Journal ArticleDOI
Accumulation of porphyrins in cells: influence of hydrophobicity aggregation and protein binding.
TLDR
A strong correlation was found between cell uptake and distribution into octanol, and none of the other factors could be correlated with cell uptake.Abstract:
— For a variety of chemically defined, synthetic and natural porphyrins, the tendency for self aggregation, binding to serum albumin, distribution coefficient betweenoctanol–1 and water and uptake in V79 Chinese hamster cells have been determined. A strong correlation was found between cell uptake and distribution into octanol. None of the other factors could be correlated with cell uptake. These observations might have an impact on the use of porphyrins in photodynamic and boron neutron capture therapy of tumors.read more
Citations
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Journal ArticleDOI
The Chemistry of Neutron Capture Therapy.
Albert H. Soloway,Werner Tjarks,Beverly A. Barnum,Feng-Guang Rong,Rolf F. Barth,I. M. Codogni,J. G. Wilson +6 more
Journal ArticleDOI
State of the art in the delivery of photosensitizers for photodynamic therapy
TL;DR: Different strategies, including polymer-PS conjugation or encapsulation of the drug in colloidal carriers such as oil-dispersions, liposomes and polymeric particles, have been investigated to improve tumour targeting and to minimize the side effects.
Journal ArticleDOI
The Role of Chemistry in the Development of Boron Neutron Capture Therapy of Cancer
TL;DR: The synthesis methods employed for the creation of boron-containing biomolecules and drugs are presented along with representative data concerning their efficacy in tumor localization and the outlook for BNCT is especially bright at this time because of rapid developments in the fields of bioorganometallic chemistry, microbiology, immunology, and nuclear science.
Journal ArticleDOI
Photochemotherapy of cancer: experimental research.
Johan Emelian Moan,Kristian Berg +1 more
TL;DR: A combination of injection of a tumor localizing and photosensitizing dye and local exposure of the tumor region to light constitutes the basis for PCT.
References
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Journal ArticleDOI
A simplified synthesis for meso-tetraphenylporphine
Alan D. Adler,Frederick R. Longo,John D. Finarelli,Joel Goldmacher,Jacques Assour,Leonard Korsakoff +5 more
Journal ArticleDOI
Photosensitizers: therapy and detection of malignant tumors
TL;DR: Perhaps the most significant advance during the past year has been the initiation of Phase III clinical trials of PDT vs standard therapy in treatment of superficial bladder cancer and obstructive endobronchial tumors.
Journal ArticleDOI
The use of a derivative of hematoporphyrin in tumor detection.
Journal Article
Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photodynamic therapy.
Barbara W. Henderson,Stephen M. Waldow,Thomas S. Mang,William R. Potter,Patrick B. Malone,Thomas J. Dougherty +5 more
TL;DR: In both tumors, it was found to be nearly unaffected by PDT if the tumor tissue was excised and explanted immediately following completion of treatment, indicating that the effect of PDT on tumor cells directly was not sufficient to decrease tumor clonogenicity even at doses which led to total macroscopic tumor destruction.