Patent
A method for reversing the immunosuppressive effects of the Melanoma Inhibitory Activity "MIA"
Karl-Hermann Schlingensiepen,Reimar Schlingensiepen,Rainer Apfel,Wolfgang Brysch,Piotr Jachimczak,Ulrich Bogdahn +5 more
TLDR
A method for stimulating immune cells and/or the immune system, and reducing invasion and metastasis of tumor cells by inhibiting expression and functional activity of 'Melanoma Inhibitory Activity' MIA was proposed in this article.Abstract:
A method for stimulating immune cells and/or the immune system, and/or reducing invasion and/or metastasis of tumor cells by inhibiting expression and/or functional activity of 'Melanoma Inhibitory Activity' MIA.read more
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Patent
Method for selective oligonucleotide modification
Andreas Mitsch,Karl-Hermann Schlingensiepen,Bernd Betzler,Frank Jaschinski,Anneliese Schneider +4 more
TL;DR: In this article, a method for producing a modified oligonucleotide, wherein at least one polymer, preferably polyalkylene oxide, and/or a compound is covalently bound to the 5´-and 3´-end of the oligonotide via native ligation, with the proviso that the polymer and the compound is not a protein or peptide, was presented.
Patent
Antisense oligonucleotide to inhibit melanoma inhibitory activity mia.
TL;DR: An antisense oligonucleotide selected from the group of - the sequence 5′- TTG CAT AAA CCC AAG GAG - 3′ and modifications thereof is defined in this paper.
Patent
Method for inhibiting "melanoma inhibitory activity" mia
Anja-Katrin Bosserhoff,Reinhard Buettner,Mara Szyrach,Guenther Auerbach,Piotr Jachimczak,Karl-Hermann Schlingensiepen +5 more
TL;DR: The present invention is directed to peptides, antibodies and antibody fragments inhibiting activity of "Melanoma Inhibitory Activity" (MIA) as mentioned in this paper, which can be used to prevent melanoma inhibitory activity.
Patent
Compositions and methods for treating pancreatic cancer
TL;DR: In this article, the compositions include antisense oligonucleotides against TGFβ2, wherein the compositions sensitize tumors to anti-tumor therapies and also provided a method for treating cancer using the compositions described herein.
References
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PatentDOI
Characterization of the yeast transcriptome
TL;DR: The integration of positional information with gene expression data allowed for the generation of chromosomal expression maps identifying physical regions of transcriptional activity and identified genes that had not been predicted by sequence information alone.
Patent
Sugar modified oligonucleotides that detect and modulate gene expression.
TL;DR: In this paper, the authors proposed a method for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins, such as HIV, herpes virus, papillomavirus and other infections.
Patent
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
Jeffery J. Wheeler,Marcel B. Bally,Yuan-Peng Zhang,Dorothy L. Reimer,Michael J. Hope,Pieter R. Cullis,Peter Scherrer +6 more
TL;DR: In this paper, the authors describe lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer and can be formed using either detergent dialysis methods or methods which utilize organic solvents.
Journal Article
Melanoma-inhibiting activity, a novel serum marker for progression of malignant melanoma.
Anja-Katrin Bosserhoff,Martin Kaufmann,Brigitte Kaluza,Ilse Bartke,H. Zirngibl,Rüdiger Hein,Wilhelm Stolz,Reinhard Buettner +7 more
TL;DR: Enhanced MIA serum levels are reported in 13 and 23% of patients with stage I and II disease, respectively, and in 100% with stage III or IV disease, revealing the highest sensitivity and specificity among currently available markers.
Patent
Antisense modulation of microtubule-associated protein 4 expression
TL;DR: Antisense compounds, compositions and methods for modulating the expression of microtubule-associated protein 4 are provided in this paper, where the compositions comprise antisense compounds particularly antisense oligonucleotides, targeted to nucleic acids encoding micro-tubule associated protein 4.