Journal ArticleDOI
A novel total synthesis of (2R,4'R,8'R)-.alpha.-tocopherol (vitamin E). Construction of chiral chromans from an optically active, nonaromatic precursor
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This article is published in Journal of the American Chemical Society.The article was published on 1979-10-01. It has received 59 citations till now. The article focuses on the topics: Total synthesis.read more
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Journal ArticleDOI
Selective targeting of an antioxidant to mitochondria
TL;DR: The targeted derivative of vitamin E protected mitochondrial function from oxidative damage far more effectively than vitamin E itself and suggests a new family of mitochondrially targeted antioxidants, redox-active and pharmacologically active molecules designed to prevent damage or manipulate mitochondrial function.
Book ChapterDOI
Synthesis of vitamin E.
TL;DR: In this article, a broad variety of methods from the repertoire of asymmetric synthesis were applied, that is optical resolution and use of chiral pool starting materials and chiral auxiliaries in stoichiometric as well as catalytic amounts.
Journal ArticleDOI
Reactions of ethyl bromodifluoroacetate in the presence of copper powder
TL;DR: In this paper, the reaction of ethyl bromodifluoroacetate (1 ) in the presence of copper powder as a procedure for the synthesis of compounds containing a CF 2 group was examined.