Journal ArticleDOI
Acquisition of Autophagic Vacuoles by Human Erythrocytes Physiological Role of the Spleen
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TLDR
Transfusion studies show that these inclusions can be acquired by normal mature erythrocytes when circulating in an asplenic patient, and suggests that, in the absence of a spleen, autophagic vacuoles may occur in situ in all circulating red cells.About:
This article is published in Blood.The article was published on 1970-11-01. It has received 91 citations till now. The article focuses on the topics: Spleen & Pure red cell aplasia.read more
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Splenic function in sickle-cell diseases.
Marco Antônio Zago,C. Bottura +1 more
TL;DR: The spleen goes through similar successive functional stages in the sickle-cell diseases, namely enlargement in the early years of life, which is followed by hypoactivity and finally atrophy, which seems to be faster in Sickle- cell anaemia than in S/beta(0)-thalassaemia and SC disease.
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Functional hyposplenism in alcoholic liver disease: a toxic effect of alcohol?
A F Muller,P J Toghill +1 more
TL;DR: Splenic function, as assessed by these methods, improves in most patients with abstinence, suggesting that the functional hyposplenism may be a result of a direct toxic effect of alcohol on the spleen.
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Energy-dependent endocytosis in erythrocyte ghosts. IV. Effects of Ca2+, Na+ +K+, and 5'-adenylylimidodiphosphate.
TL;DR: Experimental results reaffirm the conclusion that ATP must be split to engender endocytosis in erythrocyte ghosts under these conditions.
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From sadness to stiffness: the spleen’s progress
Michele Augusto Riva,Federica Ferraina,Andrea Paleari,Marco Vincenzo Lenti,Antonio Di Sabatino +4 more
TL;DR: This paper retrace the fundamental steps of the discovery of the functions of the spleen, and proposes spleen morphology, in particular spleen stiffness, has been proposed as a marker of portal hypertension.
References
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A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron-microscopy
Journal Article
A formaldehyde - glutaraldehyde fixative of high osmolarity for use in electron microscopy
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Staining of Tissue Sections for Electron Microscopy with Heavy Metals
TL;DR: Certain hitherto unobserved details are revealed and some sort of specificity exists, although the factors involved are not yet understood.
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Simple methods for "staining with lead" at high pH in electron microscopy.
TL;DR: It is thought that in these highly alkaline staining solutions lead is present as an hydroxide complex anion (plumbite ion) and that this anion is responsible for the staining, and the methods of preparation are based on this hypothesis.