Showing papers in "Laboratory Investigation in 1986"

TL;DR: A method of embedding 100 or more different tissue samples in a normal-sized paraffin block, the multitumor tissue block (MTTB), which allows the simultaneous immunohistologic testing of numerous tissue samples on a single slide with one drop of antibody.

TL;DR: It is indicated that CyA exerts a direct cytotoxic effect on endothelial cells and might help in understanding the pathogenesis of CyA-induced vascular damage.

TL;DR: Results demonstrate that damaged conduit arteries can exist in a stable state without endothelium and do not develop thrombosis even after prolonged periods of time.

TL;DR: The results of this study suggest that the temporally ordered synthesis of specific matrix components plays a significant role in orchestrating the growth and differentiation of endothelial cells during the highly integrated set of responses known as angiogenesis.

TL;DR: It is concluded that in this unique model of glomerulonephritis induced by a monoclonal antibody, recognition of Thy 1.1 epitopes as well as activation of complement including the C5-C9 membrane attack complex may play a major role in the pathogenesis of this experimental disease.

TL;DR: Both the copper-zinc and the manganese containing superoxide dismutases (SOD) have been immunolocalized in rat liver sections using protein A-gold labeling on ultrathin cryosections and the CuZnSOD was found to distribute uniformly throughout the nuclear and cytoplasmic matrix.

TL;DR: The increased microvilli, rough endoplasmic reticulum, and microfilament bundles in patients with moderate but not advanced arterial changes suggest a phase where increased endothelial metabolic function and alterations in the cytoskeleton may also contribute to heightened pulmonary vascular reactivity.

TL;DR: The results verify the localization of major basic protein to the crystalloid core of the human eosinophil granule and show that ECP and EDN reside in the granule matrix.

TL;DR: The differential distribution of the epidermal growth factor receptor to specific cell types and cellular compartments may signify adaptations that permit growth factor responsiveness in a milieu of available ligand.

TL;DR: Fibrin deposited in inflammatory reactions and solid tumors is present in forms and concentrations that either facilitate or inhibit macrophage migration; fibrin may therefore regulate macrophages participation in these and other pathologic reactions.

TL;DR: A demonstration of mast cell granule-induced endothelial proliferation suggests that the mast cell may be of importance in the process of angiogenesis.

TL;DR: There was wide variability in the reactions of macrophages and dendritic cells in different tissue and less variability among cells within individual anatomic locations.

TL;DR: Investigation of frozen tissue sections of seven cases of nodular lymphocyte predominance type of Hodgkin's disease shows differences in B cell, T cell, as well as dendritic cell population, indicating that NLPHD represents a proliferation of germinal center cells.

TL;DR: The findings suggest that local external compression causes ischemia in nerve fibers served by transperineurial vessels, with severe compression causing axonal damage, while lesser degrees of compressive injury are associated with demyelination.

TL;DR: Six squirrel monkeys immunized with native fetal bovine type II collagen in complete Freund's adjuvant developed arthritis 3 to 6 weeks later, while three monkeys became cachetic and died, the others regained weight and their arthritis spontaneously remitted with minor residual deformities in digits and larger joints.

TL;DR: The results with keratin monoclonal antibodies compare well with those obtained by others using two dimensional gel electrophoresis and they further support the idea that monoconal antibodies specific for particular keratin polypeptides will find applications in routine pathological diagnosis.

TL;DR: The inhibition of asbestos-induced cytotoxicity in a hamster tracheal epithelial cell line by superoxide dismutase, a scavenger of superoxide (O2-.), and by mannitol and dimethylthiourea, scavengers of the hydroxyl radical (OH.), implicate active oxygen species as mediators of injury by long asbestos fibers to cells of the respiratory tract.

TL;DR: It is established that human chromaffin granules contain three immunologically distinct groups of acidic proteins, which are found in other endocrine tissues but they are not always stored together.

TL;DR: The proportions of actin isoform synthesis and actin mRNA translation products in intimal SMC revert to normal values 60 days after balloon induced endothelial denudation, when the aorta is reendothelialized; however, in culture decreased alpha-actin synthesis and mRNA level persist up to the fifth passage (P5); these changes may be helpful for the understanding of SMC adaptation mechanisms during arterial development and atheromatous plaque formation.

TL;DR: Pulmonary intravascular macrophages in sheep comprise an important component of their mononuclear phagocyte system and may contribute to pulmonary inflammation and injury, it is suggested.

TL;DR: Capillary endothelial cells and fibroblasts failed to secrete an angiogenesis factor when cultured under hypoxic conditions or in high concentrations of lactate, and none of these conditions changed the expression of macrophage mitogens.

TL;DR: The thymidine labeling index (TLI) was measured in primary, invasive breast carcinomas in women by an in vitro method that achieved intense labeling of S-phase cells, indicative of a secondary phenomenon rather than a role in regulation of tumor growth.

TL;DR: The hyperlipemia that occurs in nephrosis is due to a combined defect in lipoprotein metabolism: increased hepatic synthesis of VLDL and decreased removal of TG and highly atherogenic remnants of incompletely metabolized CMs.