Open AccessJournal Article
A better comprehension of “Management of Hyperglycemia in Type 2 Diabetes:A Patient-Centered Approach—Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)”
TLDR
The position statement emphasizes that all patients should accept diabetes education aimed at hyperglycemia control and sets up the target of control of hyper glycemia flexibly according to natural course of disease, pathological condition,accompanied diseases, age, and life expectancy of the patients.Abstract:
" Management of Hyperglycemia in Type 2Diabetes : A Patient-Centered Approach — Position Statement of the American Diabetes Association(ADA) and the European Association for the Study of Diabetes(EASD)" was published in Diabetes Care and Diabetology in April this year.It,first,emphasizes the control of hyperglycemia in the treatment of T2DM;second,sets up the target of control of hyperglycemia flexibly according to natural course of disease,pathological condition,accompanied diseases,age,and life expectancy of the patients;third,once again emphasizes metformin for first-line use;fourth,more specifically discusses the applications,therapeutic effects,and advantages and disadvantages of various insulin preparations,GLP-1,DPP-4inhibitors and GLP-1receptor agonists;fifth,states the individualization treatment;and sixth,underlines that all patients should accept diabetes education aimed at hyperglycemia control.read more
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SGLT-2 inhibitors and cardiovascular risk: Proposed pathways and review of ongoing outcome trials
Silvio E. Inzucchi,Bernard Zinman,Christoph Wanner,Roberto Ferrari,David Fitchett,Stefan Hantel,Rosa-Maria Espadero,Hans-Juergen Woerle,Uli C. Broedl,Odd Erik Johansen +9 more
TL;DR: Those risk factors beyond glucose that can potentially be modulated positively with SGLT-2 inhibitors include blood pressure, weight, visceral adiposity, hyperinsulinaemia, arterial stiffness, albuminuria, circulating uric acid levels and oxidative stress.
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Relationships Between Gastric Emptying, Postprandial Glycemia, and Incretin Hormones
TL;DR: The relevance of postprandial glycemia is further increased by the recognition that it may represent an independent risk factor for adverse cardiovascular outcomes in both diabetic and nondiabetic populations.
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New insulin glargine 300 U/ml compared with glargine 100 U/ml in insulin-naïve people with type 2 diabetes on oral glucose-lowering drugs: a randomized controlled trial (EDITION 3)
Geremia B. Bolli,Matthew C. Riddle,Richard M. Bergenstal,Monika Ziemen,K Sestakauskas,H Goyeau,Philip Home +6 more
TL;DR: To compare the efficacy and safety of new insulin glargine 300 U/ml (Gla‐300) with that ofglargine 100U/ ml (Glo‐100) in insulin‐naïve people with type 2 diabetes using oral glucose‐lowering drugs, a comparison study is conducted.
Journal ArticleDOI
Diabetes Self-management Education and Support in Type 2 Diabetes.
Margaret A. Powers,Joan K. Bardsley,Marjorie Cypress,Paulina Duker,Martha M. Funnell,Amy Hess Fischl,Melinda D. Maryniuk,Linda M. Siminerio,Eva M. Vivian +8 more
TL;DR: From International Diabetes Center at Park Nicollet, Minneapolis, Minnesota (Dr Powers); MedStar Health Research Institute and MedStar Nursing, Hyattsville, Maryland (Ms Bardsley); ABQ Health Partners, Albuquerque, New Mexico (Dr Cypress); LifeScan, a Johnson & Johnson Diabetes Solutions Company, Dubai, United Arab Emirates (Ms Duker).
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HARMONY 3: 104-week randomized, double-blind, placebo- and active-controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin.
Bo Ahrén,Susan L. Johnson,Murray Stewart,Deborah T. Cirkel,Fred Yang,Caroline R Perry,Mark N. Feinglos +6 more
TL;DR: Adding to metformin, albiglutide was well tolerated; produced superior reductions in HbA1c and FPG at week 104 compared with placebo, sitagliptin, and glimepiride; and resulted in weight loss compared with glimePiride.
References
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Journal ArticleDOI
Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society
Elizabeth R. Seaquist,John E. Anderson,Belinda P. Childs,Philip E. Cryer,Samuel Dagogo-Jack,Lisa Fish,Simon Heller,Henry Rodriguez,James L. Rosenzweig,Robert A. Vigersky +9 more
TL;DR: The evidence about the impact of hypoglycemia on patients with diabetes that has become available since the past reviews by the American Diabetes Association and The Endocrine Society is reviewed to provide guidance about how this new information should be incorporated into clinical practice.
Journal ArticleDOI
Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
Kaj Stenlöf,W. T. Cefalu,W. T. Cefalu,Kyoung-Ah Kim,Maria Alba,Keith Usiskin,Cindy Tong,William Canovatchel,Gary Meininger +8 more
TL;DR: The efficacy and safety of canagliflozin were evaluated in subjects with T2DM inadequately controlled with diet and exercise.
Journal ArticleDOI
Diabetes Self-management Education and Support in Type 2 Diabetes: A Joint Position Statement of the American Diabetes Association, the American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics
Margaret A. Powers,Joan K. Bardsley,Marjorie Cypress,Paulina Duker,Martha M. Funnell,Amy Hess Fischl,Melinda D. Maryniuk,Linda Siminerio,Eva M. Vivian +8 more
TL;DR: It is important for health care providers and their practice settings to have the resources and a systematic referral process to ensure that patients with type 2 diabetes receive both DSME and DSMS in a consistent manner.
Journal ArticleDOI
Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
J-F Yale,George L. Bakris,Bertrand Cariou,Dennis K. Yue,Elias David-Neto,Liwen Xi,K. Figueroa,Ewa Wajs,Keith Usiskin,Gary Meininger +9 more
TL;DR: This study evaluated the efficacy and safety of canagliflozin in subjects with T2DM and stage 3 chronic kidney disease.
Journal ArticleDOI
SGLT-2 inhibitors and cardiovascular risk: Proposed pathways and review of ongoing outcome trials
Silvio E. Inzucchi,Bernard Zinman,Christoph Wanner,Roberto Ferrari,David Fitchett,Stefan Hantel,Rosa-Maria Espadero,Hans-Juergen Woerle,Uli C. Broedl,Odd Erik Johansen +9 more
TL;DR: Those risk factors beyond glucose that can potentially be modulated positively with SGLT-2 inhibitors include blood pressure, weight, visceral adiposity, hyperinsulinaemia, arterial stiffness, albuminuria, circulating uric acid levels and oxidative stress.