Journal ArticleDOI
A method for quantitative determination of flow induced human platelet adhesion and aggregation
TLDR
The results obtained demonstrate the usefulness of the proposed method for quantifying platelet reactivity as reflected by type and degree of flow induced platelet deposition, which provides a basis for correlating the in vitro findings with the disease state.About:
This article is published in Thrombosis Research.The article was published on 1992-08-15. It has received 16 citations till now. The article focuses on the topics: Platelet.read more
Citations
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Journal ArticleDOI
Fluid Mechanics of the Stagnation Point Flow Chamber and Its Platelet Deposition
TL;DR: This flow model applies platelet-rich plasma (PRP) as fluid and the concept of the boundary layer is introduced, which permits assessment of the platelet flow along the wall, indicating that platelets are deposited at a defined shear rate.
Journal ArticleDOI
Flow-based assays for global assessment of hemostasis. Part 2: current methods and considerations for the future.
Jaap Jan Zwaginga,K. S. Sakariassen,Gerard B. Nash,Michael R. King,Johan W. M. Heemskerk,M. Frojmovic,Marc Hoylaerts +6 more
TL;DR: This research presents a novel probabilistic approach called “cell reprograming” that allows for real-time measurement of the response of the immune system to a single substance.
Journal ArticleDOI
Platelet deposition in stagnation point flow: an analytical and computational simulation.
Tim David,S. Thomas,P.G. Walker +2 more
TL;DR: If the wall reaction rate is chosen to be dependent on the wall shear stress then the analysis shows that the maximum platelet flux occurs downstream of the stagnation point, providing a more realistic model of experimental evidence.
Journal ArticleDOI
Increased platelet and coagulatory activity indicate ongoing thrombogenesis in peripheral arterial disease
Cornelia Reininger,Johann Graf,Armin J. Reininger,Michael Spannagl,Bernd Steckmeier,Leonhard Schweiberer +5 more
TL;DR: In this paper, the authors investigated platelet and coagulatory activity in patients with peripheral arterial disease and sought to find the best disease indicator by using stochastic point flow adhesion-aggregometry (SPAA) and agonist-induced aggregometry (Born method).
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Platelet adhesion to collagen type I, collagen type IV, von Willebrand factor, fibronectin, laminin and fibrinogen: rapid kinetics under shear.
TL;DR: Human platelets adhered specifically, rapidly (within seconds) and efficiently to several proteins under flow conditions and the kinetics of adhesion depended on the protein serving as substrate as well as on shear rate.
References
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Journal ArticleDOI
Aggregation of blood platelets by adenosine diphosphate and its reversal.
Journal ArticleDOI
Thrombosis and Acute Coronary-Artery Lesions in Sudden Cardiac Ischemic Death
Michael J. Davies,Anthony Thomas +1 more
TL;DR: The pathologic process in sudden ischemic death involves a rapidly evolving coronary-artery lesion in which plaque fissuring and resultant thrombus formation are present, and these findings have implications for the prevention of sudden cardiac death by antithrombotic therapy.
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The role of blood flow in platelet adhesion, fibrin deposition, and formation of mural thrombi
TL;DR: Experimental data indicate that platelet adhesion and aggregation play a predominant role only at high arterial, blood flow velocities and function independent of coagulation, and fibrin deposition at the subendothelial surface appears to require stagnant blood.
Journal ArticleDOI
Response of cultured endothelial cells to steady flow.
TL;DR: Although cell shape (form) changed in response to shear stress, cell area remained unaffected by exposure to flow.
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Aggregation of human platelets in an annular vortex distal to a tubular expansion
T. Karino,Harry L. Goldsmith +1 more
TL;DR: It is demonstrated for the first time that within a given range of shear stress in a vortex, platelets can aggregate without the addition of any agents.