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2021 ELSO Adult and Pediatric Anticoagulation Guidelines.

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TLDR
These guidelines are intended for educational use to build the knowledge of physicians and other health professionals in assessing the conditions and managing the treatment of patients undergoing ECLS / ECMO and describe what are believed to be useful and safe practice for extracorporeal life support (ECLS, ECMO) as mentioned in this paper .
Abstract
These guidelines for adult and pediatric anticoagulation for extracorporeal membrane oxygenation are intended for educational use to build the knowledge of physicians and other health professionals in assessing the conditions and managing the treatment of patients undergoing ECLS / ECMO and describe what are believed to be useful and safe practice for extracorporeal life support (ECLS, ECMO) but these are not necessarily consensus recommendations. The aim of clinical guidelines are to help clinicians to make informed decisions about their patients. However, adherence to a guideline does not guarantee a successful outcome. Ultimately, healthcare professionals must make their own treatment decisions about care on a case-by-case basis, after consultation with their patients, using their clinical judgment, knowledge and expertise. These guidelines do not take the place of physicians' and other health professionals' judgment in diagnosing and treatment of particular patients. These guidelines are not intended to and should not be interpreted as setting a standard of care or be deemed inclusive of all proper methods of care nor exclusive of other methods of care reasonably directed to obtaining the same results. The ultimate judgment must be made by the physician and other health professionals and the patient in light of all the circumstances presented by the individual patient, and the known variability and biological behavior of the clinical condition. These guidelines reflect the data at the time the guidelines were prepared; the results of subsequent studies or other information may cause revisions to the recommendations in these guidelines to be prudent to reflect new data, but ELSO is under no obligation to provide updates. In no event will ELSO be liable for any decision made or action taken in reliance upon the information provided through these guidelines.

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Journal ArticleDOI

Bleeding and thrombotic events in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study

Alexandre Mansour, +147 more
TL;DR: In this paper , the authors describe bleeding and thrombotic events and their risk factors in patients receiving extracorporeal membrane oxygenation (ECMO) for severe coronavirus disease 2019 (COVID-19) and evaluate their impact on in-hospital mortality.
Journal ArticleDOI

Respiratory indications for ECMO: focus on COVID-19

TL;DR: Extracorporeal membrane oxygenation (ECMO) is increasingly being used for patients with severe respiratory failure and has received particular attention during the coronavirus disease 2019 (COVID-19) pandemic as mentioned in this paper .
Journal ArticleDOI

Anticoagulation Strategies during Extracorporeal Membrane Oxygenation: A Narrative Review

TL;DR: A narrative review summarizes the most recent considerations on anticoagulation during ECMO support, with a special focus on antICOagulation monitoring and future directions.
Journal ArticleDOI

Bleeding During Veno-Venous ECMO: Prevention and Treatment

TL;DR: The mechanisms of the underlying pathologies and the route from diagnosis to treatment are described and several acquired bleeding disorders caused by the mechanical pump and the foreign layer of the extracorporeal system contribute to the risk of bleeding.
Journal ArticleDOI

How to manage anticoagulation during extracorporeal membrane oxygenation

TL;DR: In this pragmatic state-of-the-art summary, a review of man-aging in ECMO,Balanc-ing anticoagulation to prevent thrombotic complications against bleeding in these complex critically ill patients during ECMO is an ongoing challenge for clinicians.
References
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Journal ArticleDOI

Extracorporeal Life Support Organization Registry International Report 2016.

TL;DR: Extracorporeal life support use in the support of adults with respiratory and cardiac failure represented the largest growth in the recent time period and underscore the need for skilled ECLS management and appropriately trained ECLs personnel and teams.
Journal ArticleDOI

A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time.

TL;DR: Two hundred and thirty-four patients treated with continuous intravenous infusions of heparin were studied prospectively to seek a relation between the activated partial thromboplastin tim...
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Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety.

TL;DR: The mechanism of action of heparin, its pharmacokinetics, anticoagulant effects, and labo- ratory monitoring will be reviewed and the potential of a new class ofheparins, the low molecular weight heparins (LMWHs) will be discussed and their biophysical, pharmacokinetic, antithrombotic, and hemorrhagic properties will be compared with stan- dard hepar in.
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