Showing papers in "The Breast in 2003"

TL;DR: A new histological grading system, which assesses the histological response to primary chemotherapy, can predict overall survival and disease-free interval in patients with large and locally advanced breast cancers treated with such therapy.

TL;DR: Breast tumors with high levels of AIB1 and HER-2 may be resistant to tamoxifen because of an increase in its estrogen agonist activity.

TL;DR: The data demonstrate that breast cancers arising in young women have a significantly different biopathological profile from those in older patients, with a predominance of unfavourable prognostic parameters.

TL;DR: A new technique of intraoperative radiotherapy of a breast quadrant after the removal of the primary carcinoma (ELIOT) is developed, using a mobile linear accelerator with a robotic arm to deliver electron beams able to produce energies from 3 to 9 MeV.

TL;DR: This study has correlated pathology features of cancers with the frequency of HER2 overexpression assessed by immunohistochemistry using HercepTest (Dako) and would advocate consideration of a triage approach to HER2 testing.

TL;DR: A female-to-male trans-sexual, aged 33, who developed breast cancer 10 years after cosmetic bilateral subcutaneous mastectomy and nipple reimplantation is described.

TL;DR: These cases demonstrate the difficulty in clinical diagnosis of granulomatous mastitis and emphasizes that although there may be clues from the history, clinical awareness that this condition can mimic breast cancer in all aspects of the triple assessment process should arouse suspicion.

TL;DR: Neither clinical advantages or disadvantages of the ultrasound dissection technique were found and no differences in the outcome of surgery were found.

TL;DR: More care should be taken in managing patients with complex FAs and FAs with hyperplasia with or without atypia, and core biopsy may be a better option in diagnosis of FAs.

TL;DR: Current dietary advice should be to avoid obesity, limit alcohol intake, and maintain a varied diet to reduce the risk of breast cancer and improve the chances of survival.

TL;DR: Patients with BBC have a higher rate of distant metastasis and a worse DSS than those with UBC, and BCT is not contraindicated in BBC.

TL;DR: The risk of developing a contralateral breast cancer more than 6 months after the initial breast cancer was independent of surgical or radiation therapy, time since diagnosis, age at diagnosis, histology, race, marital status, or anatomic location of the cancer within the breast.

TL;DR: Twelve cases of neuroendocrine-differentiated carcinoma of the breast displaying common and uncommon histological features are reported, indicating that this category is a rare and distinct category with different histological subtypes.

TL;DR: The use of the USC/Van Nuys Prognostic Index, a clinical algorithm designed to assist physicians in selection of appropriate treatments, is reviewed, and the impact of margin status as a sole predictor of local recurrence is examined.

TL;DR: It is proposed that women who develop breast cancer despite an early first delivery represent a selected group of patients with particularly aggressive disease, and there is no evidence that pregnancy after breast cancer treatment has a negative influence on prognosis.

TL;DR: The study revealed that there is a clear need for information to be written specifically for this patient group and that emotional support for high-risk women offered BPM should be provided.

TL;DR: The authors believe that total mastectomy for infiltrating lobular carcinoma is a safer option to control local disease, especially in younger patients and those with high-grade tumours and overall survival is not affected by the type of surgical treatment.

TL;DR: At service delivery level, CL is an accurate alternative to HL with better logistics and favourable costs and has the potential to improve the cost effectiveness of breast screening programmes.

TL;DR: Localized 1H-MRS using breast imaging coil can provide excellent sensitivity and spectral resolution to detect choline compounds present in reasonably small voxel of breast cancer lesion, and would be useful for differential diagnosis between malignant and benign breast diseases when combined use with MR imaging.

TL;DR: Zoledronic acid is the first bisphosphonate shown to have a direct clinical benefit in the treatment of osteoblastic bone metastases, reducing the number and rate of skeletal events in prostate cancer patients with metastatic bone disease.

TL;DR: It was recorded that screening had a beneficial effect even in women whose cancer had already spread into the axillary lymph nodes, and the effect of population-based mammography screening on survival was far better in the "screened" group than in the 'clinical' group.

TL;DR: MRI was more sensitive than FDG-PET in disclosing malignant breast tumours and was also more accurate thanFDG- PET in the assessment of multifocal disease and of the two imaging methods capability of depicting eventual multifocal Disease.

TL;DR: Despite the widespread use of sentinel lymph node biopsy (SLNBx) in the surgical management of breast cancer patients, several areas remain controversial, including learning curves and validation studies, and the value of scintigraphy, which is being addressed in clinical trials.

TL;DR: The data show that hsp27, pS2 and stromal CD expression may reflect tumor differentiation and the functional status of ER in breast cancer, but stronal CD and tumor MT expression were the only factors found that may be of limited prognostic value.

TL;DR: Anastrozole demonstrated efficacy at least equivalent to that of tamoxifen in first-line randomized, phase III clinical trials in postmenopausal women with hormone receptor-positive or unknown metastatic breast cancer, whereas letrozoles demonstrated superiority.

TL;DR: Studies in multiple myeloma and breast cancer models have shed further light on the possible mechanisms underlying the in vivo anti-tumor effects of zoledronic acid, leading to the development of novel strategies to target specific molecular pathways involved in osteoclast maturation and activity, tumor cell metastasis, and tumor growth and survival.

TL;DR: Serum VEGF and IGF-I and nitrate+nitrite levels were higher in patients with metastatic disease than in those with nonmetastatic disease or in controls, and NO may involve an angiogenic process that is stimulated by VEGf in breast carcinoma.

TL;DR: The ongoing IBIS-II trial of chemoprevention for high risk postmenopausal women is presented as one approach to managing high risk women.

TL;DR: Low SES women, particularly in urban areas, should be specifically targeted to increase their likelihood of re-attendance for breast cancer screening within an organized program.

TL;DR: The aim of this paper is to briefly outline these paraneoplastic neurological syndromes and consider their relation to breast carcinoma.