Journal ArticleDOI
Abstract 16612: Efficacy and Safety of Edoxaban for the Management of Elderly Patients With Atrial Fibrillation: Engage AF-TIMI 48
Eri Toda Kato,Robert P. Giugliano,Christian T. Ruff,Sabina A. Murphy,Francesco Nordio,Tetsuya Kimura,James Jin,Hans Lanz,Michele Mercuri,Eugene Braunwald,Elliott M. Antman +10 more
TLDR
The ENGAGE AF-TIMI 48 trial showed that both the high (HD) and low dose (LD) regimens of the once daily oral factor Xa inhibitor edoxaban were non-inferior to well-managed warfarin in preventing stroke and systemic embolic events (SEE) while reducing major bleeding.Abstract:
Background: Elderly patients with atrial fibrillation (AF) treated with anticoagulants are at higher risk of both ischemic and bleeding events compared to younger patients. Intracranial bleeding (ICH) remains one of the most concerning complications of anticoagulation therapy, and risk is strongly related to age. The ENGAGE AF-TIMI 48 trial showed that both the high (HD) and low dose (LD) regimens of the once daily oral factor Xa inhibitor edoxaban were non-inferior to well-managed warfarin (TTR 68.4%) in preventing stroke and systemic embolic events (SEE) while reducing major bleeding. Methods: 21,105 patients were enrolled in ENGAGE-TIMI 48 trial and stratified into pre-specified age categories: Results: Regardless of treatment, the risk of major bleeding and stroke/SEE increased with age (p Conclusion: The efficacy and safety of edoxaban compared to well-managed warfarin are consistent regardless of age in patients with AF. Due to the higher risk of bleeding with increasing age, the absolute benefits of edoxaban are greater in the elderly.read more
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Journal ArticleDOI
Clinical and Safety Outcomes of Oral Antithrombotics for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Network Meta-analysis
Liang Lin,Wee Shiong Lim,Hui Jun Zhou,Ai Leng Khoo,Keng Teng Tan,Aik Phon Chew,David Foo,Jing Jih Chin,Boon Peng Lim +8 more
TL;DR: Clinical and safety outcomes of oral antithrombotics for stroke prevention in AF in younger (65-74 years) and older (≥75 years) elderly are compared and lower rates of SSE and intracranial bleeding were observed with the NOACs compared with warfarin.
Journal ArticleDOI
Direct Oral Anticoagulants for the Prevention of Stroke in Patients with Nonvalvular Atrial Fibrillation: Understanding Differences and Similarities.
Paul P. Dobesh,John Fanikos +1 more
TL;DR: Understanding the subtle differences in the DOACs’ pharmacology, phase 3 study designs, and trial outcomes will allow for a more tailored approach in selecting the right oral anticoagulant for each patient.
Journal ArticleDOI
Real-life Performance of Edoxaban in Elderly Patients With Atrial Fibrillation: a Multicenter Propensity Score-Matched Cohort Study.
Vincenzo Russo,Emilio Attena,Carmine Mazzone,Enrico Melillo,Anna Rago,Gennaro Galasso,Lucia Riegler,Valentina Parisi,Raffaele Rotunno,Gerardo Nigro,Antonio D'Onofrio +10 more
TL;DR: Edoxaban therapy showed a good real-life performance among elderly patients (aged ≥75 years) with AF and a nonsignificant trend in improved adherence was observed between the EDO and VKA groups.
Journal ArticleDOI
Stroke prevention in the elderly atrial fibrillation patient with comorbid conditions: focus on non-vitamin K antagonist oral anticoagulants.
TL;DR: The benefits of non-vitamin K antagonist oral anticoagulants compared with warfarin in the elderly patient population with multiple comorbid conditions are reviewed.
Journal ArticleDOI
North American Thrombosis Forum, AF Action Initiative Consensus Document.
Christian T. Ruff,Jack Ansell,Richard C. Becker,Emelia J. Benjamin,David DeiCicchi,N.A. Mark Estes,Michael D. Ezekowitz,John Fanikos,Jawed Fareed,David A. Garcia,Robert P. Giugliano,Samuel Z. Goldhaber,Christopher B. Granger,Jeff S. Healey,Russell D. Hull,Elaine M. Hylek,Peter Libby,Renato D. Lopes,Kenneth W. Mahaffey,Jessica L. Mega,Gregory Piazza,Arthur A. Sasahara,Farzaneh A. Sorond,Alex C. Spyropoulos,Jeanine M. Walenga,Jeffrey I. Weitz +25 more
TL;DR: The North American Thrombosis Forum Atrial Fibrillation Action Initiative consensus document is a comprehensive yet practical briefing document focusing on stroke and bleeding risk assessment in patients with atrial fibrillation, as well as recommendations regarding anticoagulation options and management.
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