Showing papers in "Seminars in Oncology in 1985"

TL;DR: This initial attempt at pharmacologic direction of chemotherapy was successful in elevating minimum ara-CTP levels but did not produce an increase in response rate, probably because the total duration of ara -CTP exposure was decreased when the dose intervals were shortened.

TL;DR: Pharmacokinetic theory predicts that a large and potentially exploitable concentration difference occurs between the peritoneal cavity and the plasma after many anticancer drugs are administered intraperitoneally in large volume.

TL;DR: Different platinum chemotherapeutic agents, pharmacodynamics, and pharmacokinetics of intraperitoneal administration, and rescue agents other than sodium thiosulfate are presently being investigated by The Netherlands Cancer Institute.

TL;DR: Patients with non-small-cell lung cancer--especially those who have a good performance status and thus are more likely to respond--should be considered for participation in clinical studies in which the control regimens are associated with moderate response rates.

TL;DR: The intestinal type of gastric cancer is probably related to diet, characterized by low fat and animal protein intake, high ingestion of grains and tubercular roots, high salt intake, and low intake of fresh fruits and fresh vegetables, and the management of these lesions needs further clinical research.

TL;DR: Dose, schedule, route, and preparation have yet to be established for maximum efficacy, but progress has been made toward defining factors predicting response to treatment and mechanisms of interferon action.

TL;DR: The technical experience accumulated with either the Tenckhoff catheter or the Port-A-Cath in 288 patients treated at five institutions showed a low incidence of catheter-related peritonitis, skin infection, and bowel perforation following surgical implantation.

TL;DR: Significant intersubject and intrasubject variation was observed in intravenous and oral pharmacokinetics and oral bioavailability in cancer patients, which could be related to intrapatient and interpatient differences in nonrenal clearance and the inherent patient and disease status problems in evaluating the Pharmacokinetics of anticancer drugs.

TL;DR: The cisplatin dose is an important factor in achieving improved results in the treatment of ovarian cancer, and the preliminary results indicate that intensive treatment with high-dose cis platin and cyclophosphamide of short duration can produce a high complete remission rate.

TL;DR: Intraperitoneal 5-FU may be recommended for investigation in patients with perforated colon cancer, peritoneal implants, or as one part of a multimodality treatment protocol for colorectal cancer.

TL;DR: To accomplish this goal successfully, megestrol acetate was combined with DES or estradiol to suppress testicular function to castration levels and to block residual adrenal androgens at the cell level.

TL;DR: Suggestions for effective adjuvant therapies, based on the realization that most gastric cancer has become a systemic disease by the time of diagnosis, are apparent from the clinical trials to date.

TL;DR: Mitomycin-C is an effective antitumor agent in breast cancer and should be carefully incorporated in the therapeutic strategy of this disease.

TL;DR: Recombinant interferons have achieved a place in the developmental armamentarium of medical oncology for melanoma--and phase III trials to compare the relative effects of decarbazine or semustine and interferon alpha are under way.

TL;DR: The demonstration that some of the resistant cell lines have a decreased accumulation of doxorubicin and that resistance in these lines can be reversed by a calcium channel blocker has led to a clinical trial of verapamil plus doxorbicin in refractory ovarian cancer patients.

TL;DR: It appears that further therapy after remission induction has not yet proven beneficial, and selected areas of therapeutic investigation are reviewed, including non-cross-resistant chemotherapy, dose intensification, manipulation of the duration of therapy, combined modality therapy, and salvage chemotherapy.

TL;DR: Although the growth of SCLC cells in a clonogenic assay may be of value in chemotherapy selection, the established cell lines provide a model for studying mechanisms of drug and radiation sensitivity; and drug metabolism, and the establishment of cell lines has clearly indicated the considerable heterogeneity that exists in SclC.