Showing papers in "Journal of the Neurological Sciences in 1971"

TL;DR: The uneven reduction of dopamine and serotonin appears to preclude the possibility of a defect in the transport of precursor amino-acids into brain and in the synthesis, storage, and degradation of the monoamines in Parkinson's disease.

TL;DR: In the animals surviving 4 months or longer the end-plates of soleus fibres were similar to the normal for that muscle though nerve terminals were scattered along muscle fibres and many had no sole-plate nuclei near them and in gastrocnemius some end- plates were normal in appearance but others had unusually few and shallow subneural folds.

TL;DR: Dystonic movements and postures were analysed with surface electromyography in idiopathic dystonia musculorum deformans and responses to passive stretch and isometric voluntary contraction were observed in neck, trunk and extremity muscles.

TL;DR: There is a preponderance of changes strongly suggesting that there is a progressive process of denervation and reinnervation of limb muscles occurring with increasing age, particularly in the EDB, which was exceptional.

TL;DR: There is no evidence that the condition has a neuralgic basis, and it is suggested that the misleading designation “migrainous neuralgia” be replaced by the descriptive term “cluster headache”, until such time as the aetiology is fully understood.

TL;DR: The pathogenesis of multiple cranial nerve involvement is obviously entrapment and rarely infiltration by the basal exudate of the cranial nerves in and around the interpeduncular fossa.

TL;DR: The need for caution is indicated in concluding that large groups of muscle fibres of one histochemical type in human limb muscles necessarily indicate denervation and subsequent reinnervation.

TL;DR: Nerve conduction studies were performed on the median, ulnar, and lateral popliteal nerves of 8 patients with Friedreich's ataxia, finding significant slowing of motor conduction, and impairment of sensory conduction.

TL;DR: Porto-caval anastomosis has been performed in rats in order to produce an increase in the plasma ammonium-nitrogen and changes occurred in the nuclei of astrocytes from about the fifth week onwards, where nuclei showed increasing lobulation with the formation of bizarre shapes.

TL;DR: In this paper, the pathogenesis of delayed radiation lesions of the spinal cord is discussed in relation to recent experimental data, and the most important factors for the delayed radiation myelopathy are suggested as the biochemical induced lesions of oligodendroglia and damage to the vascular endothelium together with secondary permeability disorders of the blood-brain barrier.

TL;DR: Over a 12-year period at University College Hospital, Ibadan, 9600 patients suffering from neurological diseases have been seen out of 220,000 patients investigated in the wards and specialty clinics, and various aetiological factors were encountered, the commonest being malnutrition.

TL;DR: There has been a decreasing incidence over time of both cranial neuropathy and of the overall severity of the illness in this series, and diagnostic criteria for the GBS favoring a more comprehensive definition than any previously suggested are proposed.

TL;DR: A sublethal dose of botulinum toxin was injected into the calf muscles of one leg in mice and caused paralysis of those muscles within 24-hour. Recovery from paralysis took place after several weeks as discussed by the authors.

TL;DR: A correlation of the clinical features of the ophthalmoplegia with other clinicopathological and experimental observations would suggest that essential structures subserved by the above pathway include the posterior commissure and its interstitial nuclei, including certain cell groups scattered among its diverging fibres.

TL;DR: The electrical signs of nervous activity that will be your best choice for better reading book and how to take the book as a source to make better concept is shown.

TL;DR: It is suggested that this drug has a non-specific depressant action on spinal synapses, its effect therefore being manifested in polysynaptic pathways, possibly by activation of “presynaptic” inhibitory mechanisms.

TL;DR: A potent COMT inhibitor (N-butyl gallate, GPA 1714) has been found effective in counteracting the toxic dose-related side-effects of l -Dopa therapy in patients with Parkinsonism and in relieving involuntary movements in a small group of patients with Huntington's chorea and spasmodic torticollis.

TL;DR: There is no firm evidence that obstructive hydrocephalus operating as the only pathogenetic mechanism can reduce the cerebrum to membrane thickness within a cranium of relatively normal size, and the finding of a transilluminable cr skull of normal size indicates the probability of an underlying destructive process or malformation.

TL;DR: This observation supports the concept that tardive dyskinesias are related to hypersensitivity of dopaminergic receptors to dopamine and is suggested that Levodopa should be avoided in patients with neuroleptic-induced lingual-facial-buccal Dyskinesia.

TL;DR: It is concluded that the most important factor is the reinnervation of muscle fibres by collateral sprouts from the axons of surviving motoneurones in chronically denervated muscle.

TL;DR: The electron microscopic appearance of muscle fibres and their end-plates in soleus have been compared with those in the peripheral part of gastrocnemius in the normal mouse and differences between the two muscles were seen in respect of Z-lines, M- lines, mitochondria and tubules.

TL;DR: These findings are in general conformity with the hypothesis that a disturbance to microtubular metabolism in the brain occurs in association with high plasma ammonium levels, probably due to reduction in size of the glutamate and aspartate pools in glial cells.

TL;DR: The view (Walton et al. 1969) that the use of a battery of tests is more likely to provide maximal carrier detection than the continued refinement of a single test still holds despite the present pre-eminence of the serum CK estimation.

TL;DR: Autopsy material obtained from 8 adult patients who had died suddenly was used in order to compare the sizes of the two main histochemical fibre types in several skeletal muscles, finding that Type I fibres in the quadriceps and to a lesser extent in gastrocnemius are probably relatively larger.

TL;DR: The lesions obtained in vitro with some GBS sera, in the absence of mononuclear cells, have thus some similarities with those observed in the nerve fibres in vivo but the precise role of this serum factor in cases of this disease remains to be elucidated.