B
Bert W. O'Malley
Researcher at Baylor College of Medicine
Publications - 701
Citations - 53332
Bert W. O'Malley is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Receptor & Progesterone receptor. The author has an hindex of 123, co-authored 676 publications receiving 50988 citations. Previous affiliations of Bert W. O'Malley include Laboratory of Molecular Biology.
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Female steroid hormones and target cell nuclei.
TL;DR: The data discussed herein demonstrate the great variation in target-tissue response that can occur after administration of steroid hormones, and direct quantitative evidence that sex steroids cause a net increase in the intracellular amounts of specific mRNA molecules in target tissues is provided.
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Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation
Sophia Y. Tsai,Jan Carlstedt-Duke,Nancy L. Weigel,Karin Dahlman,Jan-Åke Gustafsson,Ming-Jer Tsai,Bert W. O'Malley +6 more
TL;DR: A steroid hormone responsive element (GRE/PRE), sufficient to confer glucocorticoid and progesterone inducibility when linked to a reporter gene, was used in band-shift assays to examine its molecular interactions with steroid hormone receptors.
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Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases
Rebecca L. Robker,Darryl L. Russell,Lawrence L. Espey,John P. Lydon,Bert W. O'Malley,JoAnne S. Richards +5 more
TL;DR: The identification of two regulated proteases in the ovary, together with their abnormal expression in anovulatory PR knockout mice, suggests that each plays a critical role in follicular rupture and represents a major advance in the understanding of the proteolytic events that control ovulation.
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Molecular cloning of complementary DNA encoding the avian receptor for vitamin D.
TL;DR: This cDNA represents perhaps the rarest mRNA cloned to date in eukaryotes, as well as the first receptor sequence described for an authentic vitamin.
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The steroid receptor superfamily: more excitement predicted for the future.
TL;DR: This superfamily of regulatory molecules was shown to include also the receptors for thyroid hormone (T3) vitamin D3 and retinoic acid and perhaps more surprising was the inclusion of oncogenes such as v-erb A in this family.