Showing papers in "Journal of Investigative Dermatology in 1984"

TL;DR: Results show indirect immunofluorescence on separated skin is a dependable method for differentiating bullous disease anti-lamina lucida and anti-sublamina densa antibodies and that differentiating between the antibodies is essential for accurate diagnosis in some patients.

TL;DR: It is reported here that pure recombinant human gamma interferon induces HLA-DR expression on 60-70% of cultured human adult keratinocytes depleted of LC within 2-4 days of culture as determined by fluorescence-activated cell sorter (FACS) analysis using monoclonal antibodies.

TL;DR: The present study indicates that EGF may have a more complex regulatory role in the skin than was previously thought.

TL;DR: The in vivo thickness of the stratum corneum, its water concentration profile, and the flux of water (transepidermal water loss) at environments of different relative humidities are calculated.

TL;DR: HPV types 16 and 18 have been identified in two different human cervical carcinomas and a similar distribution of the different papillomaviruses was observed when cell swabs taken from the cervix were tested by in situ hybridization.

TL;DR: Under appropriate conditions, AA-induced ear edema can be used as a model to screen for compounds showing in vivo lipoxygenase inhibitory activity and additional factors appear to be required to produce a prolonged inflammatory response with associated tissue destruction, or inflammatory cell activation and immobilization in situ.

TL;DR: The results of this study indicate that within the epidermis there are at least two cell populations, keratinocytes and LC, that can constitutively secrete potentially important soluble immunostimulatory factors.

TL;DR: Findings suggest that leukotriene B4 and Monohydroxy-eicosatetraenoic acid-like activity was seen in lesional samples as determined by straight-phase HPLC and chemokinesis assay and may play a role in the pathogenesis of the psoriatic neutrophil infiltrate.

TL;DR: Results suggest that immunoperoxidase staining for involucrin may be useful in distinguishing certain benign from malignant epidermal neoplasms as well as in understanding the altered maturation and kinetics of proliferative processes afflicting keratinocytes.

TL;DR: These experiments provide further evidence for the role of leukotriene B4 in the pathogenesis of psoriasis, and may lead to the development of an experimental model of the inflammatory events in psoriatic skin lesions, and of a simple in vivo test of neutrophil function.

TL;DR: Selective growth and long-term maintenance of melanocytes derived from both newborn and adult skin specimens are reported, and this system promises to facilitate in vitro investigation of epidermal melanocytes in normal and diseased human skin.

TL;DR: It is demonstrated that the pemphigoid antigen can be extracted directly from normal human skin and is a molecule similar in molecular weight to the antigen synthesized in human epidermal cell culture.

TL;DR: A kinetic model for epidermal cell renewal in normal epidermis is described that interrelates the rate of birth/entry, transit, and/or loss of keratinocytes in the 3Epidermal compartments: proliferative, viable differentiated (stratum malpighii ), and stratum corneum.

TL;DR: EV serves as a model for studying the interplay of oncogenic viruses, genetic and immunologic factors, and sunlight in the production of skin cancer in humans.

TL;DR: Indirect immunofluorescence studies on mechanically induced suction blisters in skin of 2 patients with in vivo-bound IgG suggest that the lamina lucida antigen involved in cicatricial pemphigoid may be distinct from the bullous pemPHigoid antigen.

TL;DR: Human skin chymotryptic proteinase, cathepsin G, and tonin provide unique pathways for the generation of angiotensin II in tissue and may be of significance in regulation of biologic processes of the tissue microenvironment.

TL;DR: Sphingolipid profiles have been determined for whole epidermis, a subcellular fraction enriched in lamellar granules, and a fraction enriched with stratum corneum derived from fetal rat skin and the possible functions of these sphingolIPids in the assembly and structure of lamellary granules are discussed.

TL;DR: Ninety-three primary malignant melanomas of the skin were typed immunohistologically for the expression of HLA-DR on tumor cells and the majority of tumors that had metastasized within an observation period of 0-32 months were Hla-DR-positive.

TL;DR: These studies suggest that KPase from C. albicans may play an important role in superficial infection by affecting the human stratum corneum of the skin and nail.

TL;DR: In this paper, the Langerhans cell populations in the skin of young persons with no evidence of solar damage and older adults with chronic actinically damaged skin were examined and the results suggest an independent, although possibly additive, quantitative and qualitative influence of aging and chronic sun exposure on the LC population.

TL;DR: The reactions of the tested subjects to the surfactants suggest that each individual has his own pattern of susceptibility to these substances.

TL;DR: Results show that aged skin has a lower water content than the skin of younger men and both the propagation velocity and attenuation of shear waves in skin are highly dependent upon the water content of the stratum corneum.

TL;DR: Analysis of vital signs for days 1 and 2 revealed no systemic effect from treatment with minoxidil, suggesting that the blood flow stimulation was directly related to the topical application of minoxIDil.

TL;DR: The presence of melanosomes as single, membrane-bound granules in all stages of melanization confirms that the melanin-containing dendritic cells of the leptomeninges are melanocytes and not macrophages.

TL;DR: The finding that slowly cycling keratinocytes are related to patterns of tissue architecture is compatible with a function of these cells as epithelial stem cells.

TL;DR: It is suggested that OIs generated by UVR participate in SC formation but are not apparently involved in UV-edema.

TL;DR: The data are discussed in terms of a possible role for the EGF receptor and associated EGF or EGF-like ligands in specific areas of epithelial tissue morphogenesis during embryonic skin maturation, hair follicle development, and hair cycling.

TL;DR: This enzyme, prepared from mouse melanoma, catalyzed the conversion of dopachrome to 5,6-dihydroxyindole and also appeared to block the pigment pathway at this latter compound in the absence of tyrosinase.

TL;DR: Modified ATPase histochemistry was used to identify and count Langerhans cells (LC) in autopsy tissue from 8 oral mucosal sites, 8-20 h postmortem, and the number of LC in nonkeratinized oral mucosa is approximately the same as in skin, but keratinized Oral mucosa has fewer LC.

TL;DR: The results suggest that LTB4 is a specific chemoattractant for fibroblasts and that it acts in concert with other chemotactic factors derived from inflammatory leukocytes to regulate the influx of fibro Blasts to tissue sites.