Showing papers in "Pharmacological Research Communications in 1985"

TL;DR: The antioxidant properties of quercetin and its inhibitory effect on the xanthine-oxidizing enzyme are discussed with reference to hyperuricemic and ischemic states.

TL;DR: Serotonin-induced vasoconstrictor responses may play a role in the etiology of vasospasm and peripheral vascular diseases, in particular at sites of endothelial lesions, and the platelet aggregation effects of serotonin combined with its accelerated turnover may be important in the induction and maintenance of the augmented peripheral vascular resistance in arterial hypertension.

TL;DR: This finding suggests that improvement of the psoriatic condition after bathing in the Dead-Sea, may be partly attributed (in addition to ultraviolet irradiation) to the minerals' effect on the Psoriatic skin.

TL;DR: Evidence is provided that both Diclofenac and Pirprofen, two cyclooxygenase inhibitors with a potent analgesic effect both in the experimental animal and in man, induce a significant and long lasting decrease in pituitary beta-endorphin concentrations together with an increase of the hypothalamic concentrations of the peptide.

TL;DR: The increase in permeability of blood-brain barrier could be correlated to the lipid solubility of alcohols and this effect was concentration-dependent.

TL;DR: Overall results seem to indicate that ADR-ol is produced and stored in cardiac tissue during repeated ADR administration; as a consequence the cytotoxic metabolite might contribute to the cardiotoxic effect of ADR.

TL;DR: The effects of cis-diamminedichloroplatinum II on tissue and subcellular concentrations of endogenous Zn and Cu was investigated in liver and kidneys of rats injected i.p. with 5 mg/kg cis-DDP and the binding of Pt to cytosolic ligands and its effect on ZN and Cu binding was investigated.

TL;DR: Acute ethanol administration to rats fasted overnight resulted in increased lipid peroxide levels and decreased glutathione content in the liver and in this condition, hepatic glutATHione peroxidase activity remained unchanged, whereas glutathion transferase activity was decreased.

TL;DR: The impressive activity of B-HT 920 in producing SY and PE, along with its inability to evoke SB, supports the role of DA autoreceptors in the regulation of SY and sexual behaviour.

TL;DR: Results indicate that the effects of Gb on the central beta-adrenergic system might be involved in its therapeutic actions.

TL;DR: It is concluded that histamine increases the permeability of BBB by affecting H2-receptors linked to adenylate cyclase by affecting histaminergic mechanisms in the regulation of blood-brain barrier.

TL;DR: The results suggest that a noradrenergic alpha-adrenoceptor system maintains penile flaccidity in the dog, and that penile erection may result from the activation of inhibitory beta2- adrenergic, muscarinic and/or peptidergic systems.

TL;DR: The concurrent increase of serum CPN level during induced inflammatory conditions suggest the involvement of serumCPN as one of the body's inbuilt defensive mechanism against noxious responses or inflammation.

TL;DR: Central and peripheral alpha 2 stimulation by clonidine was able to completely suppress cortisol release during surgery.

TL;DR: It is found that social isolation induced a decrease in the number of opiate receptors in rat frontal cortex, striatum, hippocampus and periaqueductal grey matter, and this decrease was most pronounced in isolated aggressive rats.

TL;DR: These experiments showed a spontaneous conjugation of the mercury compounds with GSH, explaining the parabolic inhibition observed in the kinetic studies with G SH as the variable substrate.

TL;DR: It was shown that pCT and hCT reduced significantly meal size only for 1-2 hours when serum Ca++ levels were at their lowest levels for these peptides.

TL;DR: It is demonstrated that the concentration of progesterone receptors in the brain of adult, ovariectomized, female rats is maximal in frontal cortex and midbrain and lowest in the cerebellum.

TL;DR: It is suggested that high doses of valproate may increase brain GABA by interfering with intermediate metabolism, possibly at the level of medium chain acyl CoA.

TL;DR: The glutathione peroxidase activity in the psoriatic patients increased significantly during their four-week stay in Ein-Bokek, and a possible role of selenium in psoriasis is suggested.

TL;DR: It was found that the electrophilic agents, diethylmaleate (DEM) and ethacrynic acid (ETHAC) that react with SH groups, determine an in vitro decrease in plasma SH group concentration and a Kr increase.

TL;DR: The mechanism of action of PCP and KT is discussed in connexion with the similarities of the effects of this drugs in respect to sigma opiate agonists and pentobarbital and seems not to depend on the neurotransmitter system related to the reported drugs.

TL;DR: Besides the well documented effect of P on cholinergic neurons, P seems to exert its biological and behavioural effects through activation of catecholaminergic mechanisms.

TL;DR: It is concluded that olive oil favours enteral absorption of heparin by increasing bile function by influencing plasma clearing activity and inhibition of blood coagulation.

TL;DR: In rat the kinetics of flunitrazepam (FNZ) was evaluated by a radioreceptor assay (RRA) after i.v. administration and after oral administration of 1 and 3 mg/kg and the peak concentrations of FNZ-equivalent in brain, kidneys and heart are higher than the corresponding peak concentration in plasma.

TL;DR: It is concluded that lefetamine is an opioid agonist that competes with all these opiates with an affinity 50 times lower than that of morphine.

TL;DR: This radioiodinated GM1 derivative might be useful for the study of ganglioside GM1 function in vivo.

TL;DR: In this paper, various histamine H2 receptor antagonists were tested for their possible effects on intestinal motility of the dog both "in vivo" and "in vitro" and they were found to behave quite differently from one another: ranitidine exerted a small atropine-sensitive stimulatory effect by itself and strongly potentiated the stimulatory action of compounds which interfere with the cholinergic system thus confirming its cholinomimetic direct or indirect activities.

TL;DR: Findings indicate that DA makes the rat seminal vesicle contract mostly by means of an indirect mechanism, binding presynaptic DA-receptors and, in part, presYNaptic alpha-adrenoceptors as well.