Showing papers in "Trends in Cell Biology in 2022"

TL;DR: In this paper , a review highlights how amoeboid behaviour is not merely a migration mode but rather a cellular state within the epithelial-to-mesenchymal transition (EMT) spectra.

TL;DR: In this article , the authors review recent advances in the understanding of Arp2/3 complex regulation, including high-resolution cryoelectron microscopy (cryo-EM) structures that illuminate the mechanisms of ARP 2/3 activation and branch formation, and novel cellular pathways of branch formation and debranching.

TL;DR: In this article , a review emphasizes the urgent need to investigate senescence heterogeneity and discuss how this could be accomplished by using advanced technologies and sequencing datasets, such as single-cell RNAseq and single-nucleus RNA-seq.

TL;DR: In this paper , the authors proposed that long noncoding RNAs (lncRNAs) are able to drive aberrant liquid-liquid phase separation (LLPS) in cancer in response to stressors.

TL;DR: Tau alone or in the presence of RNA has a high propensity to undergo liquid-liquid phase separation (LLPS), forming liquid droplets as mentioned in this paper , which may contribute to normal biological functions of the protein as well as to tau pathology in neurodegenerative diseases.

TL;DR: In this paper , the authors discuss recent advances in understanding the diversity of non-canonical ORFs and their roles, as well as detail biologically important examples within the context of the mammalian genome.

TL;DR: In this paper , the authors proposed a mechano-based therapeutic target to ameliorate the progression of fibrosis in multiple organs (e.g., liver, lung, and heart).

TL;DR: In this article , the authors provide new perspectives on this crucial but understudied metabolic pathway in cancer, based on recent findings, and provide new insights on the contribution of transsulfuration to cancer metabolism.

TL;DR: In this article , the authors provide new insights into the break-induced replication (BIR), MiDAS, and ALT pathways and their shared similarities, including the activation of alternative lengthening of telomeres (ALT).

TL;DR: In this article , the tumor microenvironment is viewed as a cohesive tissue constituting a novel pathological organ, arising from the coordinated differentiation of its constituent cell types, a process termed tumor-associated neodifferentiation (TAND).

TL;DR: The potential impact of unrepaired SSBs is illustrated by the existence of genetic diseases in which proteins involved in SSB repair (SSBR) are mutated, and which are typified by hereditary neurodevelopmental and/or neurodegenerative disease as mentioned in this paper .

TL;DR: A recent review as mentioned in this paper highlights recent conceptual and experimental advances that should provide exciting opportunities for future research into cell-3D matrix interactions, which can potentially lead to targeted therapeutic interventions, and provides new insights and potential opportunities for intervention in diseases and disorders.

TL;DR: In this article , the authors discuss emerging evidence for a non-canonical mTORC1 signaling pathway that controls the function of microphthalmia/transcription factor E (MiT-TFE) transcription factors, key regulators of cell metabolism.

TL;DR: The basic body plan of the mammalian embryo is established through gastrulation, a pivotal early postimplantation event during which the three major germ layers (endoderm, ectoderm and mesoderm) are specified with cellular and spatial diversity as mentioned in this paper .

TL;DR: In this paper , a repeating β-groove (RBG) domain was proposed to unify all the RBG domain-containing lipid transfer proteins as members of an RBG protein superfamily.

TL;DR: In this paper , the authors review and discuss the recent advances in the study of the diverse roles of peroxisomes during viral infections, from animal to plant viruses, and from basic to translational perspectives.

TL;DR: In this paper , the key role of proximal tubule metabolism in kidney disease development was investigated and it was shown that mitochondrial defects in renal tubules contribute to epithelial atrophy, inflammation, or cell death.

TL;DR: In this paper , the authors review theoretical and experimental advances from the past few years, focussing on the regulation and role of potential tissue rigidity transitions in different biological processes, including embryo development, tissue homeostasis, wound healing, and disease progression.

TL;DR: In this article , the mutual regulation between cellular metabolism and gene expression in a feedback mechanism constitutes a unique feature of tumor cells and provides specific molecular and functional targets for cancer treatment, which is a major driving force of enhanced aerobic glycolysis in tumor cells.

TL;DR: In this article , the authors explore potential valuable targets based on present studies of m7G-related cancer to improve disease therapy and prognoses, which is a significant RNA modification occurring during epigenetic regulation.

TL;DR: In this article , a comprehensive overview of PAD expression at the RNA and protein levels, and a list of annotated substrates per PAD isozyme are provided, as well as the effects of protein deimination.

TL;DR: In this paper , the authors review the most popular single nucleus segmentation tools and provide an interactive method browser to select the most appropriate solution, and provide a benchmarking platform to compare them.

TL;DR: The 21-member connexin gene family exhibits distinct tissue expression patterns that can cause a diverse array of over 30 inherited con-nexin-linked diseases ranging from deafness to skin defects and blindness as discussed by the authors .

TL;DR: In eukaryotes, over 600 E3 ubiquitin ligases form part of the UPS which detects structural characteristics in its target proteins and selectively induces their degradation as discussed by the authors .

TL;DR: In this article , the extracellular matrix (ECM) modifications support metastasis in four frequent metastatic sites (the lung, liver, bone, and brain) and discuss ways in which these modifications are shared between metastatic organs as well as features specific to each location.

TL;DR: In this article , a review of the genetic and epigenetic changes associated with normal aging and the mechanisms responsible for these changes is presented, highlighting the possible impacts of the normal aging process on malignant transformation.

TL;DR: In this paper , the authors discuss the multifaceted notion of cancer cell plasticity associated with metastatic colonization and discuss the major obstacle to efficacious anti-cancer therapies.

TL;DR: In this paper , the authors overview the current knowledge on the mechanisms and physiological roles of these 'nucleophagy' pathways and discuss their possible interplays and remaining issues, as well as discuss their potential interplay.

TL;DR: For most genes, mRNA transcript abundance scales with cell size to ensure a constant concentration as discussed by the authors , and there is also considerable evidence for feedback mechanisms that kinetically couple the rates of mRNA synthesis, nuclear export, and degradation to allow cells to compensate for changes in one by adjusting the others.

TL;DR: In this paper , the extracellular matrix (ECM) remodeling in adipose tissues (ATs) was studied and how it affects obesity-related cancer progression, and the authors focused on the effect of ECM remodeling on the physical shape and biological function of AT.