α1-Noradrenergic System Role in Increased Motivation for Cocaine Intake in Rats with Prolonged Access
Reads0
Chats0
TLDR
The data suggest that activation of the alpha 1-noradrenergic system, perhaps in the BNST, is associated with increased motivation for cocaine in rats with extended access.About:
This article is published in European Neuropsychopharmacology.The article was published on 2008-04-01 and is currently open access. It has received 138 citations till now.read more
Citations
More filters
Journal ArticleDOI
A Role for Brain Stress Systems in Addiction
TL;DR: The role of brain stress systems and brain antistress systems in addiction provides novel targets for treatment and prevention of addiction and insights into the organization and function of basic brain emotional circuitry.
Journal ArticleDOI
Neurobiological mechanisms for opponent motivational processes in addiction
George F. Koob,Michel Le Moal +1 more
TL;DR: The combination of loss of reward function and recruitment of brain stress systems provides a powerful neurochemical basis for the long hypothesized opponent motivational processes responsible for the negative reinforcement driving addiction.
Journal ArticleDOI
Addiction as a Stress Surfeit Disorder
George F. Koob,Cara L. Buck,Ami Cohen,Scott Edwards,Paula E. Park,Joel E. Schlosburg,Brooke E. Schmeichel,Leandro F. Vendruscolo,Carrie L. Wade,Timothy W. Whitfield,Olivier George +10 more
TL;DR: Brain stress response systems are hypothesized to be activated by acute excessive drug intake, to be sensitized during repeated withdrawal, to persist into protracted abstinence, and to contribute to the development and persistence of addiction.
Journal ArticleDOI
Neurobiological substrates for the dark side of compulsivity in addiction.
TL;DR: A brain stress response system is hypothesized to be activated by acute excessive drug intake, to be sensitized during repeated withdrawal, to persist into protracted abstinence, and to contribute to the compulsivity of addiction.
Journal ArticleDOI
Brain stress systems in the amygdala and addiction
TL;DR: Compelling evidence argues that these brain stress systems, a heretofore largely neglected component of dependence and addiction, play a key role in engaging the transition to dependence and maintaining dependence once it is initiated.
References
More filters
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine Systems
R Y Moore,Floyd E. Bloom +1 more
TL;DR: The intensity of research on the central catecholaminergic neuron systems has continued unabated since last year's review of the dopaminergic systems, and the richness of important details deserving of inclusion resulted in a richness of information exceeding the pages available.
Journal ArticleDOI
Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy
TL;DR: This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats to examine psychostimulant and opiate reinforcement.
Journal ArticleDOI
Transition from moderate to excessive drug intake : Change in Hedonic set point
Serge H. Ahmed,George F. Koob +1 more
TL;DR: Differential access to cocaine self-administration produced two patterns of drug intake in rats, characterized by an increased early drug loading and an upward shift in the cocaine dose-response function, suggesting an increase in hedonic set point.
Related Papers (5)
Transition from moderate to excessive drug intake : Change in Hedonic set point
Serge H. Ahmed,George F. Koob +1 more