Journal ArticleDOI
A laboratory evaluation of immune complexes in patients on inhalant immunotherapy.
Mark R. Stein,Mark R. Stein,George L. Brown,George L. Brown,J.E. Lima,J.E. Lima,Harold S. Nelson,Harold S. Nelson,Ronald I. Carr,Ronald I. Carr +9 more
TLDR
It is suggested that maintenance immunotherapy does not result in an increase of circulating immune complexes and patients receiving maintenance inhalant immunotherapy have no statistically significant differences in incidence of Clq binding immune complexes.Abstract:
Patients with allergic rhinitis receiving maintenance inhalant immunotherapy and two control groups were studied for evidence of circulating immune complexes. The first control group contained patients with allergic rhinitis who had never received immunotherapy. The second control group contained normal volunteers. Patients in the treatment group had no proteinuria. When compared with the control group, the treatment group had no statistically significant differences in incidence of Clq binding immune complexes, cryoglobulinemia, rheumatoid factor, or complement depletion. This initial study suggests that maintenance immunotherapy does not result in an increase of circulating immune complexes.read more
Citations
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Book ChapterDOI
The Biology and Detection of Immune Complexes
TL;DR: This chapter describes the interaction of immune complexes (ICs) with complement and with the cells of the immune system, thereby making it possible to identify the antigens involved in immune processes of a great many diseases, including those of unknown etiology.
Journal ArticleDOI
Systemic reactions and fatalities associated with allergen immunotherapy.
TL;DR: It is essential that strict attention be paid to the risk factors for systemic reactions, and that techniques and management be initiated both before and after skin testing or IT to minimize these risks.
Journal ArticleDOI
Immunotherapy with allergens.
TL;DR: The nasal challenge model has provided a means of investigating the effects of immunotherapy at both the clinical and cellular levels and induced clinical symptoms of allergic rhinitis that correlate with the appearance of various inflammatory mediators in the nasal secretions.
Journal ArticleDOI
Clinical and immunologic aspects of allergen-specific immunotherapy in patients with seasonal allergic rhinitis and/or allergic asthma
TL;DR: The clinical efficacy of specific allergen immunotherapy as an adjunct to the management of patients with seasonal allergic rhinitis and/or extrinsic asthma, as well as in the primary management of Patients with venom hypersensitivity, is well documented.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal Article
Detection of immune complexes in unheated sera by modified 125I-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus.
TL;DR: The modified 125I-Clq binding test was applied to the clinical investigation of 44 patients with systemic lupus erythematosus; and increased Clq binding activity (Clq-BA) was observed in 91% of the samples.
Journal ArticleDOI