Journal ArticleDOI
5-Azacytidine, a new, highly effective cancerostatic
TLDR
Die hohe bakteriostatische und cancerostatischer Wirkung eines neuen Antimetaboliten, 5-Azacytidin, wird beschrieben.Abstract:
Die hohe bakteriostatische und cancerostatische Wirkung eines neuen Antimetaboliten, 5-Azacytidin, wird beschrieben.read more
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Epigenetics in human disease and prospects for epigenetic therapy
TL;DR: Great potential lies in the development of ‘epigenetic therapies’ — several inhibitors of enzymes controlling epigenetic modifications, specifically DNA methyltransferases and histone deacetylases, have shown promising anti-tumorigenic effects for some malignancies.
Journal ArticleDOI
5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.
TL;DR: The current status of the understanding of the mechanism(s) by which 5-azacytosine residues in DNA inhibit DNA methylation is reviewed with an emphasis on the interactions of these residues with bacterial and mammalian DNA (cytosines-C5) methyltransferases.
Journal ArticleDOI
The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
TL;DR: Analysis of molecular interactions and changes in gene copy numbers modulate the activity of DNMTs in diverse gene regulatory functions, including transcriptional silencing, transcriptional activation and post-transcriptional regulation by DNMT2-dependent tRNA methylation enables the DNMT family to function as a versatile toolkit for epigenetic regulation.
Journal ArticleDOI
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
Carlo Stresemann,Frank Lyko +1 more
TL;DR: The pharmacological properties of azanucleosides and their interactions with various cellular pathways are examined and an understanding of the cellular mechanisms mediating transmembrane transport and metabolic activation will be critically important for optimizing patient responses.
Journal Article
Induction of the Polyamine-biosynthetic Enzymes in Mouse Epidermis by Tumor-promoting Agents
TL;DR: The stimulation of both enzyme activities was dependent on the dose of TPA applied and correlated well with the promoting ability of these doses on mouse skin, and enzyme half-lives of 17 and 41 min were obtained for ornithine and S-adenosyl-L-methionine decarboxylase, respectively.
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