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Autophagic vacuoles in human red cells.
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This article is published in American Journal of Pathology.The article was published on 1966-05-01 and is currently open access. It has received 138 citations till now.read more
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Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Brinda Ravikumar,Sovan Sarkar,Janet E. Davies,Marie Futter,Moisés García-Arencibia,Zeyn W. Green-Thompson,Maria Jimenez-Sanchez,Viktor I. Korolchuk,Maike Lichtenberg,Shouqing Luo,Dunecan Massey,Fiona M. Menzies,Kevin Moreau,Usha Narayanan,Maurizio Renna,Farah H. Siddiqi,Benjamin R. Underwood,Ashley R. Winslow,David C. Rubinsztein +18 more
TL;DR: This review focuses on mammalian autophagy, and an overview of the understanding of its machinery and the signaling cascades that regulate it is given, and the possibility of autophagic upregulation as a therapeutic approach for various conditions is considered.
Journal ArticleDOI
Autophagy in mammalian development and differentiation
Noboru Mizushima,Beth Levine +1 more
TL;DR: The analyses of systemic and tissue-specific knockout models of ATG genes in mice has led to an explosion of knowledge about the functions of autophagy in mammalian development and differentiation.
Journal ArticleDOI
Essential role for Nix in autophagic maturation of erythroid cells
Hector Sandoval,Perumal Thiagarajan,Swapan K. Dasgupta,Armin Schumacher,Josef T. Prchal,Min Chen,Jin Wang +6 more
TL;DR: It is suggested that Nix-dependent loss of ΔΨm is important for targeting the mitochondria into autophagosomes for clearance during erythroid maturation, and interference with this function impairs erythyroidmaturation and results in anaemia.
Journal ArticleDOI
Regulation and role of autophagy in mammalian cells.
Alfred J. Meijer,Patrice Codogno +1 more
TL;DR: The aim of the present review is to give an overview of autophagy and to discuss its regulation by activators and effectors of mTOR and GTPases.
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Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation.
Mondira Kundu,Tullia Lindsten,Chia Ying Yang,Junmin Wu,Fangping Zhao,Ji Zhang,Mary A. Selak,Paul A. Ney,Craig B. Thompson +8 more
TL;DR: It is demonstrated that Ulk1, a serine threonine kinase with homology to yeast atg1p, is a critical regulator of mitochondrial and ribosomal clearance during the final stages of erythroid maturation, and that expression of ulk1 is not essential for induction of macroautophagy in response to nutrient deprivation or for survival of newborn mice.