Journal ArticleDOI
Actions of Vertebrate Sex Hormones
H.G. Williams-Ashman,A. H. Reddi +1 more
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A review of actions of vertebrate sex hormones is presented and influences of sex hormones on structure, metabolism, and functions of reproductive organs are examined.Abstract:
A review of actions of vertebrate sex hormones is presented. The main topics of discussion are: 1) intracellular proteins binding sex hor mones and their metabolites (estrogen uptake by intact normal cells; upt ake of estrogens by mammary gland and by mammary and other tumors; ster eospecific estrogen-binding proteids in responsive tissues; uptake of androgens by animal cells and formation of 5alpha-androstane and other derivatives; 5alpha-dihydrotestosterone-binding proteids; disposition of progesterone in various tissues); 2) testicular feminization syndrome; 3) effects of sex hormones on organ cultures with comments on deoxyribonucleic acid synthesis and cell division in relation to tissue growth; 4) estrogen-mediated pyridine nucleotide transhydrogenase reactions; 5) intracellular "2nd messengers" and sex hormone action (polyamines); 6) physiological actions of 5beta-hydrogenated steroid metabolites and effects of sex hormones on erythropoiesis; 7) influences of sex hormones on structure metabolism and functions of reproductive organs (ribonucleic acid - RNA - and protein synthesis; RNA preparations and genital tissue growth; androgens and cation-activated adenosinetriphosphatase reactions; uptake of glucose and glycogen synthesis; mitochondrial reactions; gonadal hormones and sebaceous glands); <and 8) medieval Chinese protoendocrinology.read more
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Journal ArticleDOI
Female steroid hormones and target cell nuclei.
TL;DR: The data discussed herein demonstrate the great variation in target-tissue response that can occur after administration of steroid hormones, and direct quantitative evidence that sex steroids cause a net increase in the intracellular amounts of specific mRNA molecules in target tissues is provided.
Journal ArticleDOI
Estrogen-Receptor Interaction
TL;DR: It is proposed that receptor transformation is an important step in estrogen action and that a principal role of the hormone is to induce conversion of the receptor protein to a biochemically functional form.
Journal ArticleDOI
Mechanism of action of glucocorticoids.
E. Brad Thompson,Marc E. Lippman +1 more
TL;DR: The mechanism of action of glucocorticoids is reviewed from the standpoint of seeing how far current concepts of the molecular action of steroids go towards explaining the varied physiologic and metabolic effects induced.
Book ChapterDOI
Sex Hormones, Regulatory Behaviors, and Body Weight
TL;DR: An ideal weight-control drug would be one that acts on neural weight-regulating systems to lower body weight set-point without being estrogenic or anti-estrogenic in other hormone-sensitive systems.
Book ChapterDOI
Epithelial-stromal interactions in development of the urogenital tract.
TL;DR: The developmental responses of urogenital organs to sex hormones are not strictly epithelial phenomena, but are interactive processes dependent on both the epithelium and stroma.
References
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Journal Article
Fetal feminization induced by androgen insensitivity in the testicular feminizing syndrome: effect on marriage and maternalism.
Book
Androgens and anabolic agents : chemistry and pharmacology
TL;DR: Reading is a need and a hobby at once and this condition is the on that will make you feel that you must read.