Showing papers in "Survey of Ophthalmology in 2000"

TL;DR: The concept that AMD can be attributed to cumulative oxidative stress is enticing, but remains unproven, and the effect of nutritional antioxidant supplements on the onset and natural course of age-related macular disease is currently being evaluated.

TL;DR: The "normal" central corneal thickness (CCT) value in human corneas was determined based on reported literature values for within-study average CCT values, and the reported impact of physiological variables, contact lens wear, pharmaceuticals, ocular disease, and ophthalmic surgery on CCT was assessed.

TL;DR: The focus of this paper is to review the basic properties of ICG and to show how some clinical features related to basic properties also depend on the instrumentation used to perform ICG angiography.

TL;DR: Stem cells have certain unique characteristics, which include longevity, high capacity of self-renewal with a long cell cycle time and a short S-phase duration, increased potential for error-free proliferation, and poor differentiation.

TL;DR: Selective occlusion of choroidal neovasculature by this therapy causes minimal damage to the neurosensory retina and, therefore, does not induce loss of visual acuity, which allows verteporfin therapy to be used in the large proportion of patients who are not eligible for treatment by laser photocoagulation.

TL;DR: The clinical course of significant retinal laser injuries is characterized by sudden loss of vision, often followed by marked improvement over a few weeks, and occasionally severe late complications.

TL;DR: The immature visual system in infants born preterm is vulnerable to adverse events during the perinatal period and periventricular leukomalacia affecting the optic radiation has now become the principal cause of visual impairment and dysfunction in children born prematurely.

TL;DR: Current developments in management include newer classes of drugs, surgical procedures, such as trabeculectomy with mitomycin-C, implantation of glaucoma drainage devices, and cyclodestructive procedures with Nd: YAG and diode lasers.

TL;DR: The mechanisms of normal wound healing are discussed, describing the animal and fetal wound healing models used to provide further insight into normal wound repair and the rationale behind the pharmacological agents currently used to modulate the wound healing response.

TL;DR: It is concluded that emerging refractive surgery technologies may provide substantial increases in visual performance as well as theoretical limits on foveal vision.

TL;DR: Brinzolamide is a new topically active CAI that is safe and efficacious for reducing intraocular pressure and offers the convenience of topical dose administration and greater freedom from side effects related to the inhibition of CA seen with the systemic administration of CAIs.

TL;DR: Electrophysiological research on acquired retinal disorders, both common and rare, is reviewed and ERG measurements can reveal vitamin A deficiency and are altered in cases with a mutation in the gene for the retinol binding protein in which other organs are not affected.

TL;DR: Two independent, prospective, multicenter, double-masked, parallel group trials were conducted to compare the ocular comfort of brinzolamide 1.0% in patients with primary open-angle glaucoma or ocular hypertension and found that it was significantly more comfortable than dorZolamide 2.0%, which was both statistically significant and clinically relevant.

TL;DR: Clinical and histopathological findings of two patients with iris infiltration by primary intraocular lymphoma are studied and the findings of 163 cases reported in the literature are reviewed.

TL;DR: IOP reduction from baseline, including peak and trough times, was the primary end point, and brinzolamide was significantly more comfortable than dorZolamide upon instillation, and equaled each other in IOP-lowering efficacy.

TL;DR: This paper will provide the clinician with one method of clinically organizing nystagmus, describe the patients who may benefit from optical treatments, and discuss the methodology used in their implementation.

TL;DR: When administered twice daily, brinzolamide 1% was well tolerated by patients with primary open-angle glaucoma or ocular hypertension, and the incidence of adverse events was dose-dependent, and those related to therapy were usually mild and resolved without treatment.

TL;DR: Of 173 patients with histopathologically proven retinoblastoma seen in the institute, three were adults; all the patients had endophytic tumors with vitreous seeds and all three patients ultimately required enucleation.

TL;DR: The imaging anatomy of the cranio-orbital junction and adjacent subarachnoid spaces is described and high-resolution magnetic resonance images of normal subjects are presented, and the results are compared with findings reported in the literature.

TL;DR: This prospective, multicenter, double-masked, placebo-controlled study evaluated the safety and efficacy of brinzolamide 1% ophthalmic suspension (Azopt) when used adjunctively with open-label timolol maleate 0.5% (Timoptic) to produce clinically and statistically significant additional intraocular pressure reductions.

TL;DR: It is concluded that despite the theoretical possibility of a causal association of uveal melanoma and NF1, it may still be regarded as coincidental in the absence of any strong evidence to the contrary.

TL;DR: This review provides a practical guide to the examination and interpretation of eye movements in the child and includes recent literature on eye movement disorders of childhood.

TL;DR: Line or grids to document metamorphopsia have appeared in ophthalmology textbooks for more than 100 years, but testing for macular degeneration did not become routine until the dissemination of Amsler's grids in the middle of the 20th century.

TL;DR: Topical ocular CAI treatment for 1 week with either brinzolamide or dorZolamide significantly reduced IOP and significantly increased ONH blood flow in tranquilized Dutch-belted rabbits, while eliciting minimal systemic acid-base balance disturbances.

TL;DR: A 44-year-old woman presented with a painful abducens nerve palsy in the left eye and Examination revealed a white, quiet eye and an orbital bruit without proptosis, confirming a posterior draining carotid-cavernous fistula.

TL;DR: A 41-year-old man presented with acute bilateral loss of vision upon awakening after elective surgery and it was determined that he had suffered bilateral posterior ischemic optic neuropathies secondary to hypotension while under general anesthesia.

TL;DR: A case of leiomyoma of the ciliary body presenting as a fleshy mass in the anterior chamber, removed by partial lamellar sclerouvectomy was treated.