comprised o...
41 citations
TL;DR: This paper elucidates recently emerging trends in ECPBs, CH, novel applications in the biomedical field, and other relevant areas.
Abstract: Recently electrically conducting polymeric bionanocomposites (ECPBs) have emerged as materials for use in biomedical, food and agricultural engineering due to their inherently plastic and biodegrad...
37 citations
TL;DR: This review summarizes the microgel based scaffolds specifically for bone tissue engineering and explores the success in recreating potential bone regenerative scaffold for clinical applications, future perspectives and its concurrent view has been deliberated in detail.
Abstract: Microgels have recently gained exposure as a potential scaffold either alone or in combination with other scaffold for bone tissue engineering. Microgel has been defined as a small size particle of...
32 citations
TL;DR: The data showed that composite hydrogels containing silk fibroin/halloysite nanotubes loaded with vancomycin can be considered for treatment of bone infection.
Abstract: Despite the progress in antibiotic treatment, it is still challenging to promote bone regeneration in the case of chronic bone infection. Here, we synthesized composite hydrogels containing...
TL;DR: In this paper, the authors describe a method to incorporate biocompatible materials in nano-fiber yarns, such as tunable porosity and high surface to volume ratio.
Abstract: Electrospinning fabricates nano dimensional fibers exhibiting characteristics such as tunable porosity, high surface to volume ratio and the ability to incorporate biocompatible materials in nano f...
TL;DR: This update introduced basic concept of polymer drug conjugate (PDC) (prodrug) and provided an overview on currently used synthetic strategies for PDCs and brief overview on various polymer-drug conjugates updating their clinical status and highlights with major anticipated clinical application in cancer therapy.
Abstract: The majority of anti-cancer drugs show poor water solubility and produce adverse effects in healthy tissue. The combination of polymer technology and targeted drug delivery system may overlay the w...
TL;DR: A hybrid composite of silk fibroin (SF)/hydroxyapatite (HA) nanofibrous mats was directly electrospun on titanium plates in order to mimic the bone extracellular structure and improve osteoconductivity and exhibited a strong interfacial attachment and homogenously dispersed HA nanoparticles in the electrospuns.
Abstract: Improving osseointegration together with preventing infections are the main challenges of using titanium-based implants in joint replacement surgeries. In this study, a hybrid composite of silk fib...
TL;DR: In this paper, the authors present a comprehensive analysis of common biomaterials application in the field of regenerative medicine, focusing on tissue engineering, drug delivery and wound wound wound care.
Abstract: There is need to advance the field of regenerative medicine through a comprehensive analysis of common biomaterials application. Since lots of studies on tissue engineering, drug delivery and wound...
TL;DR: A review of the development of bioresorbable polymeric composites for applications in tissue engineering is presented in this article, with emphasis on the use of bioresobable polymers.
Abstract: This review covers the development of bioresorbable polymeric composites for applications in tissue engineering. Various commercially available bioresobable polymers are described, with emphasis on...
TL;DR: Osteoblast cell culture showed PGA scaffolds to effect a dose-dependent increase in alizarin red, demonstrating a facile method to obtain 3 D plotted constructs for bone tissue engineering.
Abstract: Alginate is the most commonly explored biomaterial used for extrusion printing though it provides limited cell-material interactions. Thus, bioink functionality is improved by blending with...
TL;DR: This work investigated the preparation of cisplatin (CP) loaded Tragacanth Gum (TG)-lecithin (LC) nanogels by nanoemulsion process, which exhibit polygonal core-shell structure in which CP particles are embedded in the TG core of the nanogel and remain covered by LC as shell.
Abstract: Nanogels are functional particles that may be used to deliver bioactive molecules in targeted drug delivery systems. In the present work, we have investigated the preparation of cisplatin (CP) load...
TL;DR: The advances and applications of natural/synthetic polymeric carriers have been summarized in gene therapy and disadvantages/challenges have been also discussed.
Abstract: Gene delivery systems necessitate the gene therapy, which is a unique approach for applying the tunable genes to treat any diseases. To tackle down the disadvantages of viral vectors like high cost...
TL;DR: In this article, 3D porous electrospun scaffolds based on DegraPol® (DP), a polyester urethane, with different concentrations of graphene oxide (GO) (0.0 − 2.0 ) were obtained.
Abstract: In this work, 3D porous electrospun scaffolds based on DegraPol® (DP), a polyester urethane, with different concentrations of graphene oxide (GO) (0.0–2.0 wt%) were obtained. In order to produce sc...
TL;DR: In this paper, a macroporou...To improve mechanical strength, polyvinyl alcohol hydrogels were often prepared through freeze-thaw method, however, they usually exhibited micropores limiting their applications.
Abstract: To improve mechanical strength, polyvinyl alcohol hydrogels were often prepared through freeze-thaw method. However, they usually exhibited micropores limiting their applications. Hence, macroporou...
TL;DR: In this paper, a β-cyclodextrin-grafted silk fibroin (SF) nanofibers were successfully fabricated and the morphology and diameter of the electrospun nanofiber were characterized.
Abstract: A novel β-cyclodextrin-grafted silk fibroin (SF) nanofibers was successfully fabricated. The morphology and diameter of the electrospun nanofibers were characterized. FE-SEM images showed t...
TL;DR: In vitro microscopic images of the fibroblast NIH 3T3 cell lines revealed the biocompatibility, cell viability, cell adhesion, and proliferation of biopolymer film in the wound site.
Abstract: A biopolymer film serving as a wound-healing substitute was fabricated using keratin and fibrin (extracted from a goat hoof and blood, respectively) via modified Shindai techniques. The importance ...
TL;DR: In this paper, boric acid loaded chitosan (CS) and collagen-based hydrogels were prepared, and four different boric acids concentrations were used to load CS and collagen.
Abstract: In the current study, boric acid loaded chitosan (CS) and collagen-based hydrogels were prepared. Hydrogels with four different boric acid concentrations were prepared; control hydrogel (wi...
TL;DR: Novel PCL/P-188(Shell) coaxial scaffold had superior stability, average weight loss, no swelling behavior, controlled release of Beta-lactoglobulin and vitamin K2, enhanced Saos-2 cell viability and ALP activity and could be a good candidate as a bone tissue scaffold.
Abstract: Structure of fibrous scaffolds varies depending on the electrospinning method and parameters which will define cell fate. In this study, monoaxial and coaxial electrospun PCL/gelatin/P-188 ...
TL;DR: The pharmacokinetic study revealed that oral bioavailability of Linagliptin was enhanced by SLN’s when compared to the pure drug.
Abstract: Linagliptin is a DPP-4 Inhibitor used in the treatment of Type II Diabetes. One of the major disadvantages of this drug is low bioavailability. To overcome this challenge a new drug delivery has be...
TL;DR: The use of polymeric materials in biomedical applications has been growing exponentially as discussed by the authors and this phenomenon is due to progress in areas such as polymeric material science, tissue engineering, pharma, etc.
Abstract: The use of polymeric materials in biomedical applications has been growing exponentially. This phenomenon is due to progress in areas such as polymeric materials science, tissue engineering, pharma...
TL;DR: Shape-memory characteristics shed light on materials science and open horizons for accessing to unconventional functions in material categories subsuming metals, polymers, and ceramics as discussed by the authors...
Abstract: Shape-memory characteristics shed light on materials science and open horizons for accessing to unconventional functions in material categories subsuming metals, polymers, and ceramics. Biomedical ...
TL;DR: Self-healable polymeric hydrogels as mentioned in this paper demonstrate the ability of self-healing in biomedical applications by exhibiting crosslinking and high rheology with high water composition and utilized for biomedical applications.
Abstract: Hydrogels are polymer networks which exhibit crosslinking and high rheology, with high water composition and utilized for biomedical applications. Self-healable polymeric hydrogels demonstrate the ...
TL;DR: In this article, the synthesis and characterization of thiol functionalized reduced graphene oxide (TrGO) as a novel platform for loading of anticancer drug methotrexate (trGO-MT) was presented.
Abstract: The present investigation emphasizes on synthesis and characterization of thiol functionalized reduced graphene oxide (TrGO) as a novel platform for loading of anticancer drug methotrexate (TrGO-MT...