Open AccessJournal Article
A new method for the determination of fibrinogen in small samples of plasma.
O D Ratnoff,C Menzie +1 more
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This article is published in Journal of Laboratory and Clinical Medicine.The article was published on 1951-02-01 and is currently open access. It has received 954 citations till now. The article focuses on the topics: Hemostatics & Fibrinogen.read more
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Fibrinogen and risk of cardiovascular disease. The Framingham Study.
TL;DR: The impact of fibrinogen value, considered as a separate variable, on cardiovascular disease was comparable with the major risk factors, such as blood pressure, hematocrit, adiposity, cigarette smoking, and diabetes and was significantly related to these risk factors.
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Measurement of Fibrinopeptide A in Human Blood
Hymie L. Nossel,I. Yudelman,R. E. Canfield,Vincent P. Butler,K. Spanondis,George D. Wilner,G. D. Qureshi +6 more
TL;DR: A radioimmunoassay for FPA is developed and the application of this assay to the measurement of FPA levels in clinical blood samples showed evidence that the immunoreactivity measured in plasma is due to FPA, and that extracts of streptokinasetreated plasma showed a five-fold increase in activity when treated with thrombin and markedly different immunore activity with the two antisera.
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The mechanism of clot dissolution by plasmin
TL;DR: The results indicate that since plasminogen is found both in plasma and also as a constituent of thrombi, clot lysis occurs by a dual mechanism.
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Anticoagulant Action of Heparin
TL;DR: It is proposed that heparin acts to accelerate inhibitor function by binding to antithrombin and inducing an allosteric modification in it, which renders the arginine in its reactive site more accessible to the serine in the active centre of thrombin4.
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Measurement of platelet adhesiveness. a simple in vitro technique demonstrating an abnormality in von willebrand's disease.
TL;DR: In vitro measurements of platelet adhesiveness are consistent with the thesis that the initial aggregation of platelets in hemostasis is not dependent on blood coagulation.