Journal ArticleDOI
5-hydroxytryptamine, noradrenaline, and dopamine in brainstem, hypothalamus, and caudate nucleus of controls and of patients committing suicide by coal-gas poisoning
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TLDR
5-H.T. was decreased in suicides but the significance of this finding was offset by the difference in age between the two groups, and there was no significant difference in the concentrations of noradrenaline, dopamine, and 5-hydroxyindoleacetic acid between suicides and controls.About:
This article is published in The Lancet.The article was published on 1969-07-19. It has received 251 citations till now. The article focuses on the topics: Caudate nucleus & Dopamine.read more
Citations
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Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
Journal ArticleDOI
The role of dopamine in the pathophysiology of depression.
TL;DR: Several studies support the hypothesis that major depression is associated with a state of reduced DA transmission, possibly reflected bycompensatory up-regulation of D2receptors, and further research on the contribution of DA to the pathophysiology of depression is justified to improve outcomes for patients with treatment-resistant and nonremitting depression.
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Serotonergic Studies in Patients with Affective and Personality Disorders: Correlates with Suicidal and Impulsive Aggressive Behavior
Coccaro Ef,Larry J. Siever,Howard Klar,Gail Maurer,Karen Cochrane,Thomas B. Cooper,Richard C. Mohs,Kenneth L. Davis +7 more
TL;DR: It is suggested that reduced central serotonergic function is present in a subgroup of patients with major affective and/or personality disorder and is associated with history of suicide attempt in patients with either disorder, but with impulsive aggression in Patients with personality disorder only.
Journal ArticleDOI
Aggression, suicide, and serotonin: relationships to CSF amine metabolites.
Gerald L. Brown,Michael H. Ebert,Peter F. Goyer,David C. Jimerson,William J. Klein,William E. Bunney,Frederick K. Goodwin +6 more
TL;DR: The life history of aggression and history of suicidal behavior in 12 subjects with borderline personality disorders without major affective disorder were examined, and Histories of aggressive behaviors and of suicide attempts were significantly associated with each other.
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Monoamine metabolites in CSF and suicidal behavior.
TL;DR: A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.
References
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Journal ArticleDOI
A sensitive method for spectrophotofluorometric assay of catecholamines.
TL;DR: A method for the assay of catecholamines in tissues is described, which is essentially a combination of the butanol extraction with aluminum adsorption with the advantage of the rapidity of execution and high sensitivity.
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5-Hydroxytryptamine in the Hind-Brain of Depressive Suicides
TL;DR: The knowledge that loss of amines may be associated with depression, and that their replenishment in the brain may induce recovery, immediately leads to the question as to which of the biogenic amines is responsible for the affective changes.
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5-hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases
G. W. Ashcroft,T. B. B. Crawford,D. Eccleston,D.F. Sharman,ElizabethJ. Macdougall,J.B. Stanton,J.K. Binns +6 more
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Noradrenaline, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in hindbrains of suicidal patients.
HenryR. Bourne,WilliamE. Bunney,RobertW. Colburn,JohnM. Davis,J.N. Davis,DavidMurray Shaw,Alec Coppen +6 more
TL;DR: 5-H.A.T., noradrenaline, and 5-hydroxyindoleacetic acid levels were not significantly different, but 5- H.I.A.'s levels was significantly lower in the hindbrains of the suicides.
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Microanalytical procedures for fluoro‐metric assay of brain dopa‐5htp decarboxylase, norepinephrine and serotonin, and a detailed mapping of decarboxylase activity in brain
TL;DR: Modifications of the fluorometric procedures for NE and 5HT estimation whereby they can be assayed in amounts of brain containing as little as 40pmg of NE or 200 pmg of 5HT are described.