Journal ArticleDOI
A new synthetic route to 2-hydroxynaphthalene-1-carboxylic acid derivatives. An efficient access to the naphthalene moiety of neocarzinostatin chromophore
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TLDR
In this paper, the 1-carbomethoxy-1-alkenyloxybenzocyclobutenes were converted to 2-naphthol by sequential dehydrogenation and deprotection.About:
This article is published in Tetrahedron.The article was published on 1989-01-01. It has received 16 citations till now. The article focuses on the topics: Electrocyclic reaction & Moiety.read more
Citations
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Chemie und Biologie von Endiin-Cytostatica/Antibiotica
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Cyclobutarenes and Related Compounds
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Hypervalent iodine(III)-induced intramolecular cyclization of alpha-(aryl)alkyl-beta-dicarbonyl compounds: a convenient synthesis of benzannulated and spirobenzannulated compounds.
TL;DR: A novel hypervalent iodine(III)-induced direct intramolecular cyclization of α-(aryl)alkyl-β-dicarbonyl compounds has been described and the mechanism has been shown to involve a cation radical intermediate.
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New Intramolecular α-Arylation Strategy of Ketones by the Reaction of Silyl Enol Ethers to Photosensitized Electron Transfer Generated Arene Radical Cations: Construction of Benzannulated and Benzospiroannulated Compounds†
TL;DR: In this article, an efficient intramolecular α-arylation of ketones is achieved by the reaction of silyl enol ethers to photosensitized electron transfer (PET) generated arene radical cations.
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Intramolecular nucleophilic addition of silylenol ether to photosensitized electron transfer (PET) generated arene radical cations: A novel non-reagent based carboannulation reaction:
TL;DR: A new carboannulation strategy by intramolecular addition of silylenol ether to PET generated arene radical cation is reported in this paper, which is based on the same approach as the one described in this paper.
References
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Journal ArticleDOI
The structure of neocarzinostatin chromophore possessing a novel bicyclo-[7,3,0]dodecadiyne system
Kiyoto Edo,Michinao Mizugaki,Yoshio Koide,Haruo Seto,Kazuo Furihata,Noboru Ōtake,Nakao Ishida +6 more
TL;DR: The structure of the chromophore of an antitumor antibiotic neocarzinostatin has been elucidated as a bicycro[7,3,0]dodecadiyne system having naphthalenecarboxylic acid, aminosugar and ethylene carbonate units as mentioned in this paper.
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Studies on the syntheses of heterocyclic compounds—DXLVII
TL;DR: In this article, the thermolysis of 3,4-dihydro-1-(5methoxybenzocyclobutenyl)-β-carboline hydrochloride in bromobenzene gave the decadehydroyohimbane (19), which on reduction with sodium borohydride afforded the hexadehydroyhimbane(20) which had already been converted into (±)-yohimbone (21) and (±) alloy-obligations (21, 22, 23, 24).
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Specific G2 block in HeLa-S3 cells by neocarzinostatin.
TL;DR: The effects of an antibiotic, neocarzinostatin (NCS), on cell division and DNA synthesis in synchronized and random culture of HeLa-S3 cells were examined by using different methods of localizing the site of NCS-induced block of cell progress in their life cycles.
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Naphthalenecarboxylic acid from neocarzinostatin (NCS).
Kiyoto Edo,Shigeru Katamine,Fumio Kitame,Nakao Ishida,Yoshio Koide,Genjiro Kusano,Shigeo Nozoe +6 more
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Synthesis of the naphthalenecarboxylic acid derivative obtained from neocarzinostatin (NCS): A structure revision
TL;DR: The structure of the naphthalenecarboxylic acid derivative obtained from neocarzinostatin (NCS) was revised as methyl 2-hydroxy-7methoxy-5-methyl-1-naphthaleneecar boxylate ( 2a ) by its synthesis as discussed by the authors.