Showing papers in "Molecular Therapy - Oncolytics in 2022"

TL;DR: In this paper , the authors provide an updated review and future perspectives on features of the tumor microenvironment that represent barriers to CART cell therapy efficacy, including competition for metabolic fuels, physical barriers to infiltration, and immunosuppressive factors.

TL;DR: In this paper , a novel circular RNA, termed circRHBDD1, which augments aerobic glycolysis and restricts anti-PD-1 therapy in hepatocellular carcinoma (HCC) was discovered.

TL;DR: Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of benzene and features special physical and chemical properties, and thus has the potential to serve as a new type of pharmacophore for drug design and discovery as discussed by the authors .

TL;DR: A review of CAR T cell therapy efficacy in pancreatic cancer is provided in this article , where the major challenges and strategies to improve CAR T cells efficacy are discussed, such as arming CART cells, developing off-the-shelf allogeneic CAR Tcells, using other immune CAR cells, like natural killer cells and tumor-infiltrating lymphocytes, and combination therapy.

TL;DR: The α-Enolase (ENO1) as discussed by the authors is a glycolytic enzyme that catalyzes the conversion of 2-phospho-D-glyceric acid to phosphoenolpyruvic acid.

TL;DR: In this paper , a review of non-coding RNAs that have been associated with metastasis in GBM is presented, including miRNAs, circRNAs and lncRNAs with respect to their relevant signaling pathways involved in metastasis.

TL;DR: In this article , a review of the mechanisms of METTL1/WDR4 via m7G in tumorigenesis and corresponding detection methods is presented, mainly focusing on the mechanisms for METTL 1 and WDR4.

TL;DR: In this paper , a review of the most relevant candidates for this role among the variety of potential NK ICs is presented, and the potential relevance of this phenomenon on anti-tumor immune response is discussed.

TL;DR: In this article , the authors reported the efficacy of chimeric antigen receptor (CAR)-T cells using an anti-pan-PDPN monoclonal antibody (mAb; NZ-1)-based third-generation CAR in a xenograft mouse model.

TL;DR: In this paper , the authors summarized the deregulation and function of long non-coding RNAs in human head and neck squamous cell carcinoma (HNSCC) and discussed the potential application of lncRNAs as diagnostic/prognostic tools and therapeutic targets.

TL;DR: In this article , a semi-synthetic shark VNAR phage library and isolated anti-PD-L1 single-domain antibodies were used to evaluate the effectiveness of CAR-T therapy against breast and liver cancer.

TL;DR: In this paper , ubiquitously expressed transcript (UXT) and maternally expressed gene 3 (MEG3) were examined by qRT-PCR and Western blot and the capacity of cell proliferation, apoptosis, migration, and invasion was assessed using CCK-8, flow cytometry, and transwell assays.

TL;DR: TAM-associated macrophages exert integrated effects in all aspects of tumor progression, including tumor cell proliferation, angiogenesis, invasion, and metastasis as mentioned in this paper , and the most common combination is that of traditional chemotherapy with TAM-targeted therapy, followed by immune checkpoint inhibitors and targeted drugs.

TL;DR: In this paper , a hyaluronic acid (HA)-based nanoparticle formulation is used to deliver Let7b miRNA mimic to tumor cells and achieve cellular programming both in vitro and in vivo.

TL;DR: In this paper , the authors investigated the antitumor efficacy and TME remodeling by APTSTAT3-9R, a cell-permeable STAT3 inhibitory peptide, as a strategy to treat vemurafenib-resistant melanoma.

TL;DR: TanCAR as mentioned in this paper combines the tandem arrangement of IL13 (4MS) and EphA2 scFv (SLCFv) to improve CAR-T therapy for glioblastoma.

TL;DR: Wang et al. as mentioned in this paper investigated whether and how exosomal miR-205-5p regulated angiogenesis and nasopharyngeal carcinoma (NPC) metastasis.

TL;DR: In this paper , the authors explored the biological function of circSHKBP1 in NSCLC and found that it upregulated glycolysis through PKM2 in a HIF-1α-dependent manner in non-small cell lung cancer.

TL;DR: Lee et al. as mentioned in this paper compared second-generation and third-generation CAR-T cells with carbonic anhydrase IX (CAIX)-targeted CAR constructs in vitro and in vivo.

TL;DR: In this article , the role and mechanism of lncRNAs in the occurrence and progression of TSCC and cisplatin resistance was explored, and the results of next-generation transcriptomic sequencing revealed that lncRNA-SNHG26 was differentially expressed and was associated with TSCC cis platin resistance.

TL;DR: In this paper , a gene knockout chain reaction (GKCR) method was developed for continually generating mutagenic disruptions and used this method to disrupt the HPV18 E6 and E7 genes.

TL;DR: In this article , the authors explored the biological function of circSHKBP1 in NSCLC and found that it upregulated glycolysis through PKM2 in a HIF-1α-dependent manner in non-small cell lung cancer.

TL;DR: In this paper , an oncolytic adenovirus carrying decorin was combined with a CAR-T targeting carbonic anhydrase IX (CAIX) to perform the antitumor activity for renal cancer cells.

TL;DR: In this article , the authors successfully identified the STAT3 was the direct target of Nar through the combination strategies of connectivity map and drug affinity responsive target stability, and Nar-loaded nanoparticles could suppress phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the SH2 domain.

TL;DR: In this paper , the authors summarize the data on infection of non-cancer targets by oncolytic viruses with a special focus on tumor microenvironment and secondary lymphoid tissues.

TL;DR: In this article , the authors constructed a panel of fiber-modified recombinant adenovirus (rAd) for glioma therapy and compared their infectivity, replication, reproduction, and cytolytic efficacy.

TL;DR: In this article , a non-viral, non-plasmid-based PD-1 knockout was carried out immediately prior to the traditional 14-day TIL-based ACT rapid-expansion protocol.

TL;DR: In this paper , a safe and efficient transfection reagent for intracranial delivery of synthetic mRNA in mouse brain was evaluated, and the possible reagent-induced biological toxicity was evaluated by behavioral and blood biochemical measurements.

TL;DR: In this article , polyethylene glycol-poly(ε-caprolactone) (PEG-PCL) nanoparticles were linked to the anti-programmed death-1 monoclonal antibody nivolumab to yield αPD1-NPs for targeting TILs with PD1 overexpression using DAC.

TL;DR: In this paper , the potential roles of exosomes of different origins in ovarian cancer, cervical cancer, and endometrial cancer, which will help to determine the molecular mechanism of carcinogenesis.