W
William Plunkett
Researcher at University of Texas MD Anderson Cancer Center
Publications - 362
Citations - 30481
William Plunkett is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Fludarabine & Leukemia. The author has an hindex of 87, co-authored 358 publications receiving 28995 citations.
Papers
More filters
Journal ArticleDOI
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
Journal ArticleDOI
Early Results of a Chemoimmunotherapy Regimen of Fludarabine, Cyclophosphamide, and Rituximab As Initial Therapy for Chronic Lymphocytic Leukemia
Michael J. Keating,Susan O'Brien,Maher Albitar,Susan Lerner,William Plunkett,Francis J. Giles,Michael Andreeff,Jorge E. Cortes,Stefan Faderl,Deborah A. Thomas,Charles Koller,William G. Wierda,Michelle A. Detry,Alice Lynn,Hagop M. Kantarjian +14 more
TL;DR: FCR produced a high CR rate in previously untreated CLL, and most patients had no detectable disease on flow cytometry at the end of therapy.
Journal Article
Action of 2',2'-difluorodeoxycytidine on DNA synthesis.
TL;DR: Qualitative and quantitative differences in the molecular actions of dFdC and arabinosylcytosine on DNA metabolism are demonstrated, but are consistent with an important role for such incorporation in the toxicity of d FdC.
Journal ArticleDOI
Superoxide dismutase as a target for the selective killing of cancer cells
TL;DR: It is reported that certain oestrogen derivatives selectively kill human leukaemia cells but not normal lymphocytes, and that mechanism-based combinations of SOD inhibitors with free-radical-producing agents may have clinical applications.
Journal Article
Gemcitabine : metabolism, mechanisms of action, and self-potentiation
TL;DR: The unique actions that gemcitabine metabolites exert on cellular regulatory processes serve to enhance the overall inhibitory activities on cell growth and is evidenced in very few other anticancer drugs.