Showing papers in "Kidney International in 1972"

TL;DR: It is concluded that the urine from the subjects when salt-loaded contains a natriuretic substance.

TL;DR: Normal values for plasma renin activity (PRA) were defined in 52 normal subjects over the range of physiological variation which occurs in relation to changes in sodium balance, and physiologically, changes in substrate concentration are not normally determinants of the rate of angiotensin generation.

TL;DR: Renal handling of calcium and phosphate during mineralocorticoid "escape" in man suggests decreased sodium transport in the proximal tubule may be associated with phosphaturia since phosphate is mostly unreabsorbed distally, while decreased sodium reabsorption in the distal tubules may occur with calciuria only.

TL;DR: This model is based largely on transport characteristics obtained by perfusing isolated segments of rabbit nephrons in vitro, and allows the entire system to operate by passive diffusion of NaCl out of the thin ALH.

TL;DR: Concentration of urine in a central core model of the renal counterflow system with Urea cycling, regulated by ADH, allows active Na + transport in the outer medulla and cortex to be used for concentration in the inner medulla.

TL;DR: Data provide support for the view that the adaptation in P excretion imposed by a constant P intake and a decreasing nephron population plays an important role in the pathogenesis of secondary hyperparathyroidism and suggest that if the necessity for the adaptation is obviated, hyperparathiroidism may be prevented, at least until the onset of vitamin D resistance.

TL;DR: In order to understand all the pathophysiological mechanisms involved in the effect of acid-base changes on the heart, the peripheral vessels, the lungs, and the diffusion of oxygen between air, blood, and tissues, it is necessary to understand the effects of changes in pH on each step in the chain.

TL;DR: Overall mortality was reduced by prophylactic hemodialysis from 42% (Group I) to 29% ( Group II), and it was significantly lower in all patient categories: post-surgical, post-trauma, and post- Trauma.

TL;DR: In contracted kidneys, the cortical arterial tree was destroyed by obliteration of the cortical A–G units whereas the medullary A-G units became continuous and were relatively well preserved, thus maintaining the Medullary circulation.

TL;DR: Coagulation is of importance in two groups of disorders in man: the kidney is the major site of disease and localized thrombosis and fibrin deposition is superimposed on demonstrable immunological or other endothelial damage.

TL;DR: The mechanisms that serve normally to regulate pH, as well as the whole spectrum of functional disturbances that result from the changes in body fluid pH produced by stress or disease, will probably all find their ultimate explanations in these terms.

TL;DR: The present paper will be concerned with the factors involved in the generation and maintenance of metabolic alkalosis, andPhysiologic determinants will be explored and clinical derangements will be examined.

TL;DR: It is concluded that active Na transport is augmented by vasopressin in the collecting tubule, similar to the effect previously observed in anuran membranes.

TL;DR: The time-course of generation of the 3 H-aldosterone-labelled cytosol and nuclear receptor species was studied in vivo and in vitro and imply a close association between nuclear aldosterone-receptor complexes and intact DNA.

TL;DR: A review of the regulatory mechanisms for the regulation of the cerebrospinal fluid pH can be found in this paper, where different possible regulatory mechanisms are described and examined without any serious attempt to establish their quantitative importance.

TL;DR: Long-term saline loading prior to the induction of myohemoglobinuria appears to prevent acute renal failure by abolishing sustained renal cortical ischemia.

TL;DR: Na and water re absorption were reduced in the proximal and distal nephron, distal K secretion was increased, and a marked defect in concentrating ability was present, and the reduction in proximal Na reabsorption was not associated with a reduced peritubular capillary protein concentration.

TL;DR: The results give the morphological counterpart of the influence of angiotensin on the glomerular capillaries and are in keeping with a redistribution of the cortical renal blood flow.

TL;DR: It appears that in aminonucleoside-induced nephrotic animals, at least, alterations in colloid oncotic pressure of the degree obtained in these experiments are not important to the regulation of proximal tubule fractional water absorption.

TL;DR: Renin activity was measured in superficial and juxtamedullary JGA's of rats maintained on a standard diet, or rats that were sodium-loaded or sodium-deprived, this difference was not significant statistically.

TL;DR: In this paper, the authors examined the influence of distal sodium delivery upon glomerular hydrostatic pressure utilizing a servo null pressure device in Wistar rats with surface glomeruli on normal NaCl diet and during saline diuresis.

TL;DR: It is concluded that the defect in U max is not the result of diminished glomerular filtration rate nor a defect in sodium reabsorption in the ascending limb of Henle's loop, and may result from alterations in collecting duct function or medullary architecture due to the presence of cysts.

TL;DR: Serial studies revealed the long term persistence of subepithelial deposits and in patients who survived, subendothelial deposits disappeared with time and treatment.

TL;DR: It is concluded that the increased fractional excretion of sodium and diminished urine osmolality observed in chronic obstructive nephropathy result from decreased reabsorption in the distal nephron and/or impaired function of the deep nephrons and renal medulla.

TL;DR: The data presented suggest that the inborn error of connective tissue metabolism of the nail-patella syndrome is associated with renal disease as the result of deposition of collagen moieties in glomerular basement membranes with subsequent alterations ofglomerular structure and function.

TL;DR: The number of glomeruli per kidney (NG) was determined using Damadian's method in hypertrophic kidneys removed 20 to 36 days after a contralateral nephrectomy in young rats using Damadan's method.

TL;DR: It is concluded that net fluid absorption of proximal tubules is relatively independent of the difference in either hydrostatic or oncotic pressure between the tubular lumen and peritubular fluid, and it is suggested that per itubular serum proteins may influence net absorption at the antilumenal side of the epithelial cell, perhaps by facilitating the movement of absorbate across thetubular basement membrane.

TL;DR: Results compare favorably to those obtained with receptor molecules from other estrogen-responsive tissues and provide presumptive evidence for the involvement of renal estradiol receptor sites in the effect of estrogens on sodium excretion.