Matrix 

TL;DR: Studies of human and bovine adult articular chondrocytes cultured in alginate showed that the majority of the newly-synthesized aggrecan molecules are rapidly incorporated into aggregates which can be extracted from the gel in their native form.

TL;DR: It is demonstrated that the expression of BSP in bones and teeth is essentially restricted to cells directly involved in the formation of mineralizing connective tissue matrices, indicating that BSP has a specific role in biological mineralization and that it is a useful marker of bone formation.

TL;DR: The finding that the biological activity of osteogenin can be restored and delivered by a substratum with defined geometry other than the insoluble collagenous matrix may form the basis of the potential therapeutic application of bone morphogenetic proteins.

TL;DR: A 200-amino acid long motif first recognized in von Willebrand Factor (type A module) has been found in components of the extracellular matrix, hemostasis, cellular adhesion, and immune defense mechanisms.

TL;DR: The concept of a multifunctional role for OPN in bone formation and remodelling is supported, with the peak expression of OPN later in bone development, together with high expression at sites of rapid remodelling indicate that OPN deposited on the surface of mineralized connective tissues may provide a template for osteoclastic resorption.