Showing papers in "Prostaglandins and Medicine in 1979"

TL;DR: The low peroxide levels expected in vivo would most probably cause the (n-3) type of fatty acid to be a general inhibitor of prostaglandin formation, through both reversible and irreversible actions at the enzyme site.

TL;DR: In this article, the plasma levels of thromboxane B2 (TxB2) were determined by radioimmunoassay in 6 consecutive patients with Prinzmetal's angina and in 9 healthy volunteers.

TL;DR: The present findings suggest that moderate dietary supplements of fish oil may be beneficial in the prophylactic treatment of ischemic cerebral vascular disease.

TL;DR: Vitamin C caused a dose dependent and highly significant enhancement of conversion of 14C-dihomogammalinolenic acid to prostaglandin E1 and to thromboxane B1 by human platelets, and can account for a number of the known actions of vitamin C including its effect on the immune system.

TL;DR: The metabolic profiles and the levels of each metabolite obtained by both procedures were comparable and the profile of arachidonic biosynthesis was unique to each cell.

TL;DR: Recent observations coupled to the aforementioned findings provide strong evidence in support of a physiological role for PGs in the hypothalamic control of gonadotropin release.

TL;DR: Levels of malondialdehyde, indicating the sum of lipid peroxidation dependent and independent of cyclo-oxygenase activity, were measured in rheumatoid arthritis patients and correlated with more active RA.

TL;DR: Immunoassays for thromboxane B2, 6-keto-prostaglandin Fla, and 5,6-dihydroprostagslandin I 2 were used to identify their respective homologous ligands that were separated by normal phase and reversed phase high pressure liquid chromatography.

TL;DR: It is suggested that vitamin E acts to inhibit platelet internal contraction and secretion by preventing efflux of calcium from the dense tubular system.

TL;DR: It was concluded that the observed antiplatelet activity of onion relates to the presence of a non-polar, heat stable inhibitor of thromboxane synthesis, which appears to be the first demonstration of this type of inhibitor present in significant quantities in a common foodstuff.

TL;DR: The irreversible effect of acetylsalicylic acid on platelet cyclooxygenase activity is inhibited by salicylate and by sulfinpyrazone, and it is possible that persistant elevation of plasma saliylate may interfere with the efficacy of subsequent doses of aspirin.

TL;DR: It is suggested that the altered tissue concentrations of prostaglandins in pre-eclamptics are due to the effects of gestational age and oestrogens and may or may not be involved in the pathogenesis of pre- eclampsia.

TL;DR: The synthesis of thromboxane A2 by blood platelets in the presence of ethanol and in platelets from animals dosed chronically with ethanol has been examined and measurement of total products indicated that neither fatty acid cyclooxygenase nor platelet lip oxygengenase was influenced by blood ethanol levels generally associated with intoxication.

TL;DR: The results suggest that fluid secretion of the rabbit lacrimal gland in response to PGE1 may be caused by excitation of the sympathetic ganglia and/or by direct action on beta-receptors in the acinar cells.

TL;DR: Three groups of neonatal piglets were anesthetised and base-line hemodynamic measurements were made, then subjected to hypoxia and hypercapnea to raise pulmonary vascular resistance (PVR) and further hemodynamic Measurements were made.

TL;DR: Treatment of neuroleptic-resistant schizophrenics with essential fatty acids and penicillin in an attempt to increase synthesis of 1 series prostaglandins had a therapeutic effect in six severely ill patients.

TL;DR: The data suggest that dietary content of sodium may alter prostaglandin E excretion, but that acute changes in PGE excretion during saline administration reflect water balance rather than sodium load.

TL;DR: The PGI2 can exert an arrhythmogenic effect following coronary artery occlusion and that this effect occurs in a biphasic manner i.e., the increase in arrhythmia observed at 27 did not occur at 270 but occurred again at the 10 fold higher dose (2700 pmole).

TL;DR: During kaolin-inducedgranuloma pouch inflammation in the rat the concentration of malondialdehyde (MDA) in the exudate steadily increased and this increase was correlated with the increase in granuloma weight, and there was a complete lack of correlation between the concentrations of MDA and prostaglandin (PG)-like material in the inflammatory exudates.

TL;DR: The data suggest a multifactorial explanation for abnormalities of prostaglandin metabolism in human breast cancer and a weak but statistically significant correlation between prostaglandsin synthetase activity and tissue prostag landin E2 levels of individual specimens.

TL;DR: The growth of the R3230AC mammary carcinoma was studied in female Fisher 344 rats that were treated with diazepam and tumour size was significantly increased in the group receiving 250 micrograms but was below the levels observed in the saline treated controls.

TL;DR: It is suggested that the instability of PGI2 in aqueous solution is at least partially responsible for its relative inability to maintain elevated levels of cyclic AMP and concomitant suppression of mitogenesis.

TL;DR: The production of large amounts of prostaglandins by bones in response to infection may be the cause of the rapid bone resorption and sequester formation observed in osteomyelitis.

TL;DR: PTA2 prevented the accumulation of thromboxane B2, the lysosomal protease, cathepsin D, and the cardiotoxic peptide MDF in the circulating blood.

TL;DR: The results suggest that indomethacin may act to inhibit the prostaglandin endoperoxide synthetase enzyme by complexing Fe++ in the enzyme by forming a one to one complex forming between indometHacin and Fe++.

TL;DR: Ticlopidine, known to inhibit the primary wave of ADP-induced platelet aggregation and to increase the bleeding time, can modify platelet prostaglandin metabolism and the basal level of platelet PGE1 is enhanced by the drug.

TL;DR: Levels of PGE 2 , PGF 2α , PGI 2 (measured as 6-keto-PGF 1α ), and thromboxane B 2 were determined in rat inflammatory exudates induced 1, 3, and 7 days after carrageenin injection into air-pouch granuloma.

TL;DR: The three test systems used for evaluation have demonstrated that suitable modifications of the ω-side chain of prostacyclin result in potent vasodilator and plateletantiaggregating agents.

TL;DR: The presence of a relatively high prostaglandin cyclooxygenate activity in cultured neuroblastoma cells is of particular interest in that these cells may be useful model systems for studies of some aspects of neuronal prostaglandsin synthesis.

TL;DR: Observations indicate that PGI2 can influence hemostasis by mechanisms independent of platelet aggregation, and this effect was associated with a decreased production of P GI2-like material by the vessel wall and a reduction in the volume of fluid lost from the standard puncture wound in the jugular vein.