Journal ArticleDOI
A comparison between wheat germ agglutinin-and choleragenoid-horseradish peroxidase as anterogradely transported markers in central branches of primary sensory neurones in the rat with some observations in the cat.
Brita Robertson,Gunnar Grant +1 more
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It is shown that wheat germ agglutinin-and choleragenoid-horseradish peroxidase give rise to markedly different labelling patterns, with different concentrations of labelled primary afferents in the marginal zone and substantia gelatinosa and less pronounced in the deep parts of the dorsal horn.About:
This article is published in Neuroscience.The article was published on 1985-03-01. It has received 251 citations till now. The article focuses on the topics: Wheat germ agglutinin & Horseradish peroxidase.read more
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Peripheral nerve injury triggers central sprouting of myelinated afferents
TL;DR: It is shown that after peripheral nerve injury the central terminals of axotomized myelinated afferents, including the large Aβ fibres, sprout into lamina II, a structural reorganization in the adult central nervous system that may contribute to the development of the pain mediated by A-fibres that can follow nerve lesions in humans.
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Mechanism of intranasal drug delivery directly to the brain.
TL;DR: The intranasal route can transport drugs directly to the brain from the nasal cavity along the olfactory and trigeminal nerves, and is an exciting area for research as therapeutics come to market.
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Afferent projections to the rat locus coeruleus demonstrated by retrograde and anterograde tracing with cholera-toxin B subunit and Phaseolus vulgaris leucoagglutinin
TL;DR: The aim of this study was to examine the afferents to the rat locus coeruleus by means of retrograde and anterograde tracing experiments using cholera-toxin B subunit and phaseolus leucoagglutinin to indicate that the area surrounding the locus coercedus is divided into individual nuclei with distinctAfferents.
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Central distribution of trigeminal and upper cervical primary afferents in the rat studied by anterograde transport of horseradish peroxidase conjugated to wheat germ agglutinin.
Kristian Pfaller,Jan Arvidsson +1 more
TL;DR: Comparisons of the central projection fields of trigeminal and upper cervical primary afferents indicated a somatotopic organization but with a certain degree of overlap.
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Reorganization of central terminals of myelinated primary afferents in the rat dorsal horn following peripheral axotomy
Clifford J. Woolf,Peter Shortland,M.L. Reynolds,J. Ridings,Timothy P. Doubell,Richard E. Coggeshall +5 more
TL;DR: It is shown that the spread of B‐HRP‐labelled axons into lamina II is detectable at 1 week, maximal by 2 weeks and persists for over 6 months postlesion, which implies that A‐fiber terminal reorganization is a prominent and long‐lasting but not permanent feature of peripheral axotomy.
References
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Neurological Anatomy in Relation to Clinical Medicine
TL;DR: Unique among neuroanatomical texts ... this is no dry compilation of facts but an attention-rivetting discussion of neurological organization.
Journal ArticleDOI
Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers.
Alan R. Light,Edward R. Perl +1 more
TL;DR: Results suggest that there is a highly specialized central projection of primary afferent endings which is related to sensory function and not to fiber diameter, and which receives direct input from cutaneous receptors transmitting activity initiated by innocuous stimulation.
Journal ArticleDOI
Wheat Germ Agglutinin MOLECULAR CHARACTERISTICS AND SPECIFICITY FOR SUGAR BINDING
Yoshiho Nagata,Max M. Burger +1 more
TL;DR: Crystalline wheat germ agglutinin was prepared from unprocessed wheat germ by a new purification procedure and its purity and some of its molecular characteristics were examined by a number of criteria.
Journal ArticleDOI
Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers.
Alan R. Light,Edward R. Perl +1 more
TL;DR: Primary afferent fibers in the lumbar, sacral, and caudal spinal segments of several mammals (rat, cat, monkey) were stained by applying horseradish peroxidase to the proximal part of cut dorsal rootlets and reacting the tissue histochemically after several hours of survival.
Related Papers (5)
The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord.
John E. Swett,Clifford J. Woolf +1 more