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A Ternary Complex Reagent for an Asymmetric Reaction of Lithium Ester Enolates with Imines

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This article is published in Journal of the American Chemical Society.The article was published on 1997-02-26. It has received 150 citations till now. The article focuses on the topics: Lithium & Reagent.

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Catalytic enantioselective addition to imines.

TL;DR: Shū Kobayashi was born in 1959 in Tokyo, Japan and studied chemistry at the University of Tokyo and received his Ph.D. in 1988 (Professor T. Mukaiyama), and received the first Springer Award in Organometallic Chemistry in 1997.
Journal ArticleDOI

The proline-catalyzed direct asymmetric three-component Mannich reaction: Scope, optimization, and application to the highly enantioselective synthesis of 1,2-amino alcohols

TL;DR: Proline-catalyzed direct asymmetric three-component Mannich reactions of ketones, aldehydes, and amines are developed and application to the highly enantioselective synthesis of 1,2-amino alcohols is presented.
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