Showing papers in "Laboratory Investigation in 1982"

TL;DR: This review surveys cellular sources of free radicals and the reactions they can undergo and discusses cellular defenses and adaptive mechanisms.

TL;DR: The results suggest that Ulex europaeus I agglutinin is a good histologic marker for endothelium in human tissues.

TL;DR: This review will examine evidence obtained in a variety of in vitro model systems demonstrating the ability of intact phagocytes to generate oxygen metabolites capable of destroying normal or neoplastic cells.

TL;DR: The present study supports in a different animal model the concept that both morphologic changes and proteinuria are the consequence of a common primary event that is the loss of glomerular fixed negative charges.

TL;DR: It is indicated that patients with unilateral renal agenesis are significantly more likely to develop focal and segmental glomerulosclerosis (FGS) in their solitary kidneys than patients with two kidneys.

TL;DR: It is demonstrated that AGEPC has potent vasoactive properties and additional information is provided that implicates this acetylated alkyl phosphoglyceride as a mediator of the acute inflammatory process.

TL;DR: Results indicate a smooth transition of helix angle from epi- to endocardial surface in the normal left ventricular free wall with nearly 55 per cent of the wall occupied by circumferentially oriented fibers near the cardiac equator.

TL;DR: Amyloid-enhancing factor is a transferable activity that in CBA/J mice reduces the induction time of splenic amyloid deposition to 48 hours, and tentative identification by disc electrophoresis has been made.

TL;DR: The S-100 protein and GFAP-related antigen may be actively synthesized in adenoma cells during the course of tumor development and is considered to be a tumor-associated antigen of pleomorphicAdenoma of the salivary glands.

TL;DR: Type I alveolar epithelial cells proliferate mainly in areas of less severe degrees of fibrosis; cuboidal cells become the main source of epithelial renewal in Areas of very severe lung damage.

TL;DR: Kupffer cells show a functional heterogeneity that is related to their position in the liver acinus and this zonal heterogeneity can be reduced after phagocytosis of a triggering dose of latex.

TL;DR: Reduced tumoral glycosyltransferases may explain this increased synthesis of TAg in cancers as compared with controls, if one considers TAg to be an incomplete glycoprotein of the MN blood group system.

TL;DR: The data suggest that local proliferation by resident macrophages in monocytopenic and intact mice is an important mechanism of population renewal.

TL;DR: Since the mouse is a highly accessible species that is immunologically well understood, this model might lend itself to fuller dissection of autoimmune events associated with recurrent demyelination, problems of considerable significance to multiple sclerosis research.

TL;DR: It is hypothesized that the neurofibrillary changes in this genetic disorder in dogs is associated with an abnormality of the cytoskeletal constituents of motor neurons.

TL;DR: Since long-term endothel cell cultures derived from the cerebral microvasculature retain characteristic endothelial cell markers and in vivo markers andIn vivo features of brain capillary endothelium, they can serve as a useful model system to characterize microvascular endothelia in a variety of disease states.

TL;DR: The data indicate that estrogens promote hepatic neoplasia, perhaps by increasing hepatocyte mitotic activity and thereby facilitating the evolution of previously initiated cells into neoplastic clones.

TL;DR: The findings suggest that the increased amounts of sulfated GAGs detected chemically in colon carcinoma can be explained by the presence of a larger number of smaller proteoglycan granules packed more closely together in the intercellular matrix.

TL;DR: Results indicate that lysosomes are able to internalize their membranes during in vitro incubation followed by degradation of the micropinocytosed proteins.

TL;DR: There are two distinct stages in the development of this synovial disease--the first is characterized by hyperplasia and fibrin deposition, and the second by the presence of inflammatory infiltrates.

TL;DR: To approach the in vivo situation an in vitro model for the microcirculation was developed that uses endothelium cultured on microcarrier beads, which is used for studies of the binding of thrombin and platelet factor 4, for the demonstration of anticoagulant properties of the cells.

TL;DR: The results suggest that after endothelial injury either only vimentin-containing smooth muscle cells are responsible for replication and migration into the intima, or that smooth Muscle cells, while migrating into theintimal thickening, synthesize only vimentsin.

TL;DR: The authors' results clearly document changes in endothelial morphology during the early stages of coronary atherosclerosis, which are discussed with respect to the role the altered cells may play in disease progression.

TL;DR: Endothelial cells, but not smooth muscle cells, are restricted to the surface of collagen gels, which may be related to the synthesis of a smooth muscle collagenase.

TL;DR: It is proposed that the events reported here represent normal, steady state clearance of a subpathogenic dose of potentially toxic particulates.

TL;DR: Using platelets prelabeled with 51Cr, this work quantified the effect of injury to the neointima on platelet accumulation, thrombus formation at different times following injury, and the effect on platelets survival after injury.

TL;DR: Three metastases to the abdominal region from tumors originating in the ovary, stomach, and large bowel were like the primary tumors in that the tumor cells were positive when stained with antibodies to prekeratin and negative when tested with the antibodies to vimentin.