1-(6-chloronicotinyl)-2-nitroimino-imidazolidines and related compounds as potential new insecticides

TL;DR: The complex structure–activity relationships associated with biologically active molecules mean that the introduction of fluorine can lead to either an increase or a decrease in the efficacy of a compound depending on its changed mode of action, physicochemical properties, target interaction, or metabolic susceptibility and transformation.

...read moreread less

Journal ArticleDOI

Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors

Motohiro Tomizawa, +1 more

- 28 Nov 2003 -

Annual Review of Entomology

TL;DR: Knowledge reviewed here of the functional architecture and molecular aspects of the insect and mammalian nAChRs and their neonicotinoid-binding site lays the foundation for continued development and use of this new class of safe and effective insecticides.

...read moreread less

Journal ArticleDOI

Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors

Kazuhiko Matsuda, +5 more

- 01 Nov 2001 -

Trends in Pharmacological Sciences

TL;DR: Electrostatic interactions of the nitroimine group and bridgehead nitrogen in imidacloprid with particular nAChR amino acid residues are likely to have key roles in determining the selective toxicity of imidcloprid.

...read moreread less

Journal ArticleDOI

Neonicotinoids—from zero to hero in insecticide chemistry

Peter Jeschke, +1 more

- 01 Nov 2008 -

Pest Management Science

TL;DR: This review comprehensively describes particularly the origin, structure and bonding as well as associated properties of neonicotinoid insecticides.

...read moreread less

Book

Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor

出山本, +1 more

TL;DR: The structure and Function of Insect Nicotinic Acetylcholine Receptors Studied with Nicotinoid Insecticide Affinity Probes and the Action of Nicotine in the Mammalian Brain are studied.

...read moreread less