Journal ArticleDOI
Progress in 1,3-dipolar cycloadditions in the recent decade: an update to strategic development towards the arsenal of organic synthesis
About:
This article is published in Tetrahedron.The article was published on 2016-03-31. It has received 147 citations till now. The article focuses on the topics: Organic synthesis.read more
Citations
More filters
Journal ArticleDOI
Advances of azide-alkyne cycloaddition-click chemistry over the recent decade
TL;DR: This review describes the general features and applications of CuAAC in organic synthesis (CuAAC-OS), highlighting the suitability of this kind of reaction for peptides, nucleotides, small molecules, supramolecular structures, and polymers among others.
Journal ArticleDOI
Consecutive multicomponent reactions for the synthesis of complex molecules.
Sanjun Zhi,Xiaoming Ma,Wei Zhang +2 more
TL;DR: This review article highlights the Ugi, Groebke-Blackburn-Bienaymé, Biginelli, Huisgen, Petasis, Gewald, and Asinger reaction-initiated consecutive MCRs.
Journal ArticleDOI
Conjugated Ynones in Organic Synthesis.
TL;DR: This review article will consider the preparation and application of ynones in synthetic organic chemistry, focused on conjugate additions with boron-, carbon-, nitrogen-, oxygen-, and other heteroatom-containing nucleophiles, as well as radicals.
Journal ArticleDOI
Redox-Activated Amines in C(sp3)–C(sp) and C(sp3)–C(sp2) Bond Formation Enabled by Metal-Free Photoredox Catalysis
TL;DR: This work presents a metal-free photoredox strategy for the formation of C(sp3)–C(sp) and C( sp3)-C( sp2) bonds from redox-activated primary amine derivatives, suitable for synthesis of (E)-alkenes from vinyl phenyl sulfones.
Journal ArticleDOI
Recent advances in the enantioselective 1,3-dipolar cycloaddition of azomethine ylides and dipolarophiles
TL;DR: In this article, a detailed overview of the latest developments in this area since 2014 and highlight the recent improvements in the structural scope of dipolarophiles, azomethine ylide precursors, and chiral ligands.
References
More filters
Journal ArticleDOI
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.
Journal ArticleDOI
Click Chemistry: Diverse Chemical Function from a Few Good Reactions.
TL;DR: In this paper, a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries through heteroatom links (C-X-C), an approach called click chemistry is defined, enabled, and constrained by a handful of nearly perfect "springloaded" reactions.
Journal ArticleDOI
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.
TL;DR: A novel regiospecific copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes to azides on solid-phase is reported, and the X-ray structure of 2-azido-2-methylpropanoic acid has been solved, to yield structural information on the 1, 3-dipoles entering the reaction.
Journal ArticleDOI
1,3-Dipolar Cycloadditions. Past and Future†
TL;DR: In contrast to the very large number of special methods applicable to syntheses in the heterocyclic series, relatively few general methods are available as discussed by the authors, and the 1,3-dipolar addition offers a remarkably wide range of utility in the synthesis of five-membered heterocycles.
Journal ArticleDOI
The growing applications of click chemistry
John E. Moses,Adam D. Moorhouse +1 more
TL;DR: This tutorial review examines the copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes, which has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.
Related Papers (5)
Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions
Takuya Hashimoto,Keiji Maruoka +1 more
Intramolecular dipolar cycloaddition reactions of azomethine ylides.
Iain Coldham,Richard Hufton +1 more