Showing papers in "Kidney International in 1979"

TL;DR: Evidence is analyzed regarding the extent, pathways, and mechanisms of the renal accumulation, filtration, absorption, and metabolism of small proteins, a heterogenous group of substances which constitute a small but biologically important fraction of total circulating proteins.

TL;DR: The first description of the incidence and recurrence rates for symptomatic noninfected renal stones in a well-defined population of Rochester, Minnesota, between 1950 and the end of 1974 is described.

TL;DR: These studies indicate that stimulation of the emetic reflex results in AVP-release in man and rat, and indicates that Nausea-mediated AVP release supervenes over concomitant osmolar or pharmacologic inhibition.

TL;DR: Results indicate that gentamicin is transported into the proximal tubule cell by pinocytosis and becomes sequestered in lysosomes and may account for the accumulation of myeloid bodies in the proximate tubule lyssomes of gentamicIn-treated rats, but whether this mechanism contributes the nephrotoxicity of this drug cannot be ascertained.

TL;DR: Data demonstrate the presence of a component of tubular calcium reabsorption situated beyond the proximal tubule, which is inhibited by chronic (but not acute) metabolic acidosis and enhanced by metabolic alkalosis (or bicarbonate infusion) independently of parathyroid hormone.

TL;DR: Immunoelectron microscopy has shown that this protein is localized selectively along surface membranes of the thick ascending loop of Henle, and the unique aggregation and gel formation of Tamm-Horsfall protein in response to increasing concentrations of electrolytes within physiologic ranges may influence the permeability characteristics of this nephron segment.

TL;DR: The rate of IHD in dialysis women was greater than it was in nondialysis subjects, and coronary artery disease only affected long-term survival of patients with preexisting disease; and autopsy data did not suggest accelerated atherosclerosis.

TL;DR: The present results suggest that the calcium ion may be an important cofactor required for the expression of AII action on the glomerular microcirculation, by affecting mesangial and efferent arteriolar smooth muscle contractility.

TL;DR: A moderately restricted protein diet securing only the minimal requirements had a beneficial effect on growth and survival of rats with reduced kidney mass, and avoiding any excess in proteins from the early stage of renal disease is suggested.

TL;DR: Probenecid pretreatment in man increased the overall response to furosemide in contrast to animal studies in which probenecid decreased response by inhibiting proximal renal tubular secretion of furoSemide to its active site.

TL;DR: The kidney plays an important role in the metabolism of proteins and peptides, and current evidence indicates that only the proximal tubule possesses the mechanism for degradation or transport of these substances and reabsorption of metabolic products.

TL;DR: Neurobehavioral measures that are relevant to uremic symptomatology provide quantitative estimates of the clinically significant, whole-organism biologic effects of renal failure and its several treatments.

TL;DR: It is suggested that glomerular immune deposits may be less important than other factors in determining the extent of renal injury and subsequent clinical course in crescentic glomerulonephritis.

TL;DR: It is suggested that early renal biopsies may be helpful in predicting prognosis in the "hemolytic-uremic syndrome," which may occur either in apparently healthy people, or may complicate the course of a chronic essential hypertension.

TL;DR: A heretofore unappreciated morphologic similarity between the models and human disease is delineated and added further support to the hypothesis that partial rubular obstruction participates in the pathogenesis of renal cystic disease, whether it be heritable or acquired, in animals and in man.

TL;DR: It is concluded that partial nephron obstruction exists in NDGA-exposed kidneys and that obstruction is a likely contributor to cyst formation in this model.

TL;DR: Recovery from postischemic acute renal failure occurred in a biphasic pattern, with the initial rise in CIn associated with the relief of intratubular obstruction, whereas subsequent rises in C in occurred in association with progressive renal vasodilation.

TL;DR: It is concluded that regional heparinization has no clinical or practical advantage over low-total-dose heparins in preventing bleeding associated with hemodialysis.

TL;DR: A method is described that can measure renal clearances and extraction of PAH accurately and repeatedly in the same conscious rat over a period of weeks and is usable in unanesthetized rats.

TL;DR: Observations support the view that the CNT is functionally distinct from either the DT or the CCT, which is located between the distal (DT) and the cortical collecting tubule (CCT).

TL;DR: To examine more closely the development and mechanism of the abnormalities in albumin excretion emerging during exercise in diabetes and to evaluate a new kind of provocation test for protein excretion in similar groups of patients, inhibition of tubular protein reabsorption by the use of lysine is evaluated.

TL;DR: A model that treats the capillary wall as a barrier containing uniform cylindrical pores, and permeating solutes as hard spheres, is shown to be successful in describing the size-selectivity of the glomerulus.

TL;DR: An experimental model of glomerulonephritis was produced by the in situ formation of immune complexes directly in the glomerular capillary wall of rats by perfusing the lectin concanavalin A into the left renal arteries of rats, and the quantitative relationship between antigen and antibody binding and histologic outcome was determined.

TL;DR: The clinical spectrum of renal manifestations, renal pathologic changes, and pathogenesis will be presented and it is shown that renal involvement in falciparum malaria varies widely.

TL;DR: D dopamine plus furosemide have a synergistic effect in preventing the early pathophysiologic changes associated with ARF in this animal model and maintenance of a high GFR correlated best with the enhancement of solute excretion and urine flow rate.

TL;DR: It is concluded that BJP of pI greater than urine pH are acutely nephrotoxic in the rat by a mechanism that may involve a charge interaction in the distal nephron.

TL;DR: The polysaccharide macromolecules are readily available; they can be refined to give a defined molecular radius; most importantly, they are neither reabsorbed nor secreted by the tubules, so the charge on thesepolysaccharides can be controlled, but not the changes in their structure.

TL;DR: The renal accumulation of Gentamicin reflects transport of gentamicin across both the apical and basolateral membranes of proximal tubular epithelium, and argues against a rapid transtubular secretory flux of gentomicin.

TL;DR: PRA increased during ultrafiltration due to hypovolemia and decreased during dialysis, presumably due to decreased sympathetic activity which may also be a cause of dialysis-induced vasodilation.

TL;DR: These studies demonstrate that there are several types of pharmacologic agents which can modify the magnitude of renal functional impairment resulting from extreme renal ischemia and are compatible with the view that the protective effect noted with PGE, bradykinin, mannitol, and furosemide may be related to an increase in osmolar excretion which occurred with administration of each of these agents.