Journal ArticleDOI
Acquisition of Autophagic Vacuoles by Human Erythrocytes Physiological Role of the Spleen
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TLDR
Transfusion studies show that these inclusions can be acquired by normal mature erythrocytes when circulating in an asplenic patient, and suggests that, in the absence of a spleen, autophagic vacuoles may occur in situ in all circulating red cells.About:
This article is published in Blood.The article was published on 1970-11-01. It has received 91 citations till now. The article focuses on the topics: Spleen & Pure red cell aplasia.read more
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Membrane Remodelling and Vesicle Formation During Ageing of Human Red Blood Cells.
TL;DR: Part of the membrane-skeleton is probably lost together with part of the lipid bilayer in a balanced way, and these findings point to a mechanism for the in vivo release of membrane that is different from that which is known to occur in vitro.
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Partial splenectomy in children under 4 years of age with hemoglobinopathy
TL;DR: partial splenectomy is a safe and effective procedure in children less than 4 years of age with hemoglobinopathies that yields minimal blood loss and retains immune competence and greatly reduces, and in some cases eliminates, the need for blood transfusions.
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Rheology of fetal and maternal blood.
TL;DR: In fetal blood the higher hematocrit and the presence of larger red cells, which cause impaired passage through pores < 5 μm, are counterbalanced by a decreased plasma viscosity, resulting in a whole blood viscosities comparable to that of adults.
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Pediatric systemic lupus erythematosus and neonatal lupus.
TL;DR: Children of mothers with SLE can develop both transient and persistent features of SLE in the neonatal period; the permanent features include congenital complete heart block, endomyocardial fibroelastosis, and other structural cardiac defects.
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Isolation and partial characterization of a high molecular weight red cell membrane protein complex normally removed by the spleen.
Samuel E. Lux,Kathryn M. John +1 more
TL;DR: In this paper, it was shown that reticulocyte membranes contain a high molecular weight aggregate of spectrin and other membrane proteins and that splenic surface remodeling includes the removal of this protein complex as well as membrane lipids.
References
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A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron-microscopy
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A formaldehyde - glutaraldehyde fixative of high osmolarity for use in electron microscopy
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Staining of Tissue Sections for Electron Microscopy with Heavy Metals
TL;DR: Certain hitherto unobserved details are revealed and some sort of specificity exists, although the factors involved are not yet understood.
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Simple methods for "staining with lead" at high pH in electron microscopy.
TL;DR: It is thought that in these highly alkaline staining solutions lead is present as an hydroxide complex anion (plumbite ion) and that this anion is responsible for the staining, and the methods of preparation are based on this hypothesis.