Showing papers in "Metabolic Bone Disease and Related Research in 1981"

TL;DR: The history of diphosphonates began with studies of inorganic pyrophosphate, which was found to occur in many biological fluids and inhibited the precipitation of calcium phosphates, and inhibited crystal aggregation and dissolution.

TL;DR: Treatment with EHDP reduced the incidence and severity of lesions both at the time of stopping EH DP and up to 9 months after treatment.

TL;DR: The data indicate that EHDP can have profound effects on bone remodeling in the dog but that these effects are dose-and-time-dependent and they appear to be reversible.

TL;DR: It is suggested that an increase in the number and/or activity of osteoclasts is brought about by, 1) recruitment of new cells from a pool with a low number of nuclei (mononucleated), and 2) a fusion of these cells with preexisting osteoclast and/ or other mononucleation cells.

TL;DR: There was a significant correlation between the results using the two techniques, so that serial densitometry may be used in the estimation of calcium balance although with somewhat less precision than is obtainable with the best balance technique.

TL;DR: During hospitalization on a normal ward diet containing approximately 1200 mg calcium/day, the radiological bone lesions healed, serum PTH, 1,25-(OH) 2 D and alkaline phosphatase concentrations returned to normal, and urinary calcium excretion increased.

TL;DR: It is proposed that osteoporosis in general be considered as a perturbation of the coupling of resorption and accretion, which suggests that the overall effect is to maintain the skeleton in a state of near balance.

TL;DR: The epidemiological characteristics of Paget's disease suggest that environmental Influences are Important in its aetiology and provide data against which new hypotheses on causation must be tested.

TL;DR: Nineteen patients with involutional osteoporosis have been studied by means of combined 47 Ca kinetic and calcium balance studies and morphometric analysis of iliac crest bone biopsies taken after double tetracycline labelling, finding a close inverse relationship was found in the untreated patients between trabecular resorption surfaces (RS%) and calcium Balance.

TL;DR: In patients with chronic renal failure on long-term hemodialysis with clinical and/or radiological evidence of bone disease, calciferdiol treatment resulted in a decrease in the histological manifestations of hyperparathyroidism, and patients with inactive bone continued to show a low degree of activity even after calcifediol treatment.

TL;DR: Histologically, EHDP given at a dose of 5 mg/kg/day for 6 months appears to be an effective and safe treatment for Paget's disease of bone.

TL;DR: Osteoclasts in microphthalmic (mi/mi) mice were significantly smaller than in their heterozygous (mi/+) or normal (+/+) littermates as measured by electronmicroscopic morphometry, and the cytoplasm was not fully differentiated.

TL;DR: Results indicate that abnormal differentiation and function of the osteoblast contribute to the osteomalacic lesion present in VDRR.

TL;DR: Results of long-term intermittent EHDP treatment in 40 patients studied for 5-8 years demonstrate that a small minority of individuals experience a sustained remission after a single six-month course of therapy, while a majority require repeated courses of 5 mg/kg/day for 6 of every 12 months to maintain their initial improvement.

TL;DR: The data suggest that failure of tooth eruption in ia rats is directly related to the reduction in bone resorption and that alveolar bone Resorption is required for tooth eruption.

TL;DR: It is postulate that there may be a common genetic defect in phagocyte cells, including monocytes, neutrophils and osteoclasts, which accounts for the abnormalities of mineral metabolism and previously reported hematologic, neurologic, and infectious complications.

TL;DR: It is proposed that, in this patient, the osteopetrotic phenotype is the consequence of an abnormality in the interaction between PTH and osteoclasts that may be related to the synthesis of a physiologically "defective" PTH.

TL;DR: Treatment of Paget's disease results in a fall in urinary hydroxyproline before alkaline phosphatase, which indicates that drug treatment has a primary action to inhibit bone resorption, with a subsequent adaptive reduction in bone formation rate.

TL;DR: While correlation of x-rays and bone scans in Paget's disease have shown that neither method alone detects all lesions, it is clear that the bone scan is the more sensitive technique.

TL;DR: It is concluded that the peritrabecular granulomas of skeletal sarcoidosis may result in rapid bone turnover with diffuse osteopenia which may contribute to the abnormalities of mineral metabolism.

TL;DR: Thirty-one adult epileptic outpatients on chronic combined anticonvulsant therapy were investigated, finding that the intestinal calcium absorption in epileptic patients depends on 1,25-(OH)2D levels.

TL;DR: The bone marrow failure which appears in the malignant form of congenital osteopetrosis is at least in part due to replacement of hematopoietic precursors by osteoclasts, which suggests that a spectrum of pathogenetic mechanisms may be responsible for the development of the disease.

TL;DR: Calculated estimates of trabecular bone remodeling at the "Basic Multicellular Unit" level showed longer periods of resorption, formation and total remodeling in the hypothyroid than in the hyperthyroid patients.

TL;DR: There was an intra-individual variation which was small for the parameters of formation and particularly osteoid thickness and mineralizing rate and greater for resorption parameters.

TL;DR: From the epidemiological studies, X-Rays of 1864 patients with Paget's disease were available for examination of the skeletal distribution of the disease, and it is postulated that an environmental factor is being transported by the blood to bone.

TL;DR: It is shown in this study that macrophages participate in the process of bone resorption by eroding or removing intact bone when cultured with newborn mouse calvaria.

TL;DR: Treatment with Pi + 1,25(OH)2D stimulates the bone turnover in young patients with VDRR by inducing creation of new BMU after restoration of bone mineralization, and the extent of dual labeled bone surface was increased together with the osteoblast population, indicating that normal bone calcification requires the presence of osteoblasts.

TL;DR: It has been demonstrated that the osteoclasts in Paget's bone disease contain antigenic material which reacts positively with sera containing measles antibodies, which is strongly in favour of a viral etiology for Paget’s bone disease.

TL;DR: The persistence of embryonic characters, evidenced by high levels of alpha-fetoprotein, suggests that the developmental defect of bone is part of a more general process.

TL;DR: Long-term medical management with the use of the diphosphonates, calcitonins and mithramycin resulted in marked and rapid clinical improvements in 8 of 10 patients and suggest that drug treatment now has a place in the management of paraparesis, particularly when this is of gradual onset.